Immunohistochemical Study of Chondrolipoma: Possible Importance of Transforming Growth Factor (TGF) ‐βs, Latent TGF‐ β Binding Protein‐1 (LTBP‐1), and Bone Morphogenetic Protein (BMP) for Chondrogenesis in Lipoma

Abstract

To clarify the pathogenesis of chondrolipoma, we examined the expressions and localizations of TGF-beta1, -beta2, -beta3, BMP, and LTBP-1 in our rare case by immunohistochemical staining, and compared them with the staining patterns seen in normal human tracheal cartilage tissue and osteochondroma (controls). In the present case, there was weak TGF-beta1 expression in both lacuna and spindle cells around the cartilage, intense TGF-beta2 expression in both lacuna and spindle cells, and weak-to-moderate TGF-beta3 expression in the spindle cells. In lacuna cells, LTBP-1 was expressed moderately and BMP intensely. In contrast, the normal cartilage showed weak-to-moderate expressions of TGF-beta2, -beta3, and BMP in the lacuna cells with zero-to-weak TGF-beta2 and zero-to-moderate TGF-beta3 expressions in the spindle cells, while LTBP-1 was negative in both lacuna and spindle cells. Osteochondroma cases showed moderate-to-intense expressions of TGF-beta2, -beta3, and BMP in the lacuna cells, while LTBP-1 was positive in the lacuna cells and negative in the spindle cells. These findings suggest that the pattern of expression of TGF-betas, LTBP-1, and BMP may be important in the pathogenesis of chondrolipoma.

Chondrolipoma of the popliteal fossa and Japanese reports

“…Chondrolipoma is a rare form of benign mesenchymoma containing mature cartilage and adipose tissue 1,2 . A limited number of chondrolipomas have been reported in the English language published work 1,2 and also in Japanese 3–12 . Herein, the author describes an early chondrolipoma of the popliteal fossa with review of the Japanese published work.…”

Chondrolipoma in the Pelvic Cavity: a Case Report

“…The second is that the cartilage may originate from multipotential cells in the mesenchymoma. A previous immunohistochemical study supported the explanation that the pattern of expression for growth factor-β, latent transforming growth factor-β binding protein-1 transforming, and bone morphogenetic protein might play an important role in the transformation of multipotential cells into the chondrolipoma (11). Considering the proximity of the identified chondrolipoma to the iliac bone of our case study, we agree with the first explanation of chondroid-osseous metaplasia, which states that the mass may be a result of a micro-trauma.…”

Giant chondrolipoma of the tongue in a 14-year-old child with mandibular hypertrophy. Isolated lesion or regional overgrowth syndrome

“…Mechanical trauma and frequent contact with periosteum, tendons or joint capsules might increase the possibility of this metaplasia 3 . Immunohistochemical study concluded that chondrogenesis in lipoma may be enhanced by overproduction of transforming growth factor (TGF bs) and bone morphogenetic protein (BMP) 7 . Chondrolipoma is mainly encountered in large-sized, long-standing lipomas and most of these tumours are solitary and circumscribed.…”