Immunohistochemical identification of primary peritoneal serous cystadenocarcinoma mimicking advanced colorectal carcinoma: a case report

Riedenauer, Wesley B. von; Janjua, Sumbul A; Kwon, David S.; Zhang, Ziying; Velanovich, Vic

doi:10.1186/1752-1947-1-150

Cited by 10 publications

(6 citation statements)

References 11 publications

(23 reference statements)

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“…Generally, CK7 is present in serous carcinomas but absent in gastrointestinal carcinomas. Contrarily, CK20 is common in gastrointestinal carcinoma but rare in serous carcinoma [16]. Although the positive rate for CK20 in our PPSPC cases was 31.8%, which is litter higher than the 10% to 30% rate previously reported, the combination of CK7 and CK20 markers provide more accurate prediction in distinguishing PPSPC from PMM [17].…”

Section: Discussioncontrasting

confidence: 50%

Primary Peritoneal Serous Papillary Carcinoma: A Clinical and Pathological Study

Liu

Lin

Shi

et al. 2011

Pathol. Oncol. Res.

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Primary peritoneal serous papillary carcinoma (PPSPC) is a rare primary tumor of the peritoneum that found predominantly in elderly and post-menopausal women. The aim of our study is to review the clinical and pathologic information of 22 patients, and then try to summarize clinical behavior and pathological characteristics of PPSPC, in order to be better recognized of this entity in future. We retrospectively reviewed the data from 22 patients with PPSPC treated at our hospital from 1992 to 2008. All paraffin blocks were recut for periodic acid-Schiff diastase and immunohistochemical staining for CD15, cytokeratin7(CK7), cytokeratin20(CK20), S-100 protein, carcinoembryonic antigen (CEA), CA125, estrogen receptor(ER) and progesterone receptor(PR). The median age of the patients at the time of surgical staging was 56 years (range, 32-77 years). The most common presenting symptoms were abdominal distension (59.1%) and ascites (63.6%). Pretreatment CA125 levels were significant elevated in 90.5% patients. Optimal debulking was performed in 18 patients. All patients were consequently treated with platinum-based chemotherapy. Response to treatment is promising, and the median overall survival of all patients was 21.0 months (95% CI 16.9, 25.1 months). The positive rate of immunohistochemical staining was CD15 95.5%, CK7 90.9%, S-100 protein 68.2%, CA125 59.1%, CK20 31.8%, ER 31.8%, CEA 27.3% and PR 9.1%, respectively. Gynecologist should be aware of PPSPC when abdominal distension, gross ascites and a raised level of CA125 in women without ovarian enlargement. Immunohistochemical staining might be helpful as accessory criteria for the differential diagnosis among the PPSPC, peritoneal malignant mesothelioma (PMM), primary epithelial ovarian carcinoma (PEOC) and peritoneal carcinomatosis from the gastrointestinal tumors (SPCGT). Cytoreductive surgery combined with pre/postoperative platinum-based chemotherapy may be effective for PPSPC patients.

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Section: Discussioncontrasting

confidence: 50%

Primary Peritoneal Serous Papillary Carcinoma: A Clinical and Pathological Study

Liu

Lin

Shi

et al. 2011

Pathol. Oncol. Res.

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“…Direct invasion of the gastrointestinal tract by PSPC is even more rarer. To date, only 10 cases of invasion of the colon by PSPC have been reported in the literature (6)(7)(8)(9)(10)(11). In all of these patients, omental tumors with dissemination to the abdominal and pelvic peritoneum were found.…”

Section: Discussionmentioning

confidence: 99%

Primary Peritoneal Serous Papillary Carcinoma Presenting as a Single Colonic Mass without Peritoneal Dissemination

et al. 2013

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Peritoneal serous papillary carcinoma (PSPC), a rare primary malignancy arising from the abdominal and pelvic peritoneum, is characterized by peritoneal carcinomatosis with ascites and a histological pattern similar to that of papillary serous ovarian carcinoma. We herein describe a rare case of PSPC with unusual clinical presentations involving a single primary tumor originating from the peritoneal lining of the sigmoid colon with no evidence of intraperitoneal spread, pelvic lymph node involvement or distant metastasis. Awareness of such unusual presentations of PSPC should assist in the diagnosis of this disease, thereby improving the management of patients with this condition.

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“…However, PET/CT is beneficial due to its ability to define the extent of metabolically active disease and its ability to detect distant metastasis. Therefore, PET/CT is beneficial for the differentiation of PPSC from ovarian cancer (9).…”

Section: Discussionmentioning

confidence: 99%

Primary peritoneal serous carcinoma, an extremely rare malignancy: A case report and review of the literature

Yun¹,

Bae²

2016

Oncology Letters

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Abstract. Primary peritoneal serous carcinoma (PPSC) is an extremely rare malignancy that was first described in 1959. This type of cancer arises from the peritoneal epithelium and is similar to serous ovarian carcinoma. A diagnosis of PPSC is typically made based on the Gynecology Oncology Group criteria; however, a correct differential diagnosis of PPSC is difficult preoperatively. The current study describes the case of a 66 year-old female patient presenting with abdomen distension. A computed tomography (CT) scan revealed abundant ascites in the abdominal cavity and omental infiltration. The results of positron emission tomography/CT showed hot uptake in the greater omentum. Furthermore, preoperative serum cancer antigen-125 levels were 1,032 U/ml. Upon surgical exploration, a whitish mass and nodule were found in the greater omentum. Therefore, omentectomy was performed. Pathological examination of the resected specimen revealed a diagnosis of PPSC. PPSC is extremely rare with few cases cited in the current literature. The present study describes a rare case of PPSC with a review of the literature.

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Immunohistochemical identification of primary peritoneal serous cystadenocarcinoma mimicking advanced colorectal carcinoma: a case report

Cited by 10 publications

References 11 publications

Primary Peritoneal Serous Papillary Carcinoma: A Clinical and Pathological Study

Primary Peritoneal Serous Papillary Carcinoma: A Clinical and Pathological Study

Primary Peritoneal Serous Papillary Carcinoma Presenting as a Single Colonic Mass without Peritoneal Dissemination

Primary peritoneal serous carcinoma, an extremely rare malignancy: A case report and review of the literature

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