Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases

Viðarsdóttir, Halla; Tran, Lena; Nodin, Björn; Jirström, Karin; Planck, Maria; Jönsson, Per; Mattsson, Johanna Sofia Margareta; Botling, Johan; Micke, Patrick; Brunnström, Hans

doi:10.1016/j.humpath.2018.10.009

Cited by 38 publications

(46 citation statements)

References 29 publications

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“…All cases were updated in accordance with the 4th edition of the WHO classification on lung cancer in 2015, 1,20 and the results of several non-NE IHC markers including thyroid transcription factor 1 (TTF-1), napsin A, p40, and cytokeratin 5 have previously been reported. 21,22 For the Southern Swedish Lung Cancer Study cohort, results of some NE IHC markers have previously been briefly presented, 23 but all cases were reevaluated in the present study. As part of the present investigation, 2 cases were reclassified: one as LCNEC (previous NE stainings from the clinical setting were likely false negative), the other as combined LCNEC with a dominating AC component, instead of AC.…”

Section: Study Populationsmentioning

confidence: 99%

“…This cohort of pulmonary metastases was a retrospective, consecutive study from the Skåne University Hospital in Lund, Sweden, covering the years 2000-2014 and, while not excluded, it contained no NE tumors. 21,22 TMAs were previously constructed with 2 cores, 1 mm in diameter, from each pulmonary metastasis and cores were also taken from the primary tumors when available (.70% of the individuals).…”

Section: Study Populationsmentioning

confidence: 99%

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Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers

Staaf

Tran²,

Söderlund³

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The diagnostic distinction of pulmonary neuroendocrine (NE) tumors from non–small cell lung carcinomas (NSCLCs) is clinically relevant for prognostication and treatment. Diagnosis is based on morphology and immunohistochemical staining. Objective.— To determine the diagnostic value of insulinoma-associated protein 1 (INSM1), in comparison with established NE markers, in pulmonary tumors. Design.— Fifty-four pulmonary NE tumors and 632 NSCLCs were stained for INSM1, CD56, chromogranin A, and synaptophysin. In a subset, gene expression data were available for analysis. Also, 419 metastases to the lungs were stained for INSM1. A literature search identified 39 additional studies with data on NE markers in lung cancers from the last 15 years. Seven of these included data on INSM1. Results.— A positive INSM1 staining was seen in 39 of 54 NE tumors (72%) and 6 of 623 NSCLCs (1%). The corresponding numbers were 47 of 54 (87%) and 14 of 626 (2%) for CD56, 30 of 54 (56%) and 6 of 629 (1%) for chromogranin A, and 46 of 54 (85%) and 49 of 630 (8%) for synaptophysin, respectively. Analysis of literature data revealed that CD56 and INSM1 were the best markers for identification of high-grade NE pulmonary tumors when considering both sensitivity and specificity, while synaptophysin also showed good sensitivity. INSM1 gene expression was clearly associated with NE histology. Conclusions.— The solid data of both our and previous studies confirm the diagnostic value of INSM1 as a NE marker in pulmonary pathology. The combination of CD56 with INSM1 and/or synaptophysin should be the first-hand choice to confirm pulmonary high-grade NE tumors. INSM1 gene expression could be used to predict NE tumor histology.

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Section: Study Populationsmentioning

confidence: 99%

Section: Study Populationsmentioning

confidence: 99%

Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers

Staaf

Tran²,

Söderlund³

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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“…The paired box transcription factor PAX8 has long been studied in malignant tumors of the lung [4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. PAX8, which includes a family of cell-lineage transcription factors, is involved in the organogenesis of the thyroid gland and kidney as well as the Müllerian system.…”

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confidence: 99%

Analysis of PAX8 immunohistochemistry in lung cancers: a meta-analysis

Jeong

Kim

Pyo

2020

J Pathol Transl Med

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Background: In this meta-analysis, we aimed to evaluate the PAX8 immunohistochemical expressions in primary lung cancers and metastatic cancers to the lung. Methods: We identified and reviewed relevant articles from the PubMed databases. Ultimately, 18 articles were included in this meta-analysis. PAX8 expression rates were analyzed and compared between primary and metastatic lung cancers. Results: The PAX8 expression rate in primary lung cancers was 0.042 (95% confidence interval [CI], 0.025 to 0.071). PAX8 expression rates of small cell (0.129; 95% CI, 0.022 to 0.496) and non-small cell carcinomas of the lung (0.037; 95% CI, 0.022 to 0.061) were significantly different (p = .049 in a meta-regression test). However, the PAX8 expression rates of adenocarcinoma (0.013; 95% CI, 0.006 to 0.031) and squamous cell carcinoma (0.040; 95% CI, 0.016 to 0.097) were not significantly different. PAX8 expression rates of metastatic carcinomas to the lung varied, ranging from 1.8% to 94.9%. Metastatic carcinomas from the lung to other organs had a PAX8 expression rate of 6.3%. The PAX8 expression rates of metastatic carcinomas from the female genital organs, kidneys, and thyroid gland to the lung were higher than those of other metastatic carcinomas. Conclusions: Primary lung cancers had a low PAX8 expression rate regardless of tumor subtype. However, the PAX8 expression rates of metastatic carcinomas from the female genital organs, kidneys, and thyroid were significantly higher than those of primary lung cancers.

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“…In a recent study conducted on a group of 665 specimens of resected pulmonary cancer and 425 resected metastases, Vidarsdottir et al routinely studied the presence of CK7, CK20, CDX2, CK5, p40, p63, TTF-1, napsin A, GATA3, and PAX8, and demonstrated that primary adenocarcinoma of the lung presented strong positive expression for TTF1 in 90% of cases and for napsin A in 84%, whereas only less than 10% of cases were positive for p63, CDX2, CK20, and GATA3. Additionally, 68% of cases with pulmonary adenocarcinoma presented positive staining for CK7, TTF-1, and napsin A and were negative for the other studied parameters [9]. The authors demonstrated that the presence of TTF1 and CK7 could also be used to differentiate pulmonary adenocarcinoma by squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 88%

“…The authors demonstrated that the presence of TTF1 and CK7 could also be used to differentiate pulmonary adenocarcinoma by squamous cell carcinoma. In the latter histopathological subtype, the positivity of TTF-1 and CK7 was demonstrated in only 3% and 44% of cases, respectively [9].…”

Section: Discussionmentioning

confidence: 96%

Krukenberg Tumor in Association with Ureteral Stenosis Due to Peritoneal Carcinomatosis from Pulmonary Adenocarcinoma: A Case Report

Bălescu

Bejinariu²,

Slaniceanu³

et al. 2020

Medicina

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Krukenberg tumors from pulmonary adenocarcinoma represent an extremely rare situation; only a few cases have been reported. The aim of this paper is to report an unusual such case in which almost complete dysphagia and ureteral stenosis occurred. The 62-year-old patient was initially investigated for dysphagia and weight loss. Computed tomography showed the presence of a thoracic mass compressing the esophagus in association with a few suspect pulmonary and peritoneal nodules, one of them invading the right ureter. A biopsy was performed laparoscopically on the peritoneal nodules. The right adnexa presented an atypical aspect; right adnexectomy was also found. The histopathological and immunohistochemical studies confirmed that the primitive origin was pulmonary adenocarcinoma. Although both peritoneal carcinomatosis and ovarian metastases from pulmonary adenocarcinoma represent a very uncommon situation, this pathology should not be excluded, especially in cases presenting suspect pulmonary lesions.

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Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases

Cited by 38 publications

References 29 publications

Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers

Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers

Analysis of PAX8 immunohistochemistry in lung cancers: a meta-analysis

Krukenberg Tumor in Association with Ureteral Stenosis Due to Peritoneal Carcinomatosis from Pulmonary Adenocarcinoma: A Case Report

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