Immunohistochemical study of fibroblast growth factor-2 (FGF-2) and fibroblast growth factor receptor (FGF-R) in experimental squamous cell carcinoma of rat submandibular gland

Sumitomo, Shinichiro; Okamoto, Yoshihisa; Mizutani, G.; Kudeken, Wataru; Mori, Masahiko; Takai, Yoshiaki

doi:10.1016/s1368-8375(98)00067-0

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Myoken et al found higher expression of FGF‐2 and FGFR‐1 in 12 malignant SGTs and suggested that these factors might contribute to tumor progression in an autocrine manner. Similar results were found by Sumitomo et al, with co‐expression of these proteins in cells suffering malignant transformation during experimental SCC in rat submandibular glands. Furthermore, serum and saliva levels of FGF‐2 and FGFR‐1 were elevated in 43 patients with either benign or malignant SGT, and Ach et al found FGFR1 gene aberrations in 266 carcinomas of salivary glands by fluorescence in situ hybridization (FISH) analysis (Table ).…”

Section: Fgf‐2/fgfr‐1 Expression In Normal and Neoplastic Tissues Of supporting

confidence: 89%

Expression of FGF‐2/FGFR‐1 in normal mucosa, salivary gland, preneoplastic, and neoplastic lesions of the oral cavity

Mariz

Soares

Morais

et al. 2018

J Oral Pathology Medicine

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Fibroblast growth factor 2 (FGF-2) is a multifunctional cytokine expressed in several tissues and involved in a wide variety of biologic activities, with one low molecular weight (LMW) protein present in the cytosol, which is secreted, acting via its receptors (FGFRs), and four high molecular weight (HMW) proteins located in the nucleus. Fibroblast growth factor receptor (FGFR) family has four (FGFR1-4) transmembrane tyrosine kinase receptors expressed on several cell types, and FGFR-1 has been indicated as a potential molecular target in several types of cancer, including oral squamous cell carcinoma (OSCC). The FGF-2/FGFR-1 expression has been studied in the oral cavity, and it was associated with the wound repair process, the development of benign and malignant salivary gland tumors, besides being related to oral potentially malignant disorders (OPMDs) and OSCC. Hence, we critically review the currently available data on FGF-2/FGFR-1 expression in the normal mucosa and lesions of the oral cavity.

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Section: Fgf‐2/fgfr‐1 Expression In Normal and Neoplastic Tissues Of supporting

confidence: 89%

Expression of FGF‐2/FGFR‐1 in normal mucosa, salivary gland, preneoplastic, and neoplastic lesions of the oral cavity

Mariz

Soares

Morais

et al. 2018

J Oral Pathology Medicine

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“…In addition many other tumor types express FGF-2/FGF-R at high levels (Berger et al, 1999;Sumitomo et al, 1999;Tamiya et al, 1998;Ueki et al, 1995;Xerri et al, 1996;Yoshimura et al, 1998).…”

mentioning

confidence: 99%

“…The selective effects of FGF-2 and VEGF on endothelial cells have been described to regulate cell proliferation (Goto et al, 1993), integrin expression and function (Senger et al, 1996), metalloproteinase activators (Mandriota and Pepper, 1997;Pepper et al, 1991Pepper et al, , 1998, matrix-dependent adhesion and migration (Senger et al, 1996), cell permeability and cell-cell junction alterations (Dellian et al, 1996;Hippenstiel et al, 1998), and morphogenic differentiation and vascular lumen formation (Pepper et al, 1992). FGF-2 is a growth factor that activates a proliferative response in many cell types in addition to endothelial cells, including stromal and tissue fibroblasts (Berger et al, 1999;Ittman and Mansukhani, 1997;Sumitomo et al, 1999;Yoshimura et al, 1998). The role of FGF-2 in promoting a stromal response in relation to tumor angiogenesis has not been addressed to date.…”

mentioning

confidence: 99%

Fibroblast Growth Factor 2 Activation of Stromal Cell Vascular Endothelial Growth Factor Expression and Angiogenesis

Claffey

Abrams²,

Shih

et al. 2001

Laboratory Investigation

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“…This suggests that aFGF stimulates tyrosine kinase activity of FGFR, followed by the transduction of growth signals. Together, it is likely that the growth of the mouse submandibular gland carcinoma cells is regulated by aFGF in autocrine and paracrine manners, as described in other systems (20,22,39,51).…”

Section: Discussionmentioning

confidence: 93%

Enhancing effects of fibroblast growth factor on the proliferation of salivary gland carcinoma cells and salivary gland carcinogenesis

Yura

Yoshioka

Yamamoto

et al. 2001

J Oral Pathology Medicine

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The proliferation of mouse submandibular gland carcinoma YT-12 cells was stimulated by endothelial cell growth factor (ECGF)/bovine brain-derived acidic fibroblast growth factor (aFGF) and recombinant human aFGF. To determine whether aFGF was capable of modifying salivary gland carcinogenesis, the effect of brain-derived aFGF was examined in vivo. Mice in Groups 1 and 2 were injected with 9,10-dimethyl-1,2-benzanthracene (DMBA) into the left submandibular gland, and then Group 1 mice received bovine brain-derived aFGF and Group 2 mice received vehicle subcutaneously for 10 weeks. Group 3 and 4 mice received either bovine brain-derived aFGF or vehicle only. Sixteen weeks after the start of the experiment, the incidence of submandibular gland carcinomas in Group 1 was significantly greater than that in Group 2. Immunohistochemical study indicated that ducts in the normal submandibular glands and carcinomas showed positive staining with anti-aFGF antibody. Immunoblot and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed the expression of aFGF in these tissues. FGF receptor (FGFR)-1 and FGFR-4 were detectable in the mouse submandibular glands and carcinomas. These findings suggest that bovine brain-derived aFGF stimulates the proliferation of submandibular gland carcinoma cells and promotes mouse submandibular gland carcinogenesis.

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Immunohistochemical study of fibroblast growth factor-2 (FGF-2) and fibroblast growth factor receptor (FGF-R) in experimental squamous cell carcinoma of rat submandibular gland

Cited by 8 publications

References 26 publications

Expression of FGF‐2/FGFR‐1 in normal mucosa, salivary gland, preneoplastic, and neoplastic lesions of the oral cavity

Expression of FGF‐2/FGFR‐1 in normal mucosa, salivary gland, preneoplastic, and neoplastic lesions of the oral cavity

Fibroblast Growth Factor 2 Activation of Stromal Cell Vascular Endothelial Growth Factor Expression and Angiogenesis

Enhancing effects of fibroblast growth factor on the proliferation of salivary gland carcinoma cells and salivary gland carcinogenesis

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