Immunohistochemical Expression of the Intracellular Component of Galectin-8 in Squamous Cell Metaplasiaof the Bronchial Epitheliumin Neoplastic and Benign Processes

Caulet‐Maugendre, Sylvie; Birolleau, Sophie; Bassen, R.; Desrues, B.; Bidon, Nathalie; Delaval, P.; Ramée, M. P.; Brichory, Franck; Dazord, L.

doi:10.1078/0344-0338-00162

Cited by 13 publications

(9 citation statements)

References 21 publications

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“…The presence of galectin-8 in lung tumor cells and its absence or very low levels in normal lung tissues permits the use of monoclonal antibodies (Po66) for the prevention and treatment of lung cancer. Prior to the knowledge that this antibody was able to specifically bind galectin-8, it was used to detect human lung squamous cell carcinoma by immunoscintigraphy [54,55]. This clinical investigation showed that Po66 antibody was able to detect specifically the lung squamous cell carcinoma recurrence [55].…”

Section: Discussionmentioning

confidence: 99%

Galectins as Cancer Biomarkers

Balan

Nangia‐Makker

Raz

2010

Cancers

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Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved sequence elements of the carbohydrate recognition domain (CRD). Proteins similar to galectins can be found in very primitive animals such as sponges. Each galectin has an individual carbohydrate binding preference and can be found in cytoplasm as well as in the nucleus. They also can be secreted through non-classical pathways and function extra-cellularly. Experimental and clinical data demonstrate a correlation between galectin expression and tumor progression and metastasis, and therefore, galectins have the potential to serve as reliable tumor markers. In this review, we describe the expression and role of galectins in different cancers and their clinical applications for diagnostic use.

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Section: Discussionmentioning

confidence: 99%

Galectins as Cancer Biomarkers

Balan

Nangia‐Makker

Raz

2010

Cancers

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“…Galectin-8 is extensively expressed in normal tissues (brain, breast, large intestine, retina, kidney, pancreas, placenta, spleen, testicle, uterus, blood vessel, esophagus and heart), and it is also distributed in cancer tissues (brain, breast, large intestine, germ cells, head and neck, kidney, muscles, ovary, pancreas, thyroid gland, placenta, prostate, uterus, lung, stomach and esophagus cancer) (3, 27-30). Danguy et al (24) compared the expression of galectin-8 by the type of an organ according to immunohistochemical staining on the cancer tissues that correspond with normal tissues.…”

Section: Discussionmentioning

confidence: 99%

“…An immunohistochemical staining study was previously conducted on the primary and secondary lung cancers of various histologic types (29, 30). Henno et al (29) found that galectin-8 was strongly expressed in squamous cell carcinoma of the lung, but it was weakly expressed in adenocarcinoma and it was not revealed at all in small-cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma

Dong

Kim

Park

et al. 2009

Clin Exp Otorhinolaryngol

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ObjectivesDespite the ongoing development of treatment protocols for laryngeal squamous cell carcinoma (LSCC), the patients suffering with this malady have shown only a modestly improved outcome. This poor outcome has been attributed to the lack of therapy that's individualized to the tumor's biological properties. Various studies have showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues, and the level of the galectin-8 expression may correlate with the malignancy of human squamous cell carcinoma. The purpose of this study is to evaluate the expression of galectin-8 and to investigate its correlations with the primary stage, the nodal involvement, the clinical stage and the histologic grade of squamous cell carcinoma of the larynx.MethodsThe paraffin-embedded tissue specimens from 77 patients who were diagnosed as LSCC between 1993 and 2007 were immunohistochemically stained for galectin-8.ResultsImmunohistochemical analysis showed that a strong positive expression of galectin-8 was correlated with the T-stages, the nodal stages and the clinical stages. However, the histopathologic grades were not correlated with the galectin-8 expression in LSCC.ConclusionThe expression of galectin-8 protein can be used as a prognostic factor for patients with LSCC.

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“…It must be explicitly noted that normal laryngeal tissue was not compared to tumor tissue. More conflicting data appeared when high levels of galectin-8 expression were observed in squamous cell carcinomas of the lung [21,22] . In this case, more aggressive tumor types correlated with an increase in galectin-8 expression as a shift from squamous cell carcinomas to neuroendocrine tumors could be seen.…”

Section: Discussionmentioning

confidence: 99%

Decreased Galectin-8 Is a Strong Marker for Recurrence in Urothelial Carcinoma of the Bladder

et al. 2011

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Objective: To investigate galectin-8 expression patterns in normal urothelium and bladder cancer specimens and to elucidate its prognostic value. Materials and Methods: 162 samples of non-muscle-invasive transitional cell carcinoma, 25 samples of muscle-invasive transitional cell carcinoma and 10 samples of normal urothelium were investigated by immunohistochemistry using tissue microarrays. Complete patient and tumor characteristics were compared with galectin-8 staining patterns. The likelihood of tumor recurrence and progression was analyzed based on a 3-year follow-up. Results: Loss of galectin-8 was associated with the likelihood of tumor recurrence in univariate (p < 0.05) and multivariate analyses (p < 0.01). No significance was observed for tumor progression. Patients whose specimens showed weak galectin-8 expression had a shorter recurrence-free interval (42 vs. 12 months; p < 0.01, log-rank test). All of the 10 normal urothelium samples showed high galectin-8 expression. Decreased staining was found to be associated with higher tumor stages and grades (p < 0.0001, one-way ANOVA). A significant difference was found comparing normal urothelium with any tumor stage (p < 0.01), pTa vs. pT1 tumors (p < 0.05) and non-muscle-invasive vs. muscle-invasive tumors (p < 0.0001). Conclusions: Loss of galectin-8 might be an early step in the development of malignant lesions of the bladder and is a significant independent predictor of recurrence.

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Immunohistochemical Expression of the Intracellular Component of Galectin-8 in Squamous Cell Metaplasiaof the Bronchial Epitheliumin Neoplastic and Benign Processes

Cited by 13 publications

References 21 publications

Galectins as Cancer Biomarkers

Galectins as Cancer Biomarkers

Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma

Decreased Galectin-8 Is a Strong Marker for Recurrence in Urothelial Carcinoma of the Bladder

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