Immunohistochemical Localization of Cytokines in Nevi

Fleming, Matthew G.; Howe, Susan F.; Candel, Antimo G.

doi:10.1097/00000372-199212000-00002

Cited by 21 publications

(9 citation statements)

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“…Rudolph et al (18), assessing growth fraction with two monoclonal antibodies (Ki-S1 and Ki-55), found it to be constantly higher in the epidermal-junctional compartment than in the dermal aggregations of compound nevi. Basic fibroblast growth factor has been identified in the basement membranes at the dermal-epidermal junction and surrounding nevus cell nests and individual cells at that site (19). These findings suggest a role for MGSA as a local growth factor in proliferation of acquired melanocytic nevi.…”

Section: Discussionmentioning

confidence: 81%

Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

et al. 2002

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Section: Discussionmentioning

confidence: 81%

Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

et al. 2002

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“…[19][20][21][22][23][24] The simplest explanation for this would be impairment of neurocutaneous development in association with nevogenesis; but there are many other possibilities. If a nevus has its onset before dermal collagenization accelerates after 4 months gestation, collagenization may develop around the pre-existing singly dispersed deep dermal melanocytes demonstrated in this study.…”

Section: Single-cell Infiltration In Deep Dermis Of Prenatal Nevimentioning

confidence: 99%

“…Nerve growth factor, basic fibroblast growth factor, and other substances may also play a role. [19][20][21][22][23][24] These stem cells may persist in nerve endings in postnatal skin, producing transient inconspicuous dermal melanocytes to provide replacements when epidermal melanocytes are damaged. 16,[25][26][27] It is not known how variations in nerve density may relate to regional variations in melanocyte density.…”

Section: Introductionmentioning

confidence: 99%

On the Development of Neurocutaneous Units—Implications for the Histogenesis of Congenital, Acquired, and Dysplastic Nevi

Cramer

Fesyuk²

2012

The American Journal of Dermatopathology

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This study of spontaneous abortions and fetal deaths in utero used immunostains to evaluate the structure of developing cutaneous nerves. Melan-A immunostains were also used to screen 25 cases of grossly normal fetal skin for occult fetal nevi. Discrete portions of epidermis were generally supplied by branches emanating from regularly spaced deep cutaneous nerves, producing a wedge shape, interpreted as neurocutaneous units (NCU). Deeper nerves embraced broader portions of epidermis. Some nerves ran parallel to epidermis, especially near the superficial vascular plexus at the junction of superficial and deep dermis. Nerve sheath stem cells in each NCU may supply the melanocytes needed by the corresponding portion of epidermis. Transformed nerve sheath stem cells may lead to formation of occult prenatal nevi, whose histology and histogenesis may best be understood in terms of NCUs. In particular, the size and shape of a nevus may be largely determined by its NCU of origin. Six fetal nevi were detected, and 3 occult lumbosacral Mongolian spots; all in deep dermis, no later than the middle of the second trimester, mainly with a pattern of singly dispersed deep dermal melanocytes. These findings suggest that congenital (prenatal) nevi begin as intradermal nevi. In addition to explaining congenital nevi, these findings have implications for the histogenesis of acquired (postnatal) nevi and dysplastic nevi.

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“…The latter two observations provide evidence for bFGF as a potential mediator of fibrosis in vivo (28,29). Fleming et al have also suggested that bFGF might be a factor in the development of the dermal fibrosis that is frequently observed in melanocytic nevi (30). Recently, bFGF expression has been noted in areas of fibroplasia within both dysplastic nevi and regressing melanoma (31).…”

Section: Discussionmentioning

confidence: 99%

Expression of basic fibroblast growth factor in desmoplastic melanoma

et al. 1996

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Basic fibroblast growth factor (bFGF) is an established growth factor for melanocytes and a potent angiogenic factor. The expression of bFGF was investigated in 23 desmoplastic melanomas. (DM) (12 males, median age 64 years, and 11 females, median age 54 years) by immunostaining of formalin-fixed, paraffin-embedded sections with high-affinity purified antibody raised against recombinant human bFGF (Scios Nova, Inc.). The tumors were characterized by level II invasion in 1 case (5%), level IV invasion in 11 cases (48%), level V invasion in 8 cases (35%), and indeterminate in 3 cases. bFGF expression was observed in 22 of 23 tumors (95%), either immune localized to tumor cell nuclei in 17 of 22 tumors (77%), or to the cytoplasm of tumor cells in 5 of 22 tumors (23%). Also in these cases, bFGF was strongly expressed in the nuclei of vascular endothelial cells. Maximal expression was noted in the peripheral blood vessels of 20 tumors (91%) versus intratumoral vessels of 13 DM (59%). In conclusion, the expression of predominantly nuclear bFGF by tumor cells in DM suggests a role in mediating the desmoplastic phenotype. In addition, the localization of bFGF to vascular endothelium, particularly at the periphery of the tumor, may be relevant to tumor angiogenesis.

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Immunohistochemical Localization of Cytokines in Nevi

Cited by 21 publications

References 0 publications

Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

On the Development of Neurocutaneous Units—Implications for the Histogenesis of Congenital, Acquired, and Dysplastic Nevi

Expression of basic fibroblast growth factor in desmoplastic melanoma

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