Immunohistochemical Observation of HSP27 in Ameloblastomas

Fujita, Muneteru; Nakano, Keisuke; Maeda, Hideaki; Yoshida, Waka; Torii, Ryota; Yoshiyama, Masanori; Okafuji, Norimasa; Hasegawa, Hiromasa; Kawakami, Toshiyuki

doi:10.2485/jhtb.20.289

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…2, 3. Search of literatures revealed no other studies on HSPs in ameloblastoma with exception of two studies 4,5. The one revealed that HSP27 localized in human tooth germ is essential in cell growth.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the expression of HSP27 in ameloblastoma suggested its essential role in tumor development 4. The later, the localization and differential expressions of HSP27 and phosphorylated HSP27 (pHSP27) in histopathological subtypes of ameloblastoma were investigated suggesting the role of HSP27 in the differentiation of tumor cells 5. However, since the results were based on a limited number of specimens, new a large number of cases were added to previous cases stained with HSP27/pHSP27.…”

Section: Introductionmentioning

confidence: 99%

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Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas

et al. 2013

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The expression of HSP27 and some CKs were examined the 40 cases of typical solid/multicystic ameloblastoma using immunohistochemical techniques. In order to examine the relevance of HSP in cell differentiation, we focused on the cytoskeletal expression of CK. CK19 is a marker of typical odontogenic epithelium widely observed in follicular and plexiform types of ameloblastomas. Since staining with CK14 is one of the measures of the differentiation potential of squamous cells and is extensively expressed in both follicular and plexiform types, it implies that squamous differentiation of each type can occur. CK8 was strongly detected in tumor nests in plexiform type but weakly detected in follicular type. It was considered that the expression of HSP27 in plexiform type correlated with the expression of CK8 suggesting that HSP27 might have regulated the expression of CK8.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas

et al. 2013

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“…Also the expression of Hsp27 in ameloblastoma in his study was attributed towards tumor development. Fujita M, et al emphasize the role of Hsp 27 in differentiation of tumor cells after observing the localization and differential expressions in histopathological subtypes of ameloblastoma [109,110].…”

Section: Role In Infectionmentioning

confidence: 99%

Cytotoxic or cytoprotective chaperones: An unfolded biology in oral lesions

Kashyap¹,

P²,

Rajguru³

2017

Clin Res Trials

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Heat shock proteins (Hsp) or the molecular chaperones are observed in most cells of humans, microbes, and in extracellular and intracellular fluids. Hsps plays an essential role under most stress conditions at the cellular and subcellular levels. It presents cytoprotective properties by the modulation of cytokine release and immunity and is involved in various physiological and pathological events. A tight regulation of molecular chaperones monitors the folding/misfolding, internal localization, and proteolytic turnover of proteins. Despite their advantageous effects, Hsps also has disadvantageous role in intensifying the inflammation. They are potential mediators of oncogenesis as they are the key regulators of cellular growth and differentiation. The authors reviewed, an overview of the role of chaperones, with respect to the lesions affecting oral and para-oral structures.

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Immunohistochemical Observation of HSP27 in Ameloblastomas

Cited by 2 publications

References 18 publications

Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas

Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas

Cytotoxic or cytoprotective chaperones: An unfolded biology in oral lesions

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