Immunohistochemical localization of estrogen receptor in rat brain, pituitary and uterus with monoclonal antibodies

Gene expression of steroid hormone receptors in brain and peripheral tissues relative to reproduction.

“…8B) 3) Discussion The in situ hybridization findings reported here demonstrated selective distribution of ERmRNA in the central hypothalamus, amygdala and uterus. The sites of ERmRNA-containing neurons were largely in agreement with those of ER in the previous autoradiographical (40) and immunohistochemical (48) studies, and with the in situ hybridization ones (42,43,50). Discrepancy exists, however, on the existence of ERmRNA in the amygdala between ours and Pelletier's (42).…”

“…Our preliminary results have revealed the existence of ERmRNA even in poorly differentiated cancers in which ERs are absent, implying different regulation of the ER level in the cancer lacking in hormone dependency. Several in situ hybridization studies have reported the distribution of ERmRNA containing neurons in the rat brain (42,43,50), which is roughly similar as that of ER (40,48).…”

Excretion and binding of tritium-labelled oestradiol in mice (Mus musculus): implications for the Bruce effect

“…injected males. We then tested the binding of intranasally administered 3 H-E 2 in inseminated female mice, examining diverse tissues that vary in oestrogen receptor concentration (Eisenfeld & Axelrod 1966, Pfaff 1968, Stumpf 1969, Pfaff & Keiner 1973, Gorzalka & Whalen 1974, Sar & Parikh 1986, Simerly et al 1990, including areas in the reproductive system and brain. We also intranasally administered male urine collected from males injected with 3 H-E 2 to inseminated females, and target tissues were examined for 3 H-E 2 uptake.…”

Antiestrógenos: mecanismo de acción y aplicaciones clínicas

“…Los estrógenos son hormonas esteroides que ejercen múltiples efectos, principalmente sobre la proliferación y diferenciación celular en diversos órganos, como hipotálamo, 6 hipófisis, 7 útero, 8 mama, 9 ovario, 10 hueso e hígado. [11][12] Su acción en el ámbito celular se ejerce a través de un receptor nuclear específico, conocido como receptor de estrógenos (RE), el cual también es utilizado por los antiestrógenos, bloqueando de esta manera la expresión de genes, acción que depende del estímulo estrogénico.…”