Immunohistochemical expression of Fascin-1 in colorectal cancer in relation to clinical and pathological parameters

Abstract

Introduction. Fascins are a group of proteins taking part in the maintenance of a proper structure of the cellular cytoskeleton. Fascin-1 is an actin-bundling protein present in neurons, fibroblasts, endothelial, smooth muscle, dendritic and mesenchymal cells whereas lack of its expression is characteristic of epithelial cells. Fascin-1 overexpression can be observed in neoplastic cells. Therefore, the aim of this study was to assess the expression of Fascin-1 protein in patients with colorectal cancer (CRC) and to analyze associations between Fascin-1 expression and clinical-pathological parameters. Material and methods. The study material included postoperative samples (tumor and unchanged colon tissue) obtained from 51 CRC patients. Fascin-1 expression was assessed in the paraffin sections by immunohistochemistry. Results. A statistically significant correlation was found between the histological type of cancer and the expression of Fascin-1 (p = 0.012). Increased expression of Fascin-1 in CRC was more frequent in adenocarcinoma type without the mucosal component with a better prognosis and decreased expression of this protein correlated with infiltration of cancer cells to blood and lymphatic vessels (p = 0.038). Conclusions. Our findings indicate a potential role of Fascin-1 in the pathogenesis of colon cancer; however, further studies will show whether this protein plays a role in the infiltration of colorectal cancer cells.

Emerging Role of Fascin-1 in the Pathogenesis, Diagnosis, and Treatment of the Gastrointestinal Cancers

“…The presence of fascin-1 in the secondary tumor metastasis was not recorded [ 30 ]. Mucinous differentiation of tumor and its classification into the histological subtypes was also related to the fascin-1 expression [ 33 , 35 ]. In addition, Roseweir and colleagues noted that the increased expression levels of the EMT markers and fascin-1 were associated with tumor budding, higher systemic inflammation, and fewer memory T-cells [ 36 ].…”

Fascin-1 and Its Role As a Serological Marker in Prostate Cancer: a Prospective case–control Study

“…Elevated expression of FSCN1 in colorectal and gallbladder cancer is an independent negative survival outcome factor, which correlates with an increased risk for disease recurrence and poor prognosis [25][26][27][28][29]. Similarly, high expression of FSCN1 has been identified in patients with increased risk for recurrence in breast and non-small-cell lung cancer [30][31][32][33].…”

Plasma Levels and Tissue Expression of Selected Cytokines, Metalloproteinases and Tissue Inhibitors in Patients With Cervical Cancer

“…The clinical stage and histological classification were determined following the International Federation of Gynecology and Obstetrics (FIGO) criteria in all cases (31). Written consent including participants' statements regarding their medical history and lifestyle habits were obtained from all as previously stated (32). None of the patients had received chemo-or radiotherapy before sample collection.…”