Immunohistochemical investigation of secretory component and immunoglobulin A in the genital tract of the female rat

Parr, Margaret B.; Parr, Earl L.

doi:10.1530/jrf.0.0850105

Cited by 24 publications

(15 citation statements)

References 16 publications

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“…Serum levels of SIgA have been reported to increase during pregnancy (Wilson and Ganendren, 1992), although the tissue of origin of pIgR/SC is not clear. In rat uterine and vaginal tissues, and in uterine secretions, pIgR and SC levels were found to be the highest at proestrus, intermediate at estrus, and the lowest during diestrus Parr and Parr, 1989a;Kaushic et al, 1995). However, SC and SIgA levels in vaginal secretions were maximal at estrus and reduced at all other stages of the cycle , perhaps reflecting differences in the rate of secretion or stability of SC.…”

Section: Regulation Of Pigr Expression By Cytokines and Hormonesmentioning

confidence: 92%

“…Immunohistochemical studies in humans and rats demonstrated that expression of pIgR is compartmentalized within female reproductive tissues (Tourville et al, 1970;Kutteh et al, 1988Kutteh et al, , 1990Parr and Parr, 1989a;Bjercke and Brandtzaeg, 1993;Kutteh and Mestecky, 1994;Kaushic et al, 1995;Fichorova and Anderson, 1999) and is profoundly influenced by hormonal changes in the menstrual or estrus cycle (see subsequent section, Regulation of pIgR Expression by Cytokines and Hormones). Staining for pIgR was strongest in the columnar epithelial cells of the fallopian tubes, endometrial glands, and endocervix; was weak but detectable in the squamous epithelium of the ectocervix and vagina; and was absent in the ovaries and myometrium.…”

Section: Tissue-specific Expression Of Pigrmentioning

confidence: 99%

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Immunoglobulin Transport and Immunoglobulin Receptors

2015

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Section: Regulation Of Pigr Expression By Cytokines and Hormonesmentioning

confidence: 92%

Section: Tissue-specific Expression Of Pigrmentioning

confidence: 99%

Immunoglobulin Transport and Immunoglobulin Receptors

2015

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“…Although the reproductive tracts of males and females both exhibit immunologic characteristics indicating they are tissues of the mucosal immune system (9,10,26,28,29,(40)(41)(42)46), the male and female reproductive tracts are obviously anatomically and functionally distinct. Therefore, we evaluated antigen-specific IFN-␥ responses in the colons of mice immunized with our prime-boost immunization strategies.…”

Section: Vol 78 2004 Effects Of Gender On Vaccine T-cell Responses mentioning

confidence: 99%

Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Peacock¹,

Nordone²,

Jackson

et al. 2004

J Virol

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Induction of mucosal anti-human immunodeficiency virus type 1 (HIV-1) T-cell responses in males andfemales will be important for the development of a successful HIV-1 vaccine. An HIV-1 envelope peptide, DNA plasmid, and recombinant modified vaccinia virus Ankara (rMVA) expressing the H-2D d -restricted cytotoxic T lymphocyte P18 epitope were used as immunogens to test for their ability to prime and boost anti-HIV-1 T-cell responses at mucosal and systemic sites in BALB/c mice. We found of all prime-boost combinations tested, an HIV-1 Env peptide subunit mucosal prime followed by systemic (intradermal) boosting with rMVA yielded the maximal induction of gamma interferon (IFN-␥) spot-forming cells in the female genital tract and colon. However, this mucosal prime-systemic rMVA boost regimen was minimally immunogenic for the induction of genital, colon, or lung anti-HIV-1 T-cell responses in male mice. We determined that a mucosal Env subunit immunization could optimally prime an rMVA boost in female but not male mice, as determined by the magnitude of antigen-specific IFN-␥ responses in the reproductive tracts, colon, and lung. Defective mucosal priming in male mice could not be overcome by multiple mucosal immunizations. However, rMVA priming followed by an rMVA boost was the optimal prime-boost strategy for male mice as determined by the magnitude of antigen-specific IFN-␥ responses in the reproductive tract and lung. Thus, prime-boost immunization strategies able to induce mucosal antigen-specific IFN-␥ responses were identified for male and female mice. Understanding the cellular and molecular basis of gender-determined immune responses will be important for optimizing induction of anti-HIV-1 mucosal immune responses in both males and females.

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“…Secretory component (SC) in the uterine epithelium (Parr & Parr, 1989) suggests that serum IgA might be transported into the uterine lumen by a mechanism analogous to the SC-mediated transport of IgA into biliary, lacrimal, salivary and mammary secretions (Jackson et al, 1978;Sheldrake et al, 1984;Underdown & Schiff, 1986;Mestecky et al, 1978). In contrast, cervicovaginal tissue displays hallmarks of local immunity (Tourville et al, 1970;Waldman et al, 1971 ;Rebello et al, 1975;Kutteh et al, 1988).…”

confidence: 99%