Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression

Ioachim, Elli; Charchanti, Antonia; Briasoulis, Evangelos; Karavasilis, Vasilios; Tsanou, H; Arvanitis, Dimitrios L.; Agnantis, Niki J.; Pavlidis, Nicholas

doi:10.1016/s0959-8049(02)00210-1

Cited by 265 publications

(244 citation statements)

References 23 publications

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“…Recent studies have shown that the ECM does not only act passively as a support for cells, but also provides information to these cells modifying their behavior, an event that might be responsible for tumorigenesis [16][17][18][19][20]. Among the ECM components, some proteins are important due to their regulatory or structural functions.…”

Section: Discussionmentioning

confidence: 99%

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Medeiros

Nonaka

Galvão

et al. 2009

Eur Arch Otorhinolaryngol

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This study evaluated the expression of Wbronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the diVerences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate Wbronectin expression in the stroma. Solid ameloblastomas showed intense expression of Wbronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of Wbronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.

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Section: Discussionmentioning

confidence: 99%

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Medeiros

Nonaka

Galvão

et al. 2009

Eur Arch Otorhinolaryngol

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“…The diverse microarchitectures of fibrillar collagen and the range of resulting biomechanics can result in very different microenvironments despite equivalent levels of collagen [83][84][85], which potentially explains the weak clinical link between collagen I and prognosis in older studies [86,87]. It remains difficult to decouple the effects of fiber diameter, pore size and biomechanics, but it appears that all three act on cells (reviewed in [88]).…”

Section: Microstructure Biomechanics and Crosslinkingmentioning

confidence: 99%

The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking

Robertson

2016

Experimental Cell Research

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The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking a b s t r a c tThe extracellular matrix in the healthy breast has an important tumor suppressive role, whereas the abnormal ECM in tumors can promote aggressiveness, and has been linked to breast cancer relapse, survival and resistance to chemotherapy. This review article gives an overview of the elements of the ECM which have been linked to prognosis of breast cancers, including changes in ECM protein composition, splicing, and microstructure. Published by Elsevier Inc.

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“…COL5A1 (collagen type VI) is a collagen family protein that is involved with ECM formation (46). Overexpression of collagen type IV is found to be positively correlated with tumor size in breast cancer (47). Based on our results, we deduce that miR-506 may play crucial roles in the promotion of HNSCC metastasis by regulating COL5A1 via the ECM receptor interaction pathway.…”

Section: Discussionmentioning

confidence: 55%

Subpath analysis of each subtype of head and neck cancer based on the regulatory relationship between miRNAs and biological pathways

Zhang²,

Xia

et al. 2015

Oncology Reports

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Abstract. The aim of the present study was to explore the potential mechanisms involved in each subtype of head and neck squamous cell carcinoma (HNSCC) via subpath analysis and to investigate their relevance in the prevention of HNSCC. Gene expression profiles of GSE6631 and GSE39366 containing 44 and 168 HNSCC samples, respectively, were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) from samples in GSE6631 and GSE393666 were screened using the Detection of Imbalanced Differential Signal (DIDS) method respectively. DEGs in GSE39366 were matched with the DEGs in GSE6631 and were used to classify the subtypes of HNSCC based on hierarchical clustering analysis. Furthermore, DEGs were separated into different subtypes and then the pathway information was analyzed. The regulated miRNAs for the DEGs in each subtype were analyzed to select the significant subpaths. Totally, 1,095 DEGs from GSE6631 and 2,528 DEGs from GSE39366 were screened. Samples in GSE39366 were separated into four subtypes. Specific genes in each subtype and DEGs in the common gene set involved in a variety of pathways were identified. In addition, the significant miRNAtarget-pathway subpath of each subtype of HNSCC and the common gene set of HNSCC were also enriched. Our data suggest that human papillomavirus (HPV) is positively correlated with HNSCC in subtype 2. Several miRNAs (miRLet-7A, miR-1, miR-206, miR-153, miR-519A and miR-506) and their target genes (CYP46A1, BPNT1, MCM7 and COL5A1) are crucial for HNSCC prevention via different pathways and may provide further knowledge of the mechanisms involved in the progression of HNSCC.

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Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression

Cited by 265 publications

References 23 publications

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking

Subpath analysis of each subtype of head and neck cancer based on the regulatory relationship between miRNAs and biological pathways

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