Immunohistochemical detection of p53 protein in neoplastic, preneoplastic and normal bronchial mucosa specimens obtained during diagnostic bronchoscopy.

Polyploidization and centrosome hyperamplification in inflammatory bronchi

“…Especially when considering, that other investigators could show that changes in the p53 pathway generating a malfunction of wt-p53 thus may be responsible for the development of poly-and aneuploidy in the lung [38,39,40]. Though, up to now, dysplasia is discribed as the earliest stage of known p53 mutations, our findings indicate an earlier involvement of mutated or at least non-functional p53 [41,42]. Moreover, loss of p53 function is discussed as a link between inflammation and cancer, according to the fact that p53 can be functionally inactivated by a proinflammatory cytokine release [43].…”

Prognostic value of p53 and Ki67 expression in fiberoptic bronchial biopsies of patients with non small cell lung cancer

“…Furthermore, utilizing these small biopsy lung specimens we compared p53 and Ki67 positivity with survival rate. There are few studies describing p53 overexpression in samples obtained in a non surgical setting and it relationship to survival rate [7][8][9][10][22][23][24]. Murakami and coll.…”

“…Since a first study demonstrated the relevance of p53 immunohistochemical expression in lung cancer [4], several reports have been carried out on the clinical and prognostic significance of p53 alteration in this field, but the results are not always of univocal interpretation, with a few meta-analyses inclining towards abnormal p53 status being associated with poorer prognosis [5,6]. Actually, there are many publications in which p53 overexpression, in small biopsies, obtained by bronchoscopy or transbronchial biopsies, burdens for poor prognosis in advanced non-small cell lung cancer [7][8][9][10].…”