Immunohistochemical Profiles of Matrix Metalloproteinases and Vascular Endothelial Growth Factor Overexpression in the Antoni B Area of Vestibular Schwannomas

Xia, Lei; Yang, Shuxu; Wang, Chengde; Yu, Enxing; Zhang, Hengli; Zhang, Ying; Ruan, Linhui; Shi, Liuzhi; Ni, Jinyao; Luo, Jianmin; Cao, Zhikai; Wen, Ming‐Shien

doi:10.1016/j.wneu.2020.07.208

Cited by 11 publications

(19 citation statements)

References 41 publications

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“…The proteolytic activity of MMP-14 was related to the degree of SNHL in VS patients. (39)(40)(41) The expression of ADAM9 was higher in VS and related to functional impairment. (42,43)…”

Section: Proteasesmentioning

confidence: 99%

“…VEGF is one of the most prominent angiogenesis stimulator that can regulate irregular blood vessel sprouting and growth except for simple remodeling of the capillary basement membrane (65), and lead to development of an immuno suppressive tumor microenvironment (66). Compared with normal vestibular nerve, the expression of VEGF, VEGFR-1/Flt and VEGFR-2/Flk as well as the coreceptor NP1 were considerable increased in VS tissues, suggesting at least a part of neoplastic growth was induced via the promotion of angiogenesis (39,64,67). Tissue microarray analysis of 182 sporadic VSs found significantly higher VEGF levels in the groups of recurrent and preoperatively irradiated tumors when compared to primary VS patients (67).…”

Section: Rtksmentioning

confidence: 99%

“…Histologically, VS can be classified into two tissue types, where Antoni type A has a compact structure with interwoven bundles of long bipolar spindle cells and Antoni type B characterized by a loose texture and small, uniform satellite cells. It is known that cystic VS consist of a large mass of Antoni type B area, where the expression of MMP-14 was significantly higher than that in Antoni type A (39). The abundance and proteolytic activity of MMP-14 in VS patients was correlated with the degree of SNHL and surgical outcomes (41).…”

Section: Proteins In Tumor Tissuementioning

confidence: 99%

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Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

et al. 2021

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Vestibular schwannomas (VSs, also known as acoustic neuromas) are relatively rare benign brain tumors stem from the Schwann cells of the eighth cranial nerve. Tumor growth is the paramount factor for neurosurgeons to decide whether to choose aggressive treatment approach or careful follow-up with regular magnetic resonance imaging (MRI), as surgery and radiation can introduce significant trauma and affect neurological function, while tumor enlargement during long-term follow-up will compress the adjacent nerves and tissues, causing progressive hearing loss, tinnitus and vertigo. Recently, with the deepening research of VS biology, some proteins that regulate merlin conformation changes, inflammatory cytokines, miRNAs, tissue proteins and cerebrospinal fluid (CSF) components have been proposed to be closely related to tumor volume increase. In this review, we discuss advances in the study of biomarkers that associated with VS growth, providing a reference for exploring the growth course of VS and determining the optimal treatment strategy for each patient.

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“…The proteolytic activity of MMP-14 was related to the degree of SNHL in VS patients. (39)(40)(41) The expression of ADAM9 was higher in VS and related to functional impairment. (42,43)…”

Section: Proteasesmentioning

confidence: 99%

Section: Rtksmentioning

confidence: 99%

Section: Proteins In Tumor Tissuementioning

confidence: 99%

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Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

et al. 2021

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“…On the other hand, Antoni B cells are characterized by hypocellularity, loose microcystic tissue, and intratumoral microhemorrhage. The cystic component in schwannomas, represented by Antoni B cells, is highly consistent with the degree of cystic degeneration [2] . Cellular architecture is useful in explaining imaging features of cystic-dominant, solid-dominant, mixed-cystic, and solid schwannomas and the accompanying intratumoral hemorrhage or fluid-fluid level.…”

Section: Introductionmentioning

confidence: 66%

Vestibular schwannoma with fluid-fluid levels mimicking aneurysm bone cyst

Tuan

Hung

Khuong

et al. 2023

Radiology Case Reports

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“…Charabi et al 31 reported that an increase in the size of cystic VSs may be caused by an expansion of the cystic component rather than by an actual increase in the number of tumor cells. However, Xia et al 32 recently conducted immunohistochemical studies of cystic and solid VSs and found that VEGF overexpression increased tumor vessel permeability and caused cyst fluid to leak from the fragile neovasculature, which in turn caused cystic expansion and intratumoral hemorrhage. Moreover, VEGF is known to promote tumor vascular permeability 33 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Signal Intensity of Vestibular Schwannoma Between Growing and Nongrowing Tumors

et al. 2021

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Objectives/Hypothesis: To determine the relationship between signal intensity on gadolinium (Gd)-enhanced magnetic resonance images and growth of vestibular schwannomas (VSs).Study Design: Cross-sectional study.Methods: In this cross-sectional study, we retrospectively reviewed the data of 31 patients with VSs who underwent magnetic resonance imaging (MRI). The mean signal intensities within the regions of interest in the tumor, pons, and temporal muscles were measured on Gd-enhanced T1-weighted MRI. Relative intensity ratios were calculated as follows: T/N pons ratio (T/Np) is the tumor signal intensity/pons signal intensity and T/N muscle ratio (T/Nm) is the tumor signal intensity/temporal muscle signal intensity. Volume measurements were used to assess the tumor size. Growth rate was determined by assessing previous imaging studies. Growing VS was defined as a tumor with a growth rate >100 mm 3 /year.Results: The mean (standard deviation) T/Np and T/Nm were 1.47 (0.27) and 1.50 (0.24), respectively, in nongrowing tumors and 1.78 (0.17) and 1.90 (0.12), respectively, in growing tumors. The T/Np and T/Nm differed significantly between the two groups (T/Np, P < .001; T/Nm, P < .001). Receiver operating characteristic curve analysis showed that cutoffs of 1.56 and 1.76 for T/Np (93.33% sensitivity, 75.00% specificity) and T/Nm (100.00% sensitivity, 93.75% specificity), respectively, could be used to diagnose a growth rate of >100 mm 3 /year. The area under the curve was 0.85 (95% confidence interval, 0.70-1.00) for T/Np and 0.94 (0.82-1.00) for T/Nm. Conclusion: Growing VSs show higher signal intensities on Gd-enhanced MRI. Thus, measuring the signal intensity of VS on Gd-enhanced MRI may aid in predicting VS growth.

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Immunohistochemical Profiles of Matrix Metalloproteinases and Vascular Endothelial Growth Factor Overexpression in the Antoni B Area of Vestibular Schwannomas

Cited by 11 publications

References 41 publications

Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

Vestibular schwannoma with fluid-fluid levels mimicking aneurysm bone cyst

Comparison of the Signal Intensity of Vestibular Schwannoma Between Growing and Nongrowing Tumors

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