Immunohistochemical expression of EGFR in colorectal adenocarcinoma and its correlation with the presence of lymph node metastases

Kapogiannatos, G.; Margaritis, Dimitrios; Alevizou, R.; Gogoulou, Ioanna; Nomicos, A.; Digalakis, M.

doi:10.1007/s13126-015-0242-1

Cited by 3 publications

(1 citation statement)

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“…Concerning the N stage in the current study, no relation was observed between EGFR expression and lymph node metastasis. Kapogiannatos et al 25 found a significant relationship. The current study agreed with Azevedo et al 22 , who observed higher expression of EGFR in CRC compared to adenoma tissue.…”

Section: Discussionmentioning

confidence: 91%

Clinicopathological value of epidermal growth factor receptor (EGFR) and Ki-67 expression in colorectal adenoma and adenocarcinoma

Eman Mohamed Ahmed Nor,

Eman Mohamed Saied,

Samir Nemr Mina

et al. 2023

J Pak Med Assoc

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Objective: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma and carcinoma cases, and to relate their expression with the available clinicopathological data.Methods: The retrospective study was conducted at the Faculty of Medicine, Kafrelsheikh University, Egypt, from September 2019 to October 2020, and comprised formalin-fixed and paraffin-embedded specimens related to cases of colorectal adenoma and those of colorectal carcinoma, who had no previous radiation or chemotherapeutic treatment. Immunohistochemical staining of all thecases was done using anti-epidermal growth factor receptor and anti-Ki-67 antibodies. Data was analysed using SPSS 20.Results: Of the 70 cases, 20(28.5%) were of colorectal adenoma; mean age 52.95±13.47 years, and male-to-female ratio 1:1. The remaining 50(71.5%) cases had colorectal carcinoma; mean age 51.08±13.49 years, and male-to-female ratio 1.17:1. Epidermal growth factor receptor and Ki-67 overexpression related significantly to villous histopathological type and high-grade dysplasia in colorectal adenoma cases (p<0.05). In colorectal carcinoma cases, epidermal growthfactor receptor overexpression related significantly to tumour grade (p<0.05). Ki-67 overexpression related significantly to increased pathological stage (p<0.05).Conclusions: Overexpression of epidermal growth factor receptor and Ki-67 was found to be an ominous sign of colorectal adenoma aggressiveness, and the risk of progression to colorectal carcinoma.Keywords: Antigen, Adenoma, Colorectal neoplasms, Receptors, Carcinoma.

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Section: Discussionmentioning

confidence: 91%