Immunohistochemical Expression of p53, bcl-2, and p21 waf1 in 48 Argentinean Children With Non-Hodgkin Lymphoma

Chabay, Paola; Matteo, Elena De; Preciado, María Victoria

doi:10.1097/01.pai.0000143348.58174.75

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…According to the World Bank statistics, the DRC spends $15 US per capita on health care [45]. In addition, Bcl-2 expression is associated with the expression of the multidrug resistance molecule in NHLs [46,47]. The proportion of bcl-2 expression in our cohort (68.8%) was slightly high than 46% found in Argentina [46].…”

Section: Non-hodgkin Lymphomas and Children mentioning

confidence: 73%

Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

Budiongo

Ngiyulu

Lebwaze

et al. 2015

Pediatric Hematology and Oncology

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Section: Non-hodgkin Lymphomas and Children mentioning

confidence: 73%

Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

Budiongo

Ngiyulu

Lebwaze

et al. 2015

Pediatric Hematology and Oncology

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“…Nevertheless, even though p53-positive immunohistochemical staining does not imply a malignant phenotype, in the 92% of our p53-positive T-cell lymphomas, it could act as an important cofactor in proliferation, since wild-type p53 has been observed in rapidly proliferating cells and in some tumorigenic cell lines [43]. In our population, we have observed a high frequency of p53 overexpression in a pediatric NHL series including both T-and B-cell lymphomas [44]. The observed p53 expression is higher than that reported by several Asiatic groups, but it should be taken into account that the histological characteristics of T lymphomas of our series are different [8,22].…”

Section: Discussionmentioning

confidence: 99%

Low Frequency of Epstein Barr Virus Association and High Frequency of p53 Overexpression in an Argentinean Pediatric T-Cell Lymphoma Series

et al. 2009

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T-cell non-Hodgkin's lymphomas (NHLs) represent 10% to 15% of all diagnosed lymphomas in Western countries. Various geographic frequencies of T-cell NHL have been documented, in part reflecting increased exposure to pathogenic factors such as Epstein-Barr virus (EBV). Our aims were to assess EBV and p53 expression in Argentine pediatric T-cell lymphoma and to correlate them with patients' survival. Epstein-Barr encoded RNAs (EBERs) in situ hybridization and LMP1 and p53 immunohistochemical staining were performed on formalin-fixed paraffin-embedded lymph node biopsies from 25 pediatric T-lymphoma patients. In 17 of 25 samples good-quality DNA was obtained, and EBER polymerase chain reaction was assessed to confirm in situ hybridization and immunohistochemical results. Epstein-Barr virus expression was found in 8.0% of cases. p53-positive staining was distributed in 92% of pediatric cases. Kaplan-Meier survival analysis showed that neither EBV nor p53 expression was statistically significantly associated with event-free survival. Our data showed a low frequency of EBV association with pediatric T-cell lymphoma. It seems that p53 plays an important role in proliferation in our studied population, since it is overexpressed in 92% of T-cell lymphoma cases.

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No Influence of bcl-2, p53, and p21 waf1 Protein Expression on the Outcome of Pediatric Hodgkin Lymphomas

Chabay¹,

Pesce²,

Matteo

et al. 2006

Journal of Pediatric Hematology/Oncology

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In Argentina, lymphomas account for 13.6% of all pediatric tumors and 47% of them are Hodgkin lymphoma. Previous studies of lymphoma series have reported the expression of apoptotic and cell cycle proteins. Our aim was to study these markers in our pediatric patients and correlate them with their outcome. Immunohistochemical staining with monoclonal antibodies anti-p53, bcl-2, p21, and mdm2 were performed on formalin-fixed paraffin-embedded Hodgkin lymphoma lymph node biopsies from 54 pediatric patients. The analyzed oncogenes p53, bcl-2, p21, and mdm2 exhibited 81%, 44%, 76%, and 90% positive staining, respectively. The most prevalent p53/p21 expression pattern was p53+/p21+, in 57% of cases, whereas concerning p53/mdm2 expression pattern p53+/mdm2+ was observed in 61% of cases. We failed to find any statistically significant correlation between oncogene expression and patient's survival. It seems that p53 plays an important role in lymphomagenesis in our studied population, because it is overexpressed in 81% of Hodgkin lymphoma cases and in more than 50% of cases, it might be able to activate its cellular effectors. Bcl-2 staining observed in 44% of our cases could represent a failure in bcl-2 down-regulation that leads to a rescue event in defective germinal center B-cells, that allows them to develop into Reed-Sternberg and Hodgkin cells.

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Immunohistochemical Expression of p53, bcl-2, and p21 waf1 in 48 Argentinean Children With Non-Hodgkin Lymphoma

Abstract: Of 81% of cases with p53 overexpression, 46% exhibited a nonfunctional p53 pattern, and this may contribute to dysregulation of proliferation, bcl-2 expression in up to 46% of cases may reflect a failure of bcl-2 downregulation in pre-B and immature B cells.

Cited by 4 publications

References 31 publications

Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

Low Frequency of Epstein Barr Virus Association and High Frequency of p53 Overexpression in an Argentinean Pediatric T-Cell Lymphoma Series

No Influence of bcl-2, p53, and p21 waf1 Protein Expression on the Outcome of Pediatric Hodgkin Lymphomas

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