Immunohistochemical Expression of “HCG-β” in Colorectal Carcinoma

Bassam, Amira M.; Raafat, Yousra; Al-Aziz, Ahmed Mahmoud Abd; Mostafa, Rasha Ramadan

doi:10.3889/oamjms.2021.6854

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…This was in a line with Ko and Pyo, 2019 and Rezaee et al, 2021 who noted presence of perineural invasion in about 16.7% and 20.1 of their cases respectively [23.17] . On the other hand, Bassam et al, 2021 reported presence of perineural invasion in 41 % of cases [24] .…”

Section: Resultsmentioning

confidence: 97%

Immunohistochemical Expression of CD44 in colorectal carcinoma

Kasem,

abdel meguid,

Mohamed Tawfik

et al. 2023

Minia Journal of Medical Research

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Background: Rectal cancer ranks eighth overall whereas colon cancer is the fourth most prevalent cancer worldwide. Incidence instances of colorectal cancer (CRC) were projected to reach 1.9 million in 2020, with 0.9 million deaths. Due to westernization, CRC is becoming more common in middle-and low-income countries, where it is more prevalent in developed nations. Colon cancer is the ninth most frequent cancer in Egypt and according to WHO figures, it accounts for 2.7% of all cancer cases and 2.4% of all cancer-related fatalities. Rectal cancer is the seventeenth most common cancer, accounting for 1.2% of all cancer cases and 0.98% of all cancer-related deaths. In Egypt, CRC is the sixth most prevalent cancer overall. Colorectal cancer spreads and relapses due in large part to stem cells (CSCs). A variety of cell surface markers, including CD44, which is a cell-surface trans-membrane glycoprotein and has been shown to activate several tumour biological behaviours including proliferation, differentiation, invasion, and motility, are used to identify colorectal CSCs. Aim of the work: the present study was conducted to study the relationship between CD44 expression and the clinicopathological characteristics of CRC. Material and Methods: 140 randomly chosen tissue blocks from primary colorectal adenocarcinomas and their lymph nodes were immunohistochemically stained for CD44. Of these, 53 (75.7%) cases were conventional adenocarcinomas (NOS), 7 (10%) were mucinous carcinomas, and 10 (14.3%) were Signet ring carcinomas. Institutional Review Board" IRB", Minya University has reviewed & approved submitted research proposal" Approval No. 45:6/2021. Results: CD44 high expression was detected in 86 (61.4%) of cases. A statistically significant association was detected between high CD44 expression and tumor size, tumor grade, poorly differentiated clusters (PDCs) grade, lymph node involvement, Lympho-vascular invasion (LVI) advanced tumor stage, tumor necrosis and tumor infiltrating lymphocytes (P value 0.005 * , <0.001 * , <0.001 * , <0.001 * , <0.001*, <0.001 * , <0.011 and <0.001*). The association between CD44 high expression and different clinicopathological variables were further tested using univariate and multivariate regression analysis. This study detected that tumor grade, lympho-vascular invasion, modified Dukes staging and PDCs grade were independently associated with CD44expression (P value 0.008*, 0.009*, 0.007*, 0.001* respectively). Conclusion: CD44 high expression could be considered as poor prognostic marker in the evaluation of patients with Colorectal Carcinoma. CD44 can play an essential role in the pathogenesis, aggressiveness, invasion, and progression of CRC.

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Section: Resultsmentioning

confidence: 97%