Immunohistochemical study of Ki-67, p53 and Notch1 expressions in prostate cancer of different grades

Kudryavtsev, G. Y.; Kudryavtseva, L V; Михалева, Л. М.; Solovieva, N A; Бабиченко, И. И.

doi:10.17116/patol20208205142

Cited by 3 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 Proliferation parameters such as MIB-1 LI have also been proposed to predict the recurrence of meningioma. [22][23][24][25] Ros-Sanjuan et al advocated that total resection was the only significant factor associated with recurrence, 26 and furthermore, Simpson proved that the degree of resection grading system he proposed was related to tumor recurrence. 27 However, some scholars believe that the Simpson classification cannot be used as a predictive indicator.…”

Section: Treatment and Prognosismentioning

confidence: 99%

Lateral Ventricular Meningiomas: Clinical Features, Radiological Findings and Long-Term Outcomes

Teng

Yan

et al. 2021

CMAR

View full text Add to dashboard Cite

Purpose Lateral ventricle meningioma (LVM) is a rare type of intracranial meningioma, which has been rarely studied. It has different clinical features, imaging features, and long-term results from other locations. This study investigated the epidemiology, clinical characteristics and prognosis of LVM and comprehensively describes its characteristics. Methods This article analyzes the LVMs that were diagnosed pathologically in West China hospital between January 1, 2009 and July 1 2020. Demographic information, imaging characteristics and prognostic factors are discussed. Data analysis was performed using SPSS 23.0 and R version 3.5.3. Results We collected 7202 meningiomas and 195 LVMs (136 females; median age, 46 years; range, 5–81 years) were included in this study. Gross total resection was completed in 189 patients. The OS rate was 93.8%, and the recurrence rate was 5.2%. Multivariate regression analysis showed that sex (P = 0.01) and tumor size (P = 0.018) were related to WHO grade. Postoperative KPS (P = 0.003) was associated with OS. WHO grade (P = 0.025), extent of tumor resection (P < 0.001), and hospital day (P=0.028) were associated with recurrence. Conclusion LVMs require long-term follow-up, individualized treatment, and follow-up strategies to be formulated according to the relevant risk factors.

show abstract

Section: Treatment and Prognosismentioning

confidence: 99%

Lateral Ventricular Meningiomas: Clinical Features, Radiological Findings and Long-Term Outcomes

Teng

Yan

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

Diagnostic Utility of Immunohistochemical Expression of Ki-67, P63 and Amacr in Prostate Intraepithelial Neoplasia

Мelnychuk

2023

Wiad Lek

View full text Add to dashboard Cite

The aim: To determine malignant transformation and progression ability of high grade and low grade prostate intraepithelial neoplasia with the help of immunohistochemical method. Materials and methods: The results of examination of 93 patients with PIN (50 patients with high grade PIN and 43 patients with low grade PIN) were assessed comparatively using immunohistochemical markers. Semiquantitative method was used to evaluate !"-67, #63 and AMACR tissue expression with four grades from „+” to „++++” or from 1 to 4 points: ‘+’ – low reaction, ‘++’ – poor reaction, ‘+++’ – moderate reaction and ‘++++” – intense reaction. Results: There were statistically signi!cant di"erences in immunohistochemical expression rates between HGPIN and LGPIN. Patients with HGPIN had higher Ki-67 and AMACR expression rate and lower p63 expression rate than patients with LGPIN. Intense and moderate Ki-67 expression was detected in HGPIN more often, in 24 % and 11 % respectively. Low and moderate AMACR expression was determined in HGPIN more often, in 28 % and 5 % respectively. Low and not evident p63 expression was observed in HGPIN more often, in 36 % and 8 % respectively. Conclusions: HGPIN has common morphological peculiarities with prostate adenocarcinoma. Immunohistochemical detection of Ki-67, p63 and AMACR is aimed to differentiate among patients with PIN a group of high malignant transformation risk.

show abstract

Cell renewal index in the differential diagnosis of atypical small acinar proliferation and adenocarcinoma of the prostate

Dub

2023

jour

View full text Add to dashboard Cite

Introduction Singling out such diagnostic category as atypical small acinar proliferation of the prostate (ASAP) determines the necessity of forming additional approaches to differential morphological diagnosis in order to determine adenocarcinoma in time. Cell renewal index (CRI) is actively used to study proliferation and apoptosis in the epithelial cells of hormone-dependent glands, but in prostate pathology this criterion has not been studied.The aim of the study was to characterize the cell renewal index in atypical small acinar proliferation and prostate adenocarcinoma of different degrees of differentiation in order to optimize differential diagnosis.Materials and methods We studied 720 prostate biopsy specimens from 60 patients: Group 1 — 15 patients with ASAP; Group 2 − 15 with adenocarcinoma of high-grade of differentiation; Group 3 − 15 with moderately differentiated adenocarcinoma; Group 4 − 15 with low differentiated adenocarcinoma. We used immunohistochemical method (Ki-67, CPP32) and non-parametric statistical methods of investigation.Results The CRI in ASAP was comparable to that in highly differentiated adenocarcinoma (p=0.5). In moderately differentiated adenocarcinoma the CRI was significantly higher than in ASAP and highly differentiated adenocarcinoma (p=0.004). The greatest increase in CRI was noted in the low-differentiated adenocarcinoma group, which was higher and significantly different from the ASAP (p=0.000), highly differentiated carcinoma (p=0.003) and moderately differentiated prostatic carcinoma (p=0.000) groups.Discussion On the basis of statistical analysis the present study helped to reveal the identity of CRI parameters in ASAP and highly differentiated adenocarcinoma of the prostat, which allows to add a number of morphological criteria for transferring patients from the group of undetermined diagnosis of ASAP to the group of adenocarcinoma. There is a need for further investigation of CRI with multiparametric analysis including investigation of the expression levels of hormones involved in the regulation of cell renewal in the prostate and growth factors associated with them.Conclusion The study allowed to reveal the identity of the CRI in ASAP and highly differentiated adenocarcinoma of the prostate, which can supplement a number of morphological criteria for transferring patients from the group of undeterminate diagnosis of ASAP to the group of adenocarcinoma.

show abstract

Immunohistochemical study of Ki-67, p53 and Notch1 expressions in prostate cancer of different grades

Cited by 3 publications

References 27 publications

Lateral Ventricular Meningiomas: Clinical Features, Radiological Findings and Long-Term Outcomes

Lateral Ventricular Meningiomas: Clinical Features, Radiological Findings and Long-Term Outcomes

Diagnostic Utility of Immunohistochemical Expression of Ki-67, P63 and Amacr in Prostate Intraepithelial Neoplasia

Cell renewal index in the differential diagnosis of atypical small acinar proliferation and adenocarcinoma of the prostate

Contact Info

Product

Resources

About