Immunohistochemical expression of nm23 in primary invasive malignant melanoma is predictive of survival outcome

Reticulin and NM23 Staining in the Interpretation of Lymph Nodal Nevus Rests

“…19,[21][22][23][24] Thus, although we were unable to generate meaningful results, this study should not discount its potential usefulness, especially with other neoplasms as well. Although we could not obtain any consistent staining with our particular NM23 clone, others may yield better results.…”

“…Consequently, various studies have addressed this challenging situation. 19,[21][22][23] However, other studies have not shown such an inverse relationship with varying prognostic factors such as ulceration and tumor thickness. However, adjunct methods are extremely desirable and at times necessary.…”

“…By morphology, hematoxylin and eosin (H&E) examination and comparison with a patient's known primary melanoma when applicable is often sufficient for a definitive diagnosis. 22,23 This study sought to evaluate the differential diagnostic utility of these markers in lymph node nevus rests and MM metastatic to lymph nodes. Such methods have included numerous immunohistochemical stains such as HMB-45, 5,6 Ki-67 proliferation rate, 5,10 p16, 11 IMP-3 (insulin-like growth factor-II messenger RNAbinding protein-3), 12 and most recently fluorescence in situ hybridization (FISH).…”

Ο ρόλος των ογκοπρωτεϊνών p53 και bcl - 2 στο μελάνωμα του δέρματος

“…165 Πρόσφατα εδείχθη η προγνωστική αξία της ανοσοiστοχημικής έκφρασης του γονιδίου nm23 στο μελάνωμα. 166 Εν τούτοις, οι αναφερόμενες στην βιβλιογραφία απώλειες γονιδιακού υλικού του χρωματοσώματος 17 στο μελάνωμα έχουν σποραδικό χαρακτήρα 167,168 και δεν φαίνεται οτι παίζουν σημαντικό ρόλο στην ογκογένεση του μελανώματος. 169 Aπώλεια της έκφρασης του ογκοκατασταλτικού γονιδίου c-kit 170 και αυξημένη έκφραση του γονιδίου c-met έχουν αναφερθεί σε προχωρημένα στάδια εξέλιξης του μελανώματος.…”