Immunohistochemical study of microvessel density, CD44 (standard form), p53 protein and c‐erbB2 in gallbladder carcinoma

Abstract

Microvessel density and p53 protein expression increase progressively with increasing tumor invasiveness in gallbladder carcinomas. Microvessel density, p53 protein, CD44s, and perhaps c-erbB2 expression may be implicated in gallbladder carcinoma evolution.

K‐ras, p53 mutations, and microsatellite instability (MSI) in gallbladder cancer

“…Our finding that p53 mutations mainly characterize tumors of rather advanced stages is concordant with a recent immunohistochemical study of Greek patients [34] implying that p53 mutation could be considered as a late event in GC evolution. Similarly, in colorectal tumorigenesis, p53 mutations have been described as a relatively late event in the adenoma-carcinoma sequence.…”

p53 immunoexpression in stepwise progression of cutaneous squamous cell carcinoma and correlation with angiogenesis and cellular proliferation

“…Using panendothelial markers, MVD significantly correlates with p53 positivity in prostatic [46], breast [47] and gastrointestinal cancer [48][49][50][51][52]. However such correlation has not been found in gallbladder [53] and hepatocellular carcinoma [54]. Through CD105, no significant association between MVD and p53 has been detected in ovarian [55] and endometrial cancer [56].…”

Adenocarcinoma of the Gallbladder: Risk Factors and Pathogenic Pathways

“…The role of p53 gene alterations in CG is still not clarified (Ajiki et al 1996b;Jonas et al 1997;Kim et al 2001a,b;Quan et al 2001;Koda et al 2003;Wang et al 2006;Ghosh et al 2013, review: Rai et al 2011. Overall, p53 is expressed in CG with a high frequency (Fujii et al 1996;da Rocha et al 2004;Kalekou and Miliaras 2004;Wang et al 2006). There is evidence that p53 expression is more prevalent in the gallbladder with gallstones in patients with CG (Misra et al 2000).…”