Immunohistochemical fluorescence intensity reduction of brain somatostatin in the impairment of learning and memory-related behaviour induced by olfactory bulbectomy

Nakagawasai, Osamu; Hozumi, Soichi; Tan-No, Koichi; Niijima, Fukie; Arai, Yasuhiko; Yasuhara, Hajime; Tadano, Takeshi

doi:10.1016/s0166-4328(02)00383-2

Cited by 36 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the one hand, a positive correlation between performance in hippocampus-dependent learning tasks and the amount of endogenously expressed somatostatin has been observed in various studies (Nilsson et al 1993;Nakagawasai et al 2000Nakagawasai et al , 2003. Moreover, intracerebroventricular application of somatostatin facilitated memory and comprised a mitigating effect upon experimentally induced retrograde amnesia (Vecsei et al 1983(Vecsei et al , 1984Lamirault et al 2001).…”

Section: Discussionmentioning

confidence: 96%

“…In view of the critical role of both the hippocampus and the amygdala in associative (fear) memory formation, it comes as no surprise that an involvement of somatostatin has been implicated in amygdala-and hippocampusdriven cognitive and emotional functions (Vecsei and Widerlov 1990;Schettini 1991). Animal studies, for example, have shown a correlation between memory performance in hippocampusdependent tasks and the amount of endogenously expressed somatostatin (Nilsson et al 1993;Nakagawasai et al 2000Nakagawasai et al , 2003 and recently also in the pathology of Alzheimer's disease (Davies et al 1980;Saito et al 2005), an ailment in which hippocampal memory deficits are a prominent clinical feature. However, the precise role of somatostatin in these processes is still poorly understood.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity

Kluge¹,

Stoppel²,

Szinyei³

et al. 2008

Learn. Mem.

View full text Add to dashboard Cite

Somatostatin has been implicated in various cognitive and emotional functions, but its precise role is still poorly understood. Here, we have made use of mice with somatostatin deficiency, based upon genetic invalidation or pharmacologically induced depletion, and Pavlovian fear conditioning in order to address the contribution of the somatostatin system to associative fear memory. The results demonstrate an impairment of foreground and background contextual but not tone fear conditioning in mice with targeted ablation of the somatostatin gene. These deficits were associated with a decrease in long-term potentiation in the CA1 area of the hippocampus. Both the behavioral and the electrophysiological phenotypes were mimicked in wild-type mice through application of the somatostatin-depleting substance cysteamine prior to fear training, whereas no further deficits were observed upon application in the somatostatin null mutants. These results suggest that the somatostatin system plays a critical role in the acquisition of contextual fear memory, but not tone fear learning, and further highlights the role of hippocampal synaptic plasticity for information processing concerning contextual information.

show abstract

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity

Kluge¹,

Stoppel²,

Szinyei³

et al. 2008

Learn. Mem.

View full text Add to dashboard Cite

show abstract

“…These modifications include increased immobility time in the forced swimming test (Vieyra-Reyes et al, 2008), difficulty adapting to new environments (Song and Leonard, 2005), reduced social interaction (Wang et al, 2007;Morales-Medina et al, 2012), and memory deficits (Nakagawasai et al, 2003;Morales-Medina et al, 2013), among others. The present study investigated the ability of repeated treatment with quercetin to reverse induced OB-depressive behavior (hyperactivity on open field test, immobility in the forced swimming and tail suspension tests and anhedonic behavior in the splash test).…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Holzmann

Silva

et al. 2015

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

“…Immunohistochemical staining was conducted as previously described (Nakagawasai et al, 2003;Nemoto et al, 2013Nemoto et al, , 2014Nemoto et al, , 2015b. The quantities of Ang II, phospho-p38 MAPK, ACE, AT1 receptors, or AGT in spinal cords [lumbar 5 (L5)] were determined as follows: 20-mm-thick slices were incubated overnight at 4°C with rabbit anti-Ang II antibody (diluted 1:50 with PBS containing 0.3% Triton X-100 and 1% NGS), rabbit anti-phospho-p38 MAPK antibody (1:100 dilution with PBS containing 1% NGS and 0.3% Triton X-100), rabbit anti-ACE antibody (1:50 dilution with PBS containing 1% NGS), rabbit anti-AT1 receptor antibody (1:100 dilution with PBS containing 1% NGS), or rabbit anti-AGT antibody (1:25 dilution with PBS containing 1% NGS and 0.3% Triton X-100), respectively.…”

Section: Immunohistochemical Studymentioning

confidence: 99%

Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice

et al. 2016

Self Cite

View full text Add to dashboard Cite

Renin-angiotensin system (RAS) activity increases under hyperglycemic states, and is thought to be involved in diabetic complications. We previously demonstrated that angiotensin (Ang) II, a main bioactive component of the RAS, might act as a neurotransmitter and/or neuromodulator in the transmission of nociceptive information in the spinal cord. Here, we examined whether the spinal Ang II system is responsible for diabetic neuropathic pain induced by streptozotocin (STZ). Tactile allodynia was observed concurrently with an increase in blood glucose levels the day after mice received STZ (200 mg/kg, i.v.) injections. Tactile allodynia on day 14 was dose-dependently inhibited by intrathecal administration of losartan, an Ang II type 1 (AT1) receptor antagonist, but not by PD123319, an AT2 receptor antagonist. In the lumbar dorsal spinal cord, the expression of Ang II, Ang converting enzyme (ACE), and phosphop38 mitogen-activated protein kinase (MAPK) were all significantly increased on day 14 after STZ injection compared with vehicletreated controls, whereas no differences were observed among AT1 receptors or angiotensinogen levels. Moreover, the increase in phospho-p38 MAPK was significantly inhibited by intrathecal administration of losartan. These results indicate that the expression of spinal ACE increased in STZ-induced diabetic mice, which in turn led to an increase in Ang II levels and tactile allodynia. This increase in spinal Ang II was accompanied by the phosphorylation of p38 MAPK, which was shown to be mediated by AT1 receptors.

show abstract

Immunohistochemical fluorescence intensity reduction of brain somatostatin in the impairment of learning and memory-related behaviour induced by olfactory bulbectomy

Cited by 36 publications

References 30 publications

Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity

Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice

Contact Info

Product

Resources

About