Immunohistochemical detection of adiponectin in atherosclerotic plaque

Танянский, Д. А.; Pigarevsky, Peter V.; Maltceva, S.V.; Denisenko, A.D.

doi:10.1016/j.atherosclerosis.2018.06.393

Cited by 2 publications

(2 citation statements)

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“…The formation and progression of atherosclerotic plaques support the "injury response" hypothesis of this disease, implying that plaque formation is a consequence of the local endothelial lesion associated with the inflammatory process [190,191]. Metabolic syndrome, abdominal obesity, dyslipidemia, insulin resistance, hypertension, serum total and LDL cholesterol, smoking, and aging are related to the development of atherosclerotic lesions in arterial wall [184,192].…”

Section: Arteriosclerosis-atherosclerosismentioning

confidence: 80%

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Almeida

Rezende

Dantas

et al. 2020

Oxidative Medicine and Cellular Longevity

106

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The global population above 60 years has been growing exponentially in the last decades, which is accompanied by an increase in the prevalence of age-related chronic diseases, highlighting cardiovascular diseases (CVDs), such as hypertension, atherosclerosis, and heart failure. Aging is the main risk factor for these diseases. Such susceptibility to disease is explained, at least in part, by the increase of oxidative stress, in which it damages cellular components such as proteins, DNA, and lipids. In addition, the chronic inflammatory process in aging “inflammaging” also contributes to cell damage, creating a stressful environment which drives to the development of CVDs. Taken together, it is possible to identify the molecular connection between oxidative stress and the inflammatory process, especially by the crosstalk between the transcription factors Nrf-2 and NF-κB which are mediated by redox signalling and are involved in aging. Therapies that control this process are key targets in the prevention/combat of age-related CVDs. In this review, we show the basics of inflammation and oxidative stress, including the crosstalk between them, and the implications on age-related CVDs.

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Section: Arteriosclerosis-atherosclerosismentioning

confidence: 80%

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Almeida

Rezende

Dantas

et al. 2020

Oxidative Medicine and Cellular Longevity

106

View full text Add to dashboard Cite

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“…Endocrine functions of adipose tissue are mostly attributed to their ability to secrete adipokines, hormones and cytokines that regulate energy homeostasis and satiety [7] . There are over 600 known adipokines but the most well-studied are the anti-inflammatory adiponectin, which is decreased in obesity, and leptin, which is secreted mostly by WAT and is present unbound in the circulation at higher levels in obesity [63][64][65] . Adipokines are carried by human adipocyte exosomes and leptin has been detected in mouse serum exosomes while adiponectin has been found in rat adipose tissue exosomes [66][67][68] .…”

Section: Adipose Tissuementioning

confidence: 99%

Obesity and atherosclerosis: the exosome link

Reiss¹,

Glass²,

Voloshyna³

et al. 2020

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Obesity is a global public health issue with serious health consequences and rising prevalence. It is a risk factor for a broad range of diseases, particularly atherosclerosis and cardiovascular disease. Long-term weight loss is difficult to achieve, even with diet, life-style changes and anti-obesity drugs. The causes of the association between obesity and atherosclerotic cardiovascular disease are the subject of ongoing investigation. It is known that a chronic surplus in nutritional intake results in expansion and remodeling of adipose tissue, leading to chronic inflammation. Lipid overloaded adipocytes secrete pro-inflammatory adipokines and other mediators that produce this inflammatory state that may in turn, promote atherosclerosis, which is considered an inflammatory disorder. This review discusses the potential role of exosomes from adipose tissue in accelerating atherosclerosis in the setting of obesity. Exosomes are small membrane-bound vesicles that circulate in body fluids and are important participants in intercellular communication both locally and at a distance. They can transfer their cargo of protein, DNA, RNA and microRNA between cells, thus impacting cellular function and signaling. Adipose tissue-derived exosomes may be involved in heightening of the atherogenic environment and, if so, suggests a therapeutic target for the treatment and prevention of cardiovascular complications of obesity.

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Immunohistochemical detection of adiponectin in atherosclerotic plaque

Cited by 2 publications

References 0 publications

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Obesity and atherosclerosis: the exosome link

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