Immunohistochemical expression of cornulin in lesional and perilesional skin of plaque psoriasis

Abstract

Psoriasis is a common chronic immunity-related inflammatory disease of joints and skin with vague pathogenesis. It is a mixed T helper 1 (Th1)/Th17 cell-mediated disorder. 1 In habitats of western areas, psoriasis prevalence is within 2%-3%. 2 On the other hand, it ranges from 0.19% to 3% in Egyptians. 3 An increased rate of keratinocytes proliferation, accompanied by the formation of erythematous plaques covered by silvery scales, is among the most common features in psoriasis together besides dermal inflammatory infiltrate and capillary dilatation. 4 Several etiologies included in the pathogenesis of psoriasis are generally intersecting and potentiating each other as genetic aberrations, environmental elicits, and abnormal immune mechanisms. 5

Cornulin (CRNN) Contributes to the Development of Cutaneous squamous cell carcinoma via Activation of AKT in SCL-1

“…CRNN is localized in the cytoplasm and perinuclear region [10,11] . In addition to esophageal cells, CRNN overexpression has also been identi ed in other squamous cells, including oral squamous cells, cervical squamous cells, foreskin squamous cells, skin squamous epithelium, meibomian gland epithelial cells, and thyroid follicular cells [10,[12][13][14][15][16][17][18][19][20][21][22] . Apart from eczema [14] , CRNN has been reported to be downregulated in cancer tissues, including squamous cell carcinomas such as esophageal squamous cell carcinoma, oral squamous cell carcinoma, cervical squamous cell carcinoma, head and neck squamous cell carcinoma, and thyroid cancer [11,13,15,17,19,[22][23][24][25] .…”