Immunohistochemical studies of the neurochemical markers, CGRP, enkephalin, galanin, γ-MSH, NPY, PHI, proctolin, PTH, somatostatin, SP, VIP, tyrosine hydroxylase and neurofilament in nerves and cells of the human attached gingiva

Luthman, Johan; Johansson, Ӧlle; Ahlström, Ulf; Kvint, Sonja

doi:10.1016/0003-9969(88)90039-8

Cited by 55 publications

(35 citation statements)

References 41 publications

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“…Studies in guinea pig have shown that most neurons expressing SP are nociceptors whereas those expressing CGRP may belong to either nociceptive or non‐nociceptive classes of afferents (Lawson et al ., 1997, 2002). SP‐ and CGRP‐containing sensory nerve terminals have been located in the gingivae and periodontium of many species including rat and humans (Silverman & Kruger, 1987; Luthman et al ., 1988; Kvinnsland & Kvinnsland, 1990; Norevall et al ., 1995) and SP and CGRP show increased expression in local nerve terminals innervating inflamed periodontium (Bartold et al ., 1994; Kimberly & Byers, 1988).…”

Section: Introductionmentioning

confidence: 99%

Sensory neuropeptide mRNA up‐regulation is bilateral in periodontitis in the rat: a possible neurogenic component to symmetrical periodontal disease

El-Aleem

Morales-Aza

Donaldson

2004

Eur J of Neuroscience

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Periodontal disease is a common multifactorial chronic inflammatory disease in humans. In inflammatory conditions that are known to be associated with changes in nociception, such as arthritis, the neuronal expression of the proinflammatory neuropeptides, substance P and calcitonin gene-related peptide is altered. In this study the expression of these neuropeptides' mRNAs has been studied in an inflammatory model that shows no behavioural evidence of altered nociception. Periodontitis was induced in male rats by intragingival injection of lipopolysaccharide adjacent to the second right mandibular molar. The animals were killed at various times after lipopolysaccharide injection and right and left trigeminal ganglia and brain were processed for in situ hybridization for beta-preprotachykinin and alpha-calcitonin gene-related peptide mRNAs. Expression of both neuropeptide mRNAs was significantly increased only in small neurons in the mandibular division of the trigeminal ganglion ipsilateral to the LPS injection from 3 to 10 days postinjection. Neuropeptide mRNA expression was also significantly increased in the contralateral trigeminal ganglion at day 10. No significant changes in neuropeptide mRNA levels were seen in the maxillary and ophthalmic divisions of the trigeminal ganglia or in the trigeminal mesencephalic nucleus. The up-regulation of substance P and CGRP mRNAs in periodontal disease suggests that this is associated with the inflammatory process rather than nociception, as this disease does not appear to result in altered nociception in either rats or humans. The contralateral alteration in neuropeptide mRNA expression suggests a role for neurogenic mechanisms in the development of periodontal disease.

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Section: Introductionmentioning

confidence: 99%

Sensory neuropeptide mRNA up‐regulation is bilateral in periodontitis in the rat: a possible neurogenic component to symmetrical periodontal disease

El-Aleem

Morales-Aza

Donaldson

2004

Eur J of Neuroscience

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“…Similar to other tissues in the body, the periodontium contains receptors, such as nociceptors and mechanoreceptors, which sense pain, touch, and pressure 19‐21 . In addition to different types of sensory receptors, nerve components are found innervating blood vessels of the periodontium 22,23 …”

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confidence: 99%

Unilateral Severe Chronic Periodontitis Associated With Ipsilateral Surgical Resection of Cranial Nerves V, VI, and VII

Zavarella

Leblebicioğlu

Claman

et al. 2006

Journal of Periodontology

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“…SP causes vasodilation by acting directly on the smooth muscle cells and indirectly by stimulating histamine release from the mast cells. The fibers of periodontal tissues in humans are immunoreactive to this substance and to a number of neuropeptides, including calcitonin gene‐related peptide (CGRP), vasoactive intestinal polypeptide (VIP), and neuropeptide Y (NPY) …”

Section: Introductionmentioning

confidence: 99%

Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review

Ávila

Molon

Gonçalves

et al. 2014

J of Invest & Clin Dent

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The aim of the current review was to investigate the relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain. Substance P is a neuropeptide that is directly related with pain. In periodontal disease, it is expressed during the inflammatory process, and is one of the factors responsible for bone resorption. Studies have shown that Substance P levels are highest in the gingival crevicular fluid from sites with active periodontal disease and bone loss. The persistence of these substances could be sufficient to stimulate neurogenic inflammation in susceptible tissues, and cause pain. The scientific literature shows that Substance P expressed during periodontal disease can be a risk factor for patients with systemic inflammatory pathologies, such as chronic arthritis or rheumatoid arthritis. Additional research is needed to confirm the participation of this substance in the origin of some types of chronic pain.

show abstract

Immunohistochemical studies of the neurochemical markers, CGRP, enkephalin, galanin, γ-MSH, NPY, PHI, proctolin, PTH, somatostatin, SP, VIP, tyrosine hydroxylase and neurofilament in nerves and cells of the human attached gingiva

Cited by 55 publications

References 41 publications

Sensory neuropeptide mRNA up‐regulation is bilateral in periodontitis in the rat: a possible neurogenic component to symmetrical periodontal disease

Sensory neuropeptide mRNA up‐regulation is bilateral in periodontitis in the rat: a possible neurogenic component to symmetrical periodontal disease

Unilateral Severe Chronic Periodontitis Associated With Ipsilateral Surgical Resection of Cranial Nerves V, VI, and VII

Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review

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