Immunohistochemical study of MMP-2, MMP-9, EGFR and IL-8 in decidual and trophoblastic specimens of recurrent pregnancy loss cases

Karachrysafi, Sofia; Georgiou, Polyxeni; Kavvadas, Dimitrios; Papafotiou, Foteini; Isaakidou, Sofia; Grammatikakis, Ioannis E.; Papamitsou, Theodora

doi:10.1080/14767058.2023.2218523

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The women were divided into two groups; those who experienced unexplained miscarriage, and those who had electively terminated pregnancies. Using immunohistochemical methods, the study found that MMP-9 levels were significantly higher in cases of recurrent pregnancy loss in both trophoblastic and decidual specimens (P < 0.001) (22).…”

Section: Discussionmentioning

confidence: 94%

The association of matrix metalloproteinase-9 and fetal fibronectin in the first trimester threatened miscarriage

Maki,

Ali,

Rawi

2024

Immunopathol Persa

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Introduction: Vaginal bleeding during the first trimester of pregnancy, accompanied by a positive fetal heart rate and a closed cervix, is medically referred to as a threatened miscarriage. This condition is considered the most common complication within the first 12 weeks of pregnancy. It is important to note that, this condition is a potential indication of danger to the fetus, and therefore; requires immediate medical attention and monitoring. Objectives: To evaluate the association of putative biomarkers matrix metalloproteinase-9 (MMP-9) and fetal fibronectin (fFN) in threatened miscarriage. Patients and Methods: A case-control study on threatened miscarriage was conducted at Alkarama hospital and Ibn al Balady Hospital in Baghdad. Serum levels of fFN and MMP-9 were analyzed in 91 pregnant women with matching gestational ages, divided into two groups of threatened miscarriage (patient: n=30) and healthy pregnant women (control: n=61). The differences in serum concentration of fFN and MMP-9 between the two groups, as well as their correlation with clinical outcomes, were statistically evaluated. Results: There were variations in serum concentrations of matrix metalloproteinase9 between the threatened miscarriage group (49.34±1.08 pg/mL) and the control group (12.19±4.90 pg/mL). Statistical analysis showed a p-value of 0.009. FFN levels were found to be higher in the threatened miscarriage patient group (467.85±6.22 pg/mL) compared to the control group (230.66±37.44 pg/mL), with a P-value of 0.003. A positive correlation was observed between MMP-9 and fFN (r=0.877, P=0.001). The 95% confidence interval for fFN was (0.9-0.992) and for MMP-9 was (0.78-0.96). Conclusion: Increased levels of MMP-9 and fFN have been associated with a higher risk of fetal demise.

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Section: Discussionmentioning

confidence: 94%

The association of matrix metalloproteinase-9 and fetal fibronectin in the first trimester threatened miscarriage

Maki,

Ali,

Rawi

2024

Immunopathol Persa

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“…IL-8 has been detected in placenta, amnion, the cervix, and the choriodecidua. IL-8 participates in recognizing placenta–fetus alloantigen by immune cells, and they can act as growth factors for the fetus [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Pregnant Women with Multiple Sclerosis: An Overview of Gene Expression and Molecular Interaction Using Bioinformatics Analysis

Marquez-Pedroza,

Hernández-Preciado,

Valdivia-Tangarife

et al. 2024

IJMS

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Multiple sclerosis (MS) is a common disease in young women of reproductive age, characterized by demyelination of the central nervous system (CNS). Understanding how genes related to MS are expressed during pregnancy can provide insights into the potential mechanisms by which pregnancy affects the course of this disease. This review article presents evidence-based studies on these patients’ gene expression patterns. In addition, it constructs interaction networks using bioinformatics tools, such as STRING and KEGG pathways, to understand the molecular role of each of these genes. Bioinformatics research identified 25 genes and 21 signaling pathways, which allows us to understand pregnancy patients’ genetic and biological phenomena and formulate new questions about MS during pregnancy.

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Immunohistochemical study of MMP-2, MMP-9, EGFR and IL-8 in decidual and trophoblastic specimens of recurrent pregnancy loss cases

Cited by 2 publications

References 25 publications

The association of matrix metalloproteinase-9 and fetal fibronectin in the first trimester threatened miscarriage

The association of matrix metalloproteinase-9 and fetal fibronectin in the first trimester threatened miscarriage

Pregnant Women with Multiple Sclerosis: An Overview of Gene Expression and Molecular Interaction Using Bioinformatics Analysis

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