Immunohistochemical localization of androgen and oestrogen receptors in canine hair follicles

Bratka‐Robia, Christine B.; Egerbacher, Monika; Helmreich, M.; Mitteregger, Gerda; Benesch, Michael; Bamberg, E.

doi:10.1046/j.1365-3164.2002.00287.x

Cited by 21 publications

(34 citation statements)

References 11 publications

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“…Together with the fact that E2 modifies androgen metabolism and vice versa (250,251) and the intriguing cross talk examples discussed above, this already renders the number of potential signaling cross talks and cross-modulation events that may impact how E2 can alter the growth of a given hair follicle in a defined gender and location daunting. This gets even more complicated if one enters additional recent findings into the equation.…”

Section: H Other Potentially Important Signaling Cross Talks With Inmentioning

confidence: 99%

The Hair Follicle as an Estrogen Target and Source

et al. 2006

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For many decades, androgens have dominated endocrine research in hair growth control. Androgen metabolism and the androgen receptor currently are the key targets for systemic, pharmacological hair growth control in clinical medicine. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs). Besides altering the transcription of genes with estrogen-responsive elements, 17␤-estradiol (E2) also modifies androgen metabolism within distinct subunits of the pilosebaceous unit (i.e., hair follicle and sebaceous gland). The latter displays prominent aromatase activity, the key enzyme for androgen conversion to E2, and is both an estrogen source and target.Here, we chart the recent renaissance of estrogen research in hair research; explain why the hair follicle offers an ideal, clinically relevant test system for studying the role of sex steroids, their receptors, and interactions in neuroectodermal-mesodermal interaction systems in general; and illustrate how it can be exploited to identify novel functions and signaling cross talks of ER-mediated signaling. Emphasizing the long-underestimated complexity and species-, gender-, and site-dependence of E2-induced biological effects on the hair follicle, we explore targets for pharmacological intervention in clinically relevant hair cycle manipulation, ranging from androgenetic alopecia and hirsutism via telogen effluvium to chemotherapy-induced alopecia. While defining major open questions, unsolved clinical challenges, and particularly promising research avenues in this area, we argue that the time has come to pay estrogen-mediated signaling the full attention it deserves in future endocrinological therapy of common hair growth disorders. (Endocrine Reviews 27: 677-706, 2006)

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Section: H Other Potentially Important Signaling Cross Talks With Inmentioning

confidence: 99%

The Hair Follicle as an Estrogen Target and Source

et al. 2006

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“…There is a pattern of alopecia, with hair loss at the predilection sites of flanks, perineum and neck, while other areas are typically spared. Patterns of alopecia have been explained by regionalization of hormone receptor numbers, but recent studies could not detect significant differences in the number of hormone receptors in different anatomical locations 2,3 . The reason that the alopecia affects those areas remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical localization of fibroblast growth factor 18 in hair follicles of healthy beagle dogs

Vandenabeele

Daminet

Ham

et al. 2011

Veterinary Dermatology

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Increasing emphasis is being placed on the role of fibroblast growth factors (FGFs) in hair follicle cycling. In mice, expression of FGF18 mRNA peaks during the late telogen phase, leading to the hypothesis that FGF plays a role in anagen induction. There are no data on the presence of FGF18 in dogs. The main objective of this study was to identify and locate FGF18 in the canine hair follicle. The second objective was to assess potential differences in FGF18 concentration between biopsies taken in winter and summer, shoulder and flank regions, and between different sexes. Skin tissue from 10 healthy beagle dogs (three intact females, three spayed females and four intact males) was collected from the shoulder and flank. The biopsies were collected in February and August on day 0, after which the dogs were clipped and biopsies collected again from the shoulder and flank on days 1, 3, 7 and 17. Paraffin sections (4 μm thick) of the biopsies were stained with an anti-FGF18 antibody. The FGF18-positive cells were counted in the hair follicle epithelium from seven follicular units of each biopsy. Fibroblast growth factor 18 was detected as granular cytoplasmatic staining in follicles at the level of the inner root sheath, and rarely in the outer root sheath and dermal papilla. It was also detected in the apocrine glands, in arrector pili muscles and in vascular endothelial cells. There was no statistical difference in the number of FGF18-positive cells or follicles between sexes, different anatomical locations, seasons or the consecutive days of sampling.

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“…As in previous studies, 1,5 pyotraumatic dermatitis was significantly more common in dogs aged less than 4 years. The high incidence in male dogs, particularly younger dogs, may correlate with coat thickness and hormonal effects on skin secretions and infection 14 or indicate a temperamental tendency to scratching and self‐trauma.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of the clinical findings, treatment and histopathology of 44 cases of pyotraumatic dermatitis

Holm¹,

Rest²,

Seewald

2004

Veterinary Dermatology

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Pyotraumatic dermatitis (hot spot) is a common clinical syndrome in dogs but there are few prospective scientific studies related to it. The aim of this study was to investigate correlations among clinical pyotraumatic dermatitis, histopathology of the lesions and possible predisposing causes. The relationship of these with breed, age, sex and location of lesion was assessed statistically. A clinical diagnosis of acute pyotraumatic dermatitis was made in 44 privately owned dogs. Males exceeded females (P = 0.0348) and lesions were more common in dogs aged 4 years or less (P < 0.0001). Lesions were most often seen on the cheek, neck and lateral thigh with a significant correlation between breed and site of lesion (P < 0.0001). In 31 cases a possible underlying cause was found or suspected. In contrast to previous studies, no otitis externa was recorded and the study was conducted in an area without endemic fleas. Fourteen breeds were represented of which Rottweiler, German shepherd dog and golden retriever were most common. There was no significant seasonal incidence and no correlation among site of lesion and cause, time of year, age or sex. Histopathologically, the dogs could be separated into four patterns by the presence or absence of eosinophils and/or folliculitis. Eosinophils have not previously been recorded in pyotraumatic dermatitis but were seen in 29 cases. Acute folliculitis was seen in 20 cases. However, no correlation was seen among age, sex, breed, underlying cause or site of lesion and histopathology. Twenty-seven cases were cultured for bacteria of which 25 grew Staphylococcus intermedius and two were negative.

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Immunohistochemical localization of androgen and oestrogen receptors in canine hair follicles

Cited by 21 publications

References 11 publications

The Hair Follicle as an Estrogen Target and Source

The Hair Follicle as an Estrogen Target and Source

Immunohistochemical localization of fibroblast growth factor 18 in hair follicles of healthy beagle dogs

A prospective study of the clinical findings, treatment and histopathology of 44 cases of pyotraumatic dermatitis

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