Immunohistochemical description of isotocin neurons and the anatomo-functional comparative analysis between isotocin and vasotocin systems in the weakly electric fish, Gymnotus omaroum

Pouso, Paula; Perrone, Rossana; Silva, Ana C.

doi:10.1016/j.ygcen.2021.113886

Cited by 3 publications

(10 citation statements)

References 81 publications

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“…In addition to oxtr paralogues, the expression of other teleost nonapeptide receptors and in some instances specific paralogues have been localized to tissues relevant to teleost reproduction (63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73) and are summarized in Table 3. Much of our current information on reproductive roles of nonapeptides has been derived from studies of otocephalan species including the airbreathing catfish (4, 5, 24, 84), goldfish (85-87), and zebrafish (35).…”

Section: The Teleost Nonapeptide Receptor Repertoirementioning

confidence: 99%

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

et al. 2022

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The vertebrate nonapeptide families arginine vasopressin (AVP) and oxytocin (OXT) are considered to have evolved from a single vasopressin-like peptide present in invertebrates and termed arginine vasotocin in early vertebrate evolution. Unprecedented genome sequence availability has more recently allowed new insight into the evolution of nonapeptides and especially their receptor families in the context of whole genome duplications. In bony fish, nonapeptide homologues of AVP termed arginine vasotocin (Avp) and an OXT family peptide (Oxt) originally termed isotocin have been characterized. While reproductive roles of both nonapeptide families have historically been studied in several vertebrates, their roles in teleost reproduction remain much less understood. Taking advantage of novel genome resources and associated technological advances such as genetic modifications in fish models, we here critically review the current state of knowledge regarding the roles of nonapeptide systems in teleost reproduction. We further discuss sources of plasticity of the conserved nonapeptide systems in the context of diverse reproductive phenotypes observed in teleost fishes. Given the dual roles of preoptic area (POA) synthesized Avp and Oxt as neuromodulators and endocrine/paracrine factors, we focus on known roles of both peptides on reproductive behaviour and the regulation of the hypothalamic-pituitary-gonadal axis. Emphasis is placed on the identification of a gonadal nonapeptide system that plays critical roles in both steroidogenesis and gamete maturation. We conclude by highlighting key research gaps including a call for translational studies linking new mechanistic understanding of nonapeptide regulated physiology in the context of aquaculture, conservation biology and ecotoxicology.

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Section: The Teleost Nonapeptide Receptor Repertoirementioning

confidence: 99%

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

et al. 2022

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“…The organization of the POA in nucleus preopticus ventricularis anterior (PPa) and posterior (PPp), as was previously described 42,43 , is shown in Fig. 2.…”

Section: Status-dependent Asymmetry In Behaviormentioning

confidence: 79%

“…2). It is also interesting to note that the number of FOS + cells is not signi cantly different between the PPa and PPp despite the PPa has more nonapeptidergic neurons than the PPp 42,43 (Fig. 3).…”

Section: Discussionmentioning

confidence: 91%

“…The presence and neuroanatomical distribution of AVT and IT neurons have been previously described in this species as well as their wide projections to brain areas including those involved in the control of aggression and electromotor behaviors 42,43 . The administration of IT does not modify either locomotor or electromotor activity in isolated individuals 43 , while the effect of IT on the agonistic encounter of G. omarorum has not been previously evaluated. In contrast, the behavioral asymmetry between dominants and subordinates in G. omarorum is somehow paralleled by status-dependent AVT modulations 36 .…”

Section: Introductionmentioning

confidence: 85%

“…In teleost sh, the localization of AVT and IT somata and bers follow a general common pattern with two main cell groups (magnocellular and parvocellular) located in the preoptic area (POA), which are homologous to the amniote supraoptic and paraventricular nuclei of the hypothalamus [40][41][42][43] Several teleost model systems (e.g., Astatotilapia burtoni; Danio rerio) and approaches (e.g., immunohistochemistry, in situ hybridization) have been used to identify neuropeptidergic cellular correlates of the dominant-subordinate status 38,39,41,44,45,46 . However, most previous studies have only focused a) on the status-dependent asymmetries in the number and size of AVTergic neurons 38,39,41,44 but not of IT neurons; and b) on the cellular traits of long-term stable social hierarchies 38,39,41,44 but not of the emergence of the dominant-subordinate status.…”

Section: Introductionmentioning

confidence: 99%

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Involvement of neuropeptidergic neurons in the establishment of dominance in a teleost model of non-breeding aggression: neuropeptide-specific and status-dependent actions

Pouso

Cabana

Francia

et al. 2023

Preprint

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The establishment of the dominant-subordinate status implies a clear behavioral asymmetry between contenders that arises immediately after the resolution of the agonistic encounter and persists during the maintenance of stable dominance hierarchies. Changes in the activity of the brain social behavior network (SBN) are postulated to be responsible for the establishment and maintenance of the dominant-subordinate status. The hypothalamic nonapeptides of the vasopressin/vasotocin (AVP/AVT) and oxytocin/mesotocin/isotocin (OXT/MST/IT) family are known to modulate the activity of the SBN in a context-dependent manner across vertebrates, including status-dependent modulations. We searched for status-dependent asymmetries in AVT/IT cell number and activation immediately after the establishment of dominance in the weakly electric fish, Gymnotus omarorum, which displays the best understood example of non-breeding territorial aggression among teleosts. We used immunolabeling (FOS, AVT, and IT) of preoptic area (POA) neurons after careful designed intermale dyadic agonistic encounters. We show for the first time in teleosts, that AVT, but not IT, is involved in the establishment of the dominant-subordinate status. We also found status-dependent POA subregion-specific changes of AVT cell number and activation that confirm the involvement of AVT in the establishment of dominance likely achieved by the release of AVT from dominants’ AVT neurons.

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Vasotocin but not isotocin is involved in the emergence of the dominant-subordinate status in males of the weakly electric fish, Gymnotus omarorum

Pouso,

Cabana,

Francia

et al. 2024

Hormones and Behavior

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Immunohistochemical description of isotocin neurons and the anatomo-functional comparative analysis between isotocin and vasotocin systems in the weakly electric fish, Gymnotus omaroum

Cited by 3 publications

References 81 publications

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

Involvement of neuropeptidergic neurons in the establishment of dominance in a teleost model of non-breeding aggression: neuropeptide-specific and status-dependent actions

Vasotocin but not isotocin is involved in the emergence of the dominant-subordinate status in males of the weakly electric fish, Gymnotus omarorum

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