Immunohistochemical study of nuclear factor-κB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers

Jenkins, Gareth; Mikhail, Jane; Al-Hamdani, Ali; Brown, Tim; Caplin, Scott; Manson, J M; Bowden, Rory; Toffazal, N; Griffiths, Ann; Parry, J M; Baxter, J. N.

doi:10.1136/jcp.2006.043976

Cited by 36 publications

(21 citation statements)

References 19 publications

(19 reference statements)

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“…In line with NF-kB and COX-2, expression of individual or combinations of proinflammatory cytokines IL-1b, IL-6, IL-8, and TNF-a is significantly increased in Barrett's esophagus and EAC as compared with squamous epithelium (82)(83)(84). IL-1b and IL-8 expression levels also correlate with the stage of EAC (79).…”

Section: Cancer-related Inflammationmentioning

confidence: 67%

Early Diagnostic Biomarkers for Esophageal Adenocarcinoma—The Current State of Play

Shah

Saunders

Barbour

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Esophageal adenocarcinoma (EAC) is one of the two most common types of esophageal cancer with alarming increase in incidence and very poor prognosis. Aiming to detect EAC early, currently high-risk patients are monitored using an endoscopic-biopsy approach. However, this approach is prone to sampling error and interobserver variability. Diagnostic tissue biomarkers related to genomic and cell-cycle abnormalities have shown promising results, although with current technology these tests are difficult to implement in the screening of high-risk patients for early neoplastic changes. Differential miRNA profiles and aberrant protein glycosylation in tissue samples have been reported to improve performance of existing tissue-based diagnostic biomarkers. In contrast to tissue biomarkers, circulating biomarkers are more amenable to population-screening strategies, due to the ease and low cost of testing. Studies have already shown altered circulating glycans and DNA methylation in BE/EAC, whereas disease-associated changes in circulating miRNA remain to be determined. Future research should focus on identification and validation of these circulating biomarkers in large-scale trials to develop in vitro diagnostic tools to screen population at risk for EAC development. Cancer Epidemiol Biomarkers Prev; 22(7); 1185-209. Ó2013 AACR.

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Section: Cancer-related Inflammationmentioning

confidence: 67%

Early Diagnostic Biomarkers for Esophageal Adenocarcinoma—The Current State of Play

Shah

Saunders

Barbour

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…RELA codes for a number of cytokines and growth factors that in turn activate STAT3 resulting in a positive feed-forward loop [71]. NF-kB transcription is up-regulated along the sequence of BE to EAC with concurrent down-regulation of its negative regulator I-kB [77].…”

Section: Transcription Factors Mediate Tumor Promotion and Metastasismentioning

confidence: 99%

The role of inflammation in cancer of the esophagus

O’Sullivan

Phelan

O’Hanlon

et al. 2014

Expert Review of Gastroenterology & Hepatology

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Esophageal adenocarcinoma is the eighth most common malignancy worldwide. The overall prognosis is poor, with 5-year survival ranges of approximately 15-25%, and 30-50% for patients who can be treated with curative intent. There has been a marked increase in incidence of esophageal adenocarcinoma over the last 30 years, with chronic and severe reflux, diet and obesity identified as principal factors fuelling this rise in the West. Esophageal adenocarcinoma is an exemplar model of an inflammation-associated cancer. The key molecular pathways driving tumor development and influencing tumor biology are the subject of considerable research efforts, and is the principal focus of this review. In addition, the diverse range of changes occurring in the local immune response, tissue microenvironment, metabolic profile, intracellular signaling mechanisms and microRNA signatures are discussed, as well as novel targeted therapies.

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“…The transcription factor NF-κB has been found to be upregulated along the sequence from BO to OAC in tissue samples, along with one of its target molecules, IL-8 [35,36]. NF-κB can also be activated by the bile acid deoxycholic acid, a component of refluxate, in oesophageal cells, as well as low pH [37][38][39] IL-8 was upregulated in the proximal segment of BO in patients compared with the distal segment, along with other pro-inflammatory cytokines like IL-1β.…”

Section: Role Of Cytokines Chemokines and Growth Factorsmentioning

confidence: 99%

Barretts to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

Picardo¹,

Maher²,

O'Sullivan³

et al. 2012

Dig Surg

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Cancer-related inflammation is considered the ‘seventh hallmark of cancer’; many studies show that tumours develop and progress within inflammatory diseases. This review focuses on Barrett’s oesophagus, a common condition in which chronic inflammation and resulting alterations in the stroma can lead to carcinogenesis, specifically oesophageal adenocarcinoma. Changes that occur in the tissue microenvironment during development of this disease are discussed. Infiltration of immune cells facilitates tumour development through production of factors that promote carcinogenesis and by enabling tumours to evade the host immune response. Small molecules including cytokines, chemokines and growth factors play key roles in both inflammation and cancer by promoting proliferation, angiogenesis and carcinogenesis and by recruiting immune cells. The extracellular matrix is altered in inflammation, and provides structural support to developing tumours. Hypoxia is a common state in cancers and inflamed tissues which causes DNA damage and induces tumourigenic factors. Finally, tissue vasculature is a vital part of its microenvironment, supplying oxygen, nutrients and growth factors to rapidly dividing cells, and providing a mechanism for metastatic spread. The cells and molecules outlined here represent potential targets for treatment of this cancer, especially in its pre-cancerous, inflammatory stage.

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Immunohistochemical study of nuclear factor-κB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers

Cited by 36 publications

References 19 publications

Early Diagnostic Biomarkers for Esophageal Adenocarcinoma—The Current State of Play

Early Diagnostic Biomarkers for Esophageal Adenocarcinoma—The Current State of Play

The role of inflammation in cancer of the esophagus

Barretts to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

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Immunohistochemical study of nuclear factor-κB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers

Cited by 36 publications

References 19 publications

Early Diagnostic Biomarkers for Esophageal Adenocarcinoma—The Current State of Play

Early Diagnostic Biomarkers for Esophageal Adenocarcinoma—The Current State of Play

The role of inflammation in cancer of the esophagus

Barretts to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

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Barretts to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer