Immunohistochemical findings in small cell neuroendocrine carcinoma of the cervix: a report of two cases

Zhou, Hongrun; Lin, Tong; Chen, Dongdong; Gao, Ruijuan; Zhao, Lili; Li, Ganxiong; Chen, Hongzhi; Ren, Yan; Li, Xiaoyü; Wang, Yixun; Pang, Lijuan

doi:10.21037/tcr.2017.07.15

Cited by 2 publications

(1 citation statement)

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“…Hematoxylin and eosin staining: For paraffin-embedded tissue specimens, consecutive 3-5 µm thick sections were cut and used for histological analysis[7]. Hematoxylin and eosin staining revealed moderately differentiated SCC.…”

Section: Case Presentationmentioning

confidence: 99%

Pure squamous cell carcinoma of the gallbladder locally invading the liver and abdominal cavity: A case report and review of the literature

Jin

Zhang

Wei

et al. 2019

WJCC

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BACKGROUNDGallbladder squamous cell carcinoma (GBSCC) is a rare subtype of malignancy and accounts for only 2%-3% of gallbladder malignancies. Due to its rapid development, most patients with GBSCC initially present with an advanced stage of the disease and hence a poor prognosis. The clinicopathological and biological features of SCC remain to be fully elucidated, owing to its uncommon occurrence. The majority of currently available data only described individual case reports or series analyses of trivial cases.CASE SUMMARYA 64-year-old man was admitted for progressively poor abdominal distension and pain. Liver computed tomography (CT) showed infiltration of gallbladder carcinoma into the adjacent liver, and enlarged retroperitoneal lymph nodes. The patient underwent radical cholecystectomy. Part of the mass was grey and soft, and the neoplastic section showed a purulent-necrotic lesion. Hematoxylin and eosin staining revealed a moderately differentiated SCC. Immunohistochemical studies showed strong staining of the tumor for AE1/3 and CK5/6. Staining for CK19, CK7, and CAM5.2 was positive in the cytoplasm. Systemic chemotherapy was not administered because of the patient’s poor physical condition. After five months, CT and magnetic resonance cholangiopancreatography showed multiple metastases in the liver and abdominal cavity.CONCLUSIONSquamous components of GBSCC may explain the complex biological behavior, and CD109 may be involved in the pathogenesis.

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Section: Case Presentationmentioning

confidence: 99%