Immunohistochemical demonstration of somatostatin-positive cells in the canine gut.

Ito, Seiki; Yamada, Yukio; Kobayashi, Shigeru

doi:10.1620/tjem.121.85

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…The pattern of immunocytochemical staining presently observed in the pancreatic islets (Table 1) agrees with numerous reports on the localization of insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-containing cells (for review see Erlandsen, 1980). Further, these results are consistent with previous studies on the localization of gastrointestinal endocrine cells (Tables 2,3) containing glucagon (Baetens et al, 1976); the gut glucagonlike material, glicentin (Larsson et al, 1975;Garaud et al, 1980); somatostatin Leclerc et al, 1976;Alumets et al, 1977;Ito et al, 1977;Forssmann et al, 1978); and pancreatic polypeptide (Larsson et al, 1976).…”

Section: Discussionsupporting

confidence: 93%

Immunocytochemical localization of glucagonlike and gastric inhibitory polypeptidelike peptides in the pancreatic islets and gastrointestinal tract

Smith

1983

Am. J. Anat.

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The distribution of cells displaying glucagonlike or gastric inhibitory polypeptide (GIP)-like immunoreactivity was examined in the pancreatic islets and gastrointestinal tracts of rats, dogs, and humans. A-cells in the pancreatic islets in all three species were stained by antisera having regional specificity for pancreatic-type glucagon, gut-type glucagon (glicentin), or GIP. Oxyntic A-cells of the gastric mucosa in dogs and humans also were stained comparably by these three antisera. In contrast, the K- and L-cells in the intestinal mucosa of those species were stained only by antisera capable of reacting with GIP or gut-type glucagon, respectively. Tests of antibody specificity showed that the GIP antiserum did not cross-react with either pancreatic- or gut-type glucagon. Likewise, the glucagon antisera showed no cross-reactivity with GIP. Hence, these findings suggest that pancreatic and gastric A-cells contain a peptide with GIP-like immunoreactivity distinct from glucagon or glicentin per se. Although the exact basis of th GIP-like immunostaining of A-cells is unknown, it may be due to the presence of a glucagon precursor sharing certain amino-acid sequences with GIP. This hypothesis is consistent with several recent investigations showing that the processing of proglucagon molecules differs between the A- and L-cells.

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Section: Discussionsupporting

confidence: 93%

Immunocytochemical localization of glucagonlike and gastric inhibitory polypeptidelike peptides in the pancreatic islets and gastrointestinal tract

Smith

1983

Am. J. Anat.

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“…The immunizing procedure has been reported previously (Ito et al 1977). The antiserum obtained 10 days after the sixth injection was used in the present study .…”

Section: Antiseramentioning

confidence: 99%

Neurotensin-positive and somatostatin-positive cells in the canine gut.

Ito

Yamada

Hayashi

et al. 1979

Tohoku J. Exp. Med.

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Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog

1978

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The interaction between motilin and somatostatin on gastrointestinal motor activity was studied in fasted, unanesthetized dogs. Contractions of the stomach, duodenum, jejunum, and ileum were recorded with extraluminal strain gage force transducers. Motilin initiated a pattern of contractile activity which closely resembled phase III of the interdigestive motor complex. Somatostatin delayed the onset of the motilin response and reduced motor activity in the stomach and the jejunum. During somatstatin infusion the motilin-induced contractile pattern did not migrate to the jejunum. The cycle of natural interdigestive motor complexes was also interrupted by somatostatin. Somatostatin alters natural and motilin-induced interdigestive migrating motor complexes of the canine gastrointestinal tract.

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Immunohistochemical demonstration of somatostatin-positive cells in the canine gut.

Cited by 5 publications

References 16 publications

Immunocytochemical localization of glucagonlike and gastric inhibitory polypeptidelike peptides in the pancreatic islets and gastrointestinal tract

Immunocytochemical localization of glucagonlike and gastric inhibitory polypeptidelike peptides in the pancreatic islets and gastrointestinal tract

Neurotensin-positive and somatostatin-positive cells in the canine gut.

Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog

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