Immunohistochemical Differences in Squamous Precancerous and Cancerous Lesions of the Oral Cavity and the Larynx: Preliminary Data

Abstract

The aim of this study is to assess immune cell populations in squamous precancerous (preinvasive) and cancerous lesions of the oral cavity and larynx. Qualitative and quantitative immunohistochemical analyses were performed to determine the expressions of CD4, CD8, CD15, CD57 and CD68. The expressions of programmed death-ligand 1 (PD-L1), p16 and Ki67 were also assessed. Squamous cell lesions from forty-one patients were included in the study. Sixteen samples were categorized as precancerous (preinvasive) lesions and twenty-five as invasive squamous cell carcinoma. Invasive lesions showed a negative correlation with CD57+ cells (ρ = −0.69) and a positive correlation with Ki67 (ρ = 0.61). The amount of CD4+ lymphocytes was higher in invasive lesions. There were no differences in PD-L1 and p16 immunoreactivity. Our analysis showed differences in the immunohistochemical profile between preinvasive and invasive squamous cell lesions. In the near future, this study should be useful in driving treatment strategy in both preinvasive and invasive squamous cell lesions of the oral cavity and larynx. However, studies on larger series of patients focusing on site-specific lesions are required.

Diagnostic Value of Spiral CT and Magnetic Resonance Imaging Scanning in Gastric Cancer and Precancerous Lesions

“…Gopi et al analyzed the MRI findings of 9 palatal tumors and found that MRI had significant advantages in assessing structures surrounding malignant tumor infiltration [ 10 ]. Aló et al summarized the typical CT and MRI imaging findings of different histological types of palatal tumors and tumor-like lesions and found that conventional MRI signs can help narrow the range of differential diagnosis [ 11 ]. Cesare et al studied the apparent diffusion coefficient (ADC) value of 32 salivary gland tumors (17 benign and 15 malignant) examined by preoperative diffusion-weighted imaging (DWI), they found that the ADC value could not reliably distinguish benign and malignant salivary gland tumors, and they speculated that the possible reason was that some salivary gland malignancies such as acinar cell carcinoma contained rich extracellular matrix, which led to the increase of the corresponding ADC value [ 12 ].…”

Preparation and Synergistic Anti-Tumor Effect of Iridium Oxide Nanocomposites under Microscope

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Immunohistochemical expression of PDL1 in laryngeal carcinoma in relation to P53 and ki67 proliferative index

“…This is a vital and important point in checking and screening all premalignant lesions as the possibility and risk of malignant changes is high, and this is agreed with other study obtained by. Aló, P. L. et al 2021 that documented PDL1 expression in premalignant lesions was less frequent as malignant lesion (12).…”