Immunohistochemical Demonstration of Tumor Antigen TA-4 in Gynecologic Tumors

Ueda, Gaiko; Inoue, Yoshio; Yamasaki, Masato; Inoue, Masakí; Tanaka, Yoshiaki; Hiramatsu, Kazuko; Saito, Junko; Nishino, Tatsuya; Abe, Yoshihito

doi:10.1097/00004347-198403000-00005

Cited by 26 publications

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“…The present study that mRNA of SCC antigen was expressed in the malignant and nonmalignant squamous epithelium but not in other histologic types of tissues confirmed previous reports using immunohistochemical techniques that the expression of SCC antigen was closely related to squamous cells [4][5][6][7], The present data also showed that mRNA of SCC antigen was detected in the columnar cells of the cervix, but not in the endometri um, which suggested that the cervical colum nar cells would be more related to cervical squamous cells than endometrial cells. This is also supported by our preliminary data that SCC antigen RNA has been detected in some adenocarcinomas of the uterine cervix, but has never been detected in endometrial ade nocarcinoma.…”

Section: Discussionsupporting

confidence: 92%

Expression of mRNA of SCC Antigen in Squamous Cells

et al. 1992

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The expression of SCC antigen mRNA was studied by Northern blot analysis and in situ hybridization in human gynecologic tissues. Northern blot analysis revealed that mRNA of SCC antigen was expressed strongly in normal squamous epithelium and columnar epithelium of the uterine cervix, but not in the endometrium, fallopian tube or ovarian tissue. Among gynecologic malignancies, squamous cell carcinoma of the uterine cervix expressed mRNA of SCC antigen, whereas endometrial and ovarian adenocarcinoma were negative. With in situ hybridization, mRNA of SCC antigen is located in the basal and parabasal layers of the normal squamous epithelium, in dysplasia, and also in carcinoma in situ and invasive squamous cell carcinoma. These results confirmed the previous findings by immunohistochemical studies that SCC antigen is closely related to squamous cells, but also raised a new puzzle regarding the different localization of mRNA and its product, SCC antigen, in the normal squamous epithelium.

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Section: Discussionsupporting

confidence: 92%

Expression of mRNA of SCC Antigen in Squamous Cells

et al. 1992

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“…Though the expression of the SCC antigen mRNA in adenocarcinomas has not been fully investigated, some previous reports support our findings. For example, Ueda et al (1984) reported that the SCC antigen (referred to as TA-4) was detected in some adenocarcinomas of the uterine cervix and less frequently in those of the endometrium. Crombach et al (1989) showed elevated cytosolic SCC antigen protein in adenocarcinomas of the uterine cervix in comparison with other gynaecological adenocarcinomas.…”

Section: Discussionmentioning

confidence: 99%

Detection of lymph node metastasis of oesophageal cancer by RT-nested PCR for SCC antigen gene mRNA

et al. 2000

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Summary With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC) antigen gene as a marker with RT-nested PCR to detect occult lymph node metastases of oesophageal cancer. The SCC antigen has been widely used as a serum tumour marker and was reported as a target gene to detect tumour cells in peripheral blood in cervical cancer. In this study, 620 lymph nodes from 14 oesophageal cancer patients were analysed. The results of RT-nested PCR were compared with that of pathological and immunohistochemical examinations. In the test of sensitivity, the RT-nested PCR detected 10 1 of SCC antigen producing cells in 10 7 peripheral blood mononucleocytes and was not found in 43 control lymph nodes. The pathological examination, immunohistochemical examination and the RT-nested PCR detected 36, 45 and 65 nodes respectively. The RT-nested PCR detected statistically more lymph nodes than the pathological or immunohistochemical examination. The sensitivity and specificity seem higher in squamous cell carcinoma cases. The SCC antigen gene is one of the more useful markers for RT-nested PCR to detect occult lymph node metastases of oesophageal cancer.

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“…However, SCC-Ag is not specific for SCC because elevated levels may occur in patients with other malignancies [15,16] and benign tumors of epithelial origin [17]. Elevated levels of SCC-Ag have also been found in patients with benign skin disorders [16][17][18], e.g.…”

Section: Case Reportmentioning

confidence: 99%

“…Elevated levels of SCC-Ag have also been found in patients with benign skin disorders [16][17][18], e.g. in 83% of the patients with psoriasis, in 80% of those with eczema and in 33% of the patients with miscellaneous skin disorders with inflammatory components [18].…”

Section: Case Reportmentioning

confidence: 99%

Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCGβ but Not Those of SCC Antigen

Lehtovirta¹,

Henrik²,

Vartiainen³

et al. 1999

Tumor Biol

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Squamous cell carcinoma antigen (SCC-Ag) has been shown to be elevated in patients with epidermoid carcinoma of the cervix but also in patients with benign tumors of epithelial origin and in benign skin disorders. Elevated serum levels of the free β subunit of human chorionic gonadotropin (hCGβ) have been observed in patients with cancer of different types, and cancer aggressiveness is related to hCGβ expression. Therefore, we expected that extensive metastatic skin dissemination of gynecologic malignancies would cause a rise in the serum levels of SCC-Ag and hCGβ. The serum levels of SCC-Ag, hCGβ and CA 125 were monitored in 2 patients with extensive skin dissemination of ovarian and endometrial adenocarcinoma. Skin metastases had no effect on serum levels of SCC-Ag but they caused an increase in serum levels of hCGβ. SCC-Ag is not a marker for metastatic skin lesions of gynecologic carcinomas of nonepidermoid origin. hCGβ expression is associated with aggressiveness of cancer and may be a useful marker indicating therapy resistance.

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Immunohistochemical Demonstration of Tumor Antigen TA-4 in Gynecologic Tumors

Cited by 26 publications

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Expression of mRNA of SCC Antigen in Squamous Cells

Expression of mRNA of SCC Antigen in Squamous Cells

Detection of lymph node metastasis of oesophageal cancer by RT-nested PCR for SCC antigen gene mRNA

Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCGβ but Not Those of SCC Antigen

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Immunohistochemical Demonstration of Tumor Antigen TA-4 in Gynecologic Tumors

Cited by 26 publications

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Expression of mRNA of SCC Antigen in Squamous Cells

Expression of mRNA of SCC Antigen in Squamous Cells

Detection of lymph node metastasis of oesophageal cancer by RT-nested PCR for SCC antigen gene mRNA

Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCG&beta; but Not Those of SCC Antigen

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Skin Metastases of Gynecologic Adenocarcinomas Affect Serum Levels of hCGβ but Not Those of SCC Antigen