Immunohistochemical detection of Proliferating cell nuclear antigen (PCNA) in 23 cases of ameloblastoma

Funaoka, K.; Arisue, Makoto; Kobayashi, Ichiro; Iizuka, Tadashi; Kohgo, Takao; Amemiya, Akira; Totsuka, Yasunori

doi:10.1016/0964-1955(96)00007-3

Cited by 28 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a number of papers reporting the immunohistochemical expression of intermediate filaments, 15 growth factors, 16 basement membrane components, 17 cell cycle regulating factors 18 –21 and apoptotic proteins 22 , 23 in ameloblastomas but calcium‐binding proteins have not been investigated in these tumours.…”

Section: Discussionmentioning

confidence: 99%

Calretinin expression in ameloblastomas

Altini

Coleman

Doglioni³

et al. 2000

Histopathology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Calretinin expression in ameloblastomas

Altini

Coleman

Doglioni³

et al. 2000

Histopathology

View full text Add to dashboard Cite

show abstract

“…Funaoka et al [2], Ong'uti et al [19] and Sandra et al [22] have reported that labeling indices of PCNA and Ki-67 antigen were higher in the follicular compared with the plexiform type. By contrast, Kim and Yook [8] and Piattelli et al [20] reported contrary findings.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Analysis of Cell Proliferation and Suppression of Ameloblastoma with Special Reference to Plexiform and Follicular Ameloblastoma

Hirayama

Hamada

Hasui

et al. 2004

Acta Histochem. Cytochem.

View full text Add to dashboard Cite

To understand proliferation and suppression in ameloblastoma that exhibit locally invasive growth and recur clinically, the expression of proliferating cell nuclear antigen (PCNA), Ki-67 antigen, topoisomerase IIa, p53 and p21 proteins were analyzed with immunohistochemistry. Sections of archival ameloblastoma tissues were used (16 plexiform and 14 follicular types). Each antigen was labeled by the polymer method with optimal antigen retrieval. The plexiform type exhibited higher expression of PCNA, Ki-67 and topoisomerase IIa antigens than the follicular type. Expression of PCNA correlated significantly with that of the Ki-67 antigen. The plexiform type also exhibited greater expression of p53 and p21 proteins than the follicular type. Expression of p53 protein correlated significantly with that of p21, PCNA, Ki-67 antigen and topoisomerase IIa. Expression of p21 protein did not correlate with that of the proliferation-related antigens. These findings suggest that the plexiform ameloblastoma has higher proliferating activity and malignant potentiality as neoplastic cells than the follicular ameloblastoma.

show abstract

“…Most investigations have focused on the characteristics of the epithelial component that constitutes the tumor parenchyma [6][7][8][9] while few studies have analyzed the properties of the extracellular matrix (ECM), which constitutes the tumor stroma [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Medeiros

Nonaka

Galvão

et al. 2009

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

This study evaluated the expression of Wbronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the diVerences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate Wbronectin expression in the stroma. Solid ameloblastomas showed intense expression of Wbronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of Wbronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.

show abstract

Immunohistochemical detection of Proliferating cell nuclear antigen (PCNA) in 23 cases of ameloblastoma

Cited by 28 publications

References 16 publications

Calretinin expression in ameloblastomas

Calretinin expression in ameloblastomas

Immunohistochemical Analysis of Cell Proliferation and Suppression of Ameloblastoma with Special Reference to Plexiform and Follicular Ameloblastoma

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Contact Info

Product

Resources

About