Immunohistochemical Observations on Pneumonic Lesions Caused by Rhodococcus equi in Foals.

Ishino, Seishi; Kumagai, Kiyotaka; Kuniyoshi, Sawako; Nakazawa, Muneo; Matsuda, Iwao; Oka, Motoi

doi:10.1292/jvms.54.509

Cited by 12 publications

(13 citation statements)

References 13 publications

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“…The microscopic appearance of lungs seemed as in previous reports (6,11,20,21). In mediastinal lymph nodes, inflammatory cell infiltration and necrosis of lymphoid follicles were also observed similarly to the previous reports (8,14).…”

Section: Discussionsupporting

confidence: 87%

“…In some alveoli lumens, pink homogeneous oedema fluid and erythrocytes were observed. Bronchus and bronchioles epitelheliums were hyperplastic, and occasionally desquamated in lumens (Cases 5,8). Peribronchial lymph follicles were hyperplasic in case 4.…”

Section: Resultsmentioning

confidence: 97%

“…The mediastinal lymph nodes were swollen and the cut surface showed yellowish-green in colour and creamy appearance (Cases 7,8,11) (Figures 9, 10). Moreover, macro-pathologic changes were noted in liver ( Cases 8,11,12), kidney (Cases 8, 11) and intestines (Case 8).…”

Section: Resultsmentioning

confidence: 99%

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The pathological findings of Rhodococcus equi infection and its diagnosis with immunoperoxidase technique in foals

;HAZIROĞLU¹

2009

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Twelve foals with difficulty in respiration that have died during spring-summer months between 2003-2006 years were necropsied. On necropsy, pneumonia was detected in all of the foals. In 5 animals, caseo-necrotic nodules were seen in the lungs. In histopathological examination, purulent bronchopneumonia was noticed. In immunohistochemical staining, Rhodococus equi antigens were determined in the cytoplasm of macrophages and occasionally in neutrophils in lungs and mediastinal lymph nodes by immunoperoxidase technique. No lesions were detected in the intestines confirming that this form of infection is rare compared to the lung form. In the present study, R. equi was microbiologically isolated only in two cases. In conclusion, R. equi infection was diagnosed in all of the twelve cases, and estimated to be the reason of pneumonia in the foals. It was also shown that immunoperoxidase technique can be successfully used for R. equi infection in the field.

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Section: Discussionsupporting

confidence: 87%

Section: Resultsmentioning

confidence: 97%

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The pathological findings of Rhodococcus equi infection and its diagnosis with immunoperoxidase technique in foals

;HAZIROĞLU¹

2009

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Ultrastructural examination showed that most of the R. equi microorganisms appeared intact. These (273). In addition, cells containing intracytoplasmic immunoglobulin M, immunoglobulin G, and immunoglobulin A were noticeably few in number and scattered predominantly around the lesions in R. equiinduced pneumonia (273).…”

Section: Downloaded Frommentioning

confidence: 97%

“…These (273). In addition, cells containing intracytoplasmic immunoglobulin M, immunoglobulin G, and immunoglobulin A were noticeably few in number and scattered predominantly around the lesions in R. equiinduced pneumonia (273). However, Hietala and Ardans showed that lymphocyte factors derived by in vitro incubation of sensitized peripheral blood lymphocytes with R. equi surface antigens enhanced macrophage bactericidal activity (252).…”

Section: Downloaded Frommentioning

confidence: 99%

The medically important aerobic actinomycetes: epidemiology and microbiology

1994

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The aerobic actinomycetes are soil-inhabiting microorganisms that occur worldwide. In 1888, Nocard first recognized the pathogenic potential of this group of microorganisms. Since then, several aerobic actinomycetes have been a major source of interest for the commercial drug industry and have proved to be extremely useful microorganisms for producing novel antimicrobial agents. They have also been well known as potential veterinary pathogens affecting many different animal species. The medically important aerobic actinomycetes may cause significant morbidity and mortality, in particular in highly susceptible severely immunocompromised patients, including transplant recipients and patients infected with human immunodeficiency virus. However, the diagnosis of these infections may be difficult, and effective antimicrobial therapy may be complicated by antimicrobial resistance. The taxonomy of these microorganisms has been problematic. In recent revisions of their classification, new pathogenic species have been recognized. The development of additional and more reliable diagnostic tests and of a standardized method for antimicrobial susceptibility testing and the application of molecular techniques for the diagnosis and subtyping of these microorganisms are needed to better diagnose and treat infected patients and to identify effective control measures for these unusual pathogens. We review the epidemiology and microbiology of the major medically important aerobic actinomycetes.

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Rhodococcus equi

Hines¹

2007

Equine Infectious Diseases

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Immunohistochemical Observations on Pneumonic Lesions Caused by Rhodococcus equi in Foals.

Cited by 12 publications

References 13 publications

The pathological findings of Rhodococcus equi infection and its diagnosis with immunoperoxidase technique in foals

The pathological findings of Rhodococcus equi infection and its diagnosis with immunoperoxidase technique in foals

The medically important aerobic actinomycetes: epidemiology and microbiology

Rhodococcus equi

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