Immunohistochemical demonstration of the serotonin neuron system in the central nervous system of the bullfrog, Rana catesbeiana

Ueda, Seinosuke; Nojyo, Yoshiaki; Sano, Yutaka

doi:10.1007/bf00315627

Cited by 70 publications

(59 citation statements)

References 36 publications

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“…Muñoz et al, 1995], a similar innervation pattern exists [see also Adli et al, 1988;Petkó and Sánta, 1992]. Additionally, the caudal rhombencephalic alar plate in urodeles is innervated by Leu-enkephalin, neuropeptide Y, and serotonin-immunoreactive fibers, similar to the situation in anurans [Ueda et al, 1984;Merchenthaler et al, 1989;Lázár et al, 1990;A. Muñoz et al, 1995].…”

Section: Organization Of the Urodele Caudal Rhombencephalic Alar Platementioning

confidence: 65%

Organization of the Caudal Rhombencephalic Alar Plate of the Ribbed Newt <i>Pleurodeles waltl: </i>Evidence for the Presence of Dorsal Column and Lateral Cervical Nuclei

Muñoz¹,

Muñoz²,

González³

et al. 1998

Brain Behav Evol

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As part of a recent program on the evolution of somatosensory systems in vertebrates, the cytoarchitecture, chemoarchitecture, and fiber connections of the caudal rhombencephalic alar plate were studied in the ribbed newt, Pleurodeles waltl. This part of the brain stem includes ill-defined dorsal column and lateral cervical nuclei. A cytoarchitectonic analysis revealed that the caudal medullary alar plate consists of an inner and an outer cell layer. The dorsomedial part of the outer cell layer at the obex level contains the dorsal column nucleus (DCN), whereas its ventrolateral part constitutes the lateral cervical nucleus (LCN). NADPH-diaphorase histochemistry and calbindin D-28k immunohistochemistry clearly delineate the main components of the compact inner cell layer, i.e. the nucleus of the solitary tract dorsally and the nucleus of the descending trigeminal tract ventrally. Neither NADPH-diaphorase-labeled nor calbindin D-28k positive neurons were observed in the DCN and LCN. With anterograde and retrograde tracing, the DCN and LCN were further delineated. Labeling of ascending dorsal root projections showed that the dorsal column and the DCN are somatotopically arranged: lumbar primary afferent fibers terminate on medial DCN neurons, whereas cervical primary afferent fibers terminate on lateral DCN neurons. The LCN is densely innervated by the dorsolateral funiculus. Retrograde tracing showed extensive, predominantly contralateral projections of both the DCN and LCN to the torus semicircularis and the ventral thalamus. These data show that even in the poorly segregated caudal rhombencephalic alar plate of urodeles a DCN and LCN can be distinguished with afferent and efferent projections comparable to those in anurans and other terrestrial vertebrates.

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Section: Organization Of the Urodele Caudal Rhombencephalic Alar Platementioning

confidence: 65%

Organization of the Caudal Rhombencephalic Alar Plate of the Ribbed Newt <i>Pleurodeles waltl: </i>Evidence for the Presence of Dorsal Column and Lateral Cervical Nuclei

Muñoz¹,

Muñoz²,

González³

et al. 1998

Brain Behav Evol

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“…Their distribution is very similar to that of sero tonin immunoreactive cells in the tegmentum and they may contribute to the dense serotonergic plexus present in the ventral hypothalamic neuropil [Ueda et al" 1984],…”

Section: Mesencephalonmentioning

confidence: 74%

Afferent Projections to the Hypothalamus in Ranid Frogs

Neary¹

1995

Brain Behav Evol

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Hypothalamic afferents were examined following applications of wheat germ agglutinin-horseradish peroxidase in the infundibulum of bullfrogs (Rana catesbeiana). Neuronal populations were generally labelled bilaterally, with an ipsiIateral predominance. In the telencephalon, most labelled cells were present in the medial pallium, ventral lateral pallium, lateral amygdala, and lateral septal nucleus. A moderate number of cells were found in the medial amygdala and fewer still in the caudal striatum, olfactory tubercle/diagonal band nucleus, medial septal nucleus, and median septum. In the diencephalon, labelled neurons were primarily found in the anterior and central thalamic nuclei, anterior preoptic area, and suprachiasmatic nucleus. Fewer cells were present in the ventral habenular nucleus, anterior division of the lateral thalamic nucleus, posterior thalamic nucleus, ventromedial thalamic nucleus, magnocellular preoptic nucleus, posterior entopeduncular nucleus, and along the medial forebrain bundle. In the midbrain, a few labelled cells were found in the nucleus of the medial longitudinal fasciculus, suprapeduncular nucleus, and posteroventral tegmental nucleus. The secondary isthmal nucleus contained a large number of labelled neurons and moderate numbers of labelled cells were present in the grey medial to nucleus isthmi and in the isthmal raphe. A few lightly labelled cells were also seen in the parabrachial nucleus. Finally, after the largest applications, a few cells were seen in the obex region ventrolateral to the solitary tract.

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“…Thornton and Geschwind (1975) found a dose-dependent potent stimulation of MSH release in the lizard Anolis carolensis. Ueda et al (1984) and Kondo et al (1983) demonstrated the presence of serotonergic fibers in the pars intermedia of Rana catesbeiana. That serotonergic innervation of the pars intermedia might be restricted to lower vertebrate species is suggested by the studies of Kondo and coworkers, who showed that the pars intermedia of the rat, hamster, and dog were serotonin negative.…”

Section: Serotonin In Concentrationsmentioning

confidence: 98%

Regulation of melanotropin release from the pars intermedia of the amphibian Xenopus laevis: Evaluation of the involvement of serotonergic, cholinergic, or adrenergic receptor mechanisms

Kemenade

Jenks

Overbeeke

1986

General and Comparative Endocrinology

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Melanophore-stimulating hormone (MSH) release from the pars intermedia of the pituitary gland is probably regulated by multiple factors of hypothalamic origin. We have examined a number of potential reguiatory factors for their effects on MSH release from the amphibian Xenopus /a&s. Serotonin and acetylcholine have no effect on MSH release. Both adrenaline and noradrenaline inhibit release of MSH in a dose-dependent manner. Studies with specific receptor agonists and antagonists reveal that these neurotransmitters exert their in vitro effects primarily through a dopamine D-2 receptor, although an ol-adrenergic receptor could not be excluded. We further conclude that the pars intermedia of X. laevis lacks a O-adrenergic receptor for the regulation of MSH secretion from the pars intermedia. In mammals, this receptor activates the adenylate cyclase system. Our studies reveal that despite the lack of O-adrenergic receptors, cyclic-AMP is likely an intracellular factor involved in the stimulation of MSH release. 0 1986 Academic PESS, IIIC.

show abstract

Immunohistochemical demonstration of the serotonin neuron system in the central nervous system of the bullfrog, Rana catesbeiana

Cited by 70 publications

References 36 publications

Organization of the Caudal Rhombencephalic Alar Plate of the Ribbed Newt <i>Pleurodeles waltl: </i>Evidence for the Presence of Dorsal Column and Lateral Cervical Nuclei

Organization of the Caudal Rhombencephalic Alar Plate of the Ribbed Newt <i>Pleurodeles waltl: </i>Evidence for the Presence of Dorsal Column and Lateral Cervical Nuclei

Afferent Projections to the Hypothalamus in Ranid Frogs

Regulation of melanotropin release from the pars intermedia of the amphibian Xenopus laevis: Evaluation of the involvement of serotonergic, cholinergic, or adrenergic receptor mechanisms

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