Immunohistochemical detection of carcinoembryonic antigen (CEA) in parotid gland carcinomas

Abstract

The presence of CEA in parotid gland tumours was studied by immunohistochemical methods. 52 cases were analysed. 7 of 8 adenocarcinomas, 3 of 5 cystadenocarcinomas, 3 of 4 adenoid cystic carcinomas and all 3 salivary duct carcinomas were positive for CEA. 5 of 8 squamous cell carcinomas and 9 of 21 carcinomas in a pleomorphic adenoma were also positive for CEA. The anaplastic carcinomas were negative. The distribution pattern of the presence of CEA in the carcinomatous and the adjacent normal or inflamed tissue was analysed. The results are discussed with regard to their histogenetic and diagnostic implications.

Immunohistochemical expression of monoclonal antibody against epithelial membrane antigen in salivary gland tumors.

“…In obstructive lesions of submandibular glands, EMA distribution is able to serve as a functional marker of both acinar and ductal cells (23). While Gusterson et al (7) failed to detect EMA in the serous acinar cells, and such a staining pattern is quite similar to that of carcinoembryonic antigen (CEA) in serous acinar cells (1,2,26,27). These differences suggest the determinant recognized by monoclonal antibody to human EMA used may have a widely characteristic cross reactivity due to certain glycoprotein or a part of sugar residues.…”

Immunopathology of Phenotypic Change on Human Parotid Gland Adenocarcinoma

“…It has been known that several proteins or glycoproteins are secreted by the major salivary glands; these include amy lase. lactoferrin, secretory component, lysozyme and CEA [22][23][24][25]. The results are summarized in table 2.…”

Elevated carcinoembryonic antigen levels correlating with disease recurrence in a patient with adenoid cystic carcinoma

“…With regard to benign and malignant salivary neoplasms, CEA staining has been observed in a wide variety of tumors, mainly in association with the formation of well formed ducts. 23,[25][26][27] Adenoid cystic carcinomas, except for the solid variant, have consistently been observed to stain positively for CEA.23*24,26 Intense staining of the luminal aspect of the cells lining the tubules and staining of the luminal contents has been repeatedly documented for the tubular pattern of adenoid cystic carcinoma. In the cribriform variant, CEA staining is described as being mainly re- stricted to the ductlike structures within the tumor.…”