Immunohistochemical detection of transforming growth factor‐α, epidermal growth factor, and vascular endothelial growth factor expression in hyperstimulated rat ovary

Özçakır, Hasan Tayfun; Giray, Seren Gülşen; Özbilgin, Mahmut Kemal; Uyar, Yýldýz; Laçin, Selman; Çağlar, Hüsnü

doi:10.1111/j.0001-6349.2005.00586.x

Cited by 10 publications

(7 citation statements)

References 33 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regulation of the VEGF system seems to be important for controlling ovarian hyperstimulation (29). Previously, enhanced expression of VEGF proteins in the stroma, endothelium, and granulosa cells has been shown in hyperstimulated ovaries (30). In vitro, VEGF expression was confirmed in human granulosa cells and could be induced in response to administration of hCG (14,31).…”

Section: Discussionmentioning

confidence: 96%

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

Wei¹,

Chou²,

Chen³

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

Wei¹,

Chou²,

Chen³

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

“…In vitro studies confirmed that TGF-α, which was localized and expressed at ovarian follicles and stroma interval, has a regulatory role on ovarian tissue during entire procedure of growth, degeneration, and atresia of follicular. [ 27 , 28 ] TGF-α was highly expressed in oocytes during primordial follicles stage, then the expression of TGF-α gradually decreases along with maturation of follicles, which implies that TGF-α synthesized in early stage of follicle formation might participates in development of primordial follicles and early growth of oocytes. [ 29 , 30 ] Thalidomide not only plays an immune-inhibitory role for TNF-α, interleukin 6 (IL-6), and interleukin 8 (IL-8) but also an inhibitory role for TGF-α and TGF-β.…”

Section: Discussionmentioning

confidence: 99%

Thalidomide results in diminished ovarian reserve in reproductive age female IBD patients

Xiang

Mao

Wei³

et al. 2017

Medicine

View full text Add to dashboard Cite

The effectiveness of thalidomide in treating inflammatory bowel disease (IBD) has been widely recognized. Meanwhile, many serious adverse drug reactions have been observed, but no know reports on ovarian reserve function.Female patients, ranging in age between 18 and 40, were referred to our institution to undergo sex hormone detection and ultrasonic scanning for ovarian function assessment, between February 1, 2016 and September 31, 2016.Thirty-three patients treated with thalidomide (group A), 73 patients without thalidomide (group B), and 78 healthy women as control were studied. Menstrual disorder was higher in group A than group B (78.8% vs 57.2%, P < 0.05), and both groups were higher than control group 33.3%, P < 0.05. Anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) in group A were lower than group B, P < 0.05, while estradiol (E2) and follicle-stimulating hormone (FSH) levels were no different between 2 groups. Crohn Disease Endoscopic Index of Severity (CDEIS) and thalidomide were the independent risk factors in diminished ovarian reserve (DOR), and when dose reached 75 mg/day, 5 g total, or when treatment time reached 10 months respectively. These influence may increasing (P < 0.05), but they may recover after stopping (P < 0.05).Thalidomide was an independent risk factor leading to DOR in female IBD patients, the influence may increasing when daily dose and accumulated dose reached 75 mg/day and 5 g total dose, but may be reversed by stopping.

show abstract

“…In addition to NO-induced vasodilation, there is VEGFinduced angiogenesis in the preovulatory follicle in the hours preceding ovulation (26). Granulosa cells do produce VEGF (27), and VEGF from follicular fluid and granulosa cells induces vessel growth in the ovary (28).…”

Section: Discussionmentioning

confidence: 99%

Ovarian wedge resection restores fertility in estrogen receptor β knockout (ERβ ^−/− ) mice

Inzunza

Morani²,

Cheng³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Ovulation rarely occurs in mice in which the estrogen receptor ␤ (ER␤) gene has been inactivated (ER␤ ؊/؊ mice). Here, we investigated whether this subfertility is due to a defect in the ovary itself or to more general endocrine changes in ER␤ ؊/؊ mice. We transplanted ER␤ ؊/؊ ovaries into WT mice and WT ovaries into ER␤ ؊/؊ mice. Upon mating with ER␤ ؊/؊ males, fertility increased from 20% in control intact ER␤ ؊/؊ group to 40% in the WT recipients with ER␤ ؊/؊ ovaries. The transplantation procedure was not efficient, and when WT ovaries were transplanted into WT mice, fertility was only 36%. Surgical ovarian wedge resection, a procedure which induces ovulation in anovulatory women with polycystic ovarian syndrome, resulted in 100% fertility of ER␤ ؊/؊ mice. In ER␤ ؊/؊ mice, as the follicles enlarged, the thecal layer remained very compact (revealed by H&E and collagen staining), and there was no increase in vascularization (measured as smooth muscle actin). In addition, there was an increase in PDGF receptor ␣ (PDGFR␣) and a decrease in PDGF␤ expression in the granulosa cells, similar to what has been found in follitropin receptor knockout mice. After wedge resection, expression of both smooth muscle actin and PDGFRs was normalized. During normal follicular development, increased vascularization of the thecal layer is a prerequisite for further follicular growth. We suggest that the defect in ER␤ ؊/؊ mouse ovaries is a failure of communication between the granulosa and thecal layers. The follicles do not mature because of insufficient blood supply. This problem is overcome by stimulating neovascularization by simple wedge resection of the ovaries. estrogen receptor ͉ follitropin or follicle-stimulating hormone ͉ thecal ͉ granulosa ͉ neovascularization

show abstract

Immunohistochemical detection of transforming growth factor‐α, epidermal growth factor, and vascular endothelial growth factor expression in hyperstimulated rat ovary

Abstract: TGF-alpha, EGF, and VEGF are found to have increased in the hyperstimulated ovaries and this finding seems to be involved in the OHSS pathogenesis.

Cited by 10 publications

References 33 publications

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

Thalidomide results in diminished ovarian reserve in reproductive age female IBD patients

Ovarian wedge resection restores fertility in estrogen receptor β knockout (ERβ ^−/− ) mice

Contact Info

Product

Resources

About

Immunohistochemical detection of transforming growth factor‐α, epidermal growth factor, and vascular endothelial growth factor expression in hyperstimulated rat ovary

Abstract: TGF-alpha, EGF, and VEGF are found to have increased in the hyperstimulated ovaries and this finding seems to be involved in the OHSS pathogenesis.

Cited by 10 publications

References 33 publications

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

Thalidomide results in diminished ovarian reserve in reproductive age female IBD patients

Ovarian wedge resection restores fertility in estrogen receptor β knockout (ERβ −/− ) mice

Contact Info

Product

Resources

About

Ovarian wedge resection restores fertility in estrogen receptor β knockout (ERβ ^−/− ) mice