Immunohistochemical evaluation for hormone receptors in Breast Cancer: A practically useful evaluation system and handling protocol

Abstract

This article reviews the current status of hormone receptor evaluation in and out of Japan, and introduces the proposed working protocol of the task force for Adequate immunohistochemical evaluation in routine practice for breast cancer by the Japanese Breast Cancer Society. Understanding the principles and the developmental process of immunohistochemistry helps us to utilize a scoring system adequately. Methodologies of hormone receptor examination and immunohistochemical procedures are briefly introduced. Each scoring system is based on different principles. The proposed working protocol takes into account the reproducibility of results among observers, institutions and staining procedures, which is justified based on the current situation in Japan. Future directions for the standardization of immunohistochemical hormone receptor evaluation are also described.

Anti-3-18F-FACBC (18F-Fluciclovine) PET/CT of Breast Cancer: An Exploratory Study

“…Mammography, ultrasound, and MRI form the backbone of breast imaging (3)(4)(5)(6). 18 F-FDG PET has also assumed an important role in wholebody staging, recurrent disease detection, and therapy response monitoring (7). Molecular breast imaging with 18 F-FDG positron emission mammography and 99m Tc-sestamibi are also being explored (3,8,9).…”

Histopathological Grade versus Estrogen and Progestron Receptor Status in Carcinoma Breast- A Single Center Study

“…A simplified Allred score groups 0and 2; 3 and 4; 5 and 6; and 7 and 8 for 4 possible values. [7] Proportion score (PS) The most frequent tumor grade was grade I (49%) followed by grade III (40%) and grade II (11%) ( Table 3). The result of the study showed 45.16% cases were ER+/PR+, 4.84% cases ER+/PR-, 6.45% ER-/PR+ and 43.55% cases were ER-/PR-( Table 4,5,6) .…”

Comparison of evaluations of hormone receptors in breast carcinoma by image-analysis using three automated immunohistochemical stainings

“…the site for evaluation was not limited to the invasive area, but incorporated the entire lesion. two scoring systems were used to evaluate the IHC findings, the Allred score (21) and J-score (2,3,22). the J-score comprises proportional values irrespective of the intensity of stained nuclei, and the proportion of cells stained in each specimen was recorded as 0, none; 1, <1%; 2, 1-10%; 3, ≥10%, as advocated and employed as the cut-off points in previous reports (23,24).…”