Immunohistochemical demonstration of somatostatin-containing cells in the human placenta.

Nishihira, Morimi; Yagihashi, Soroku

doi:10.1620/tjem.126.397

Cited by 24 publications

(7 citation statements)

References 3 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the peculiar features of placental endocrinology is that in some instances it mimics the function of other endocrine glands. Somatostatin, the GH-inhibiting hormone, has been found in human placenta (14) by immunohistochemical studies revealing its localization in the cytotrophoblast and in the stroma of placental villi. Available evidences demonstrate the presence of GH regulatory hormones that are prevalently hypothalamic.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin, A Novel Placental-Derived Hormone¹

et al. 2001

View full text Add to dashboard Cite

Ghrelin, a GH-releasing acylated peptide, has been recently identified from the rat stomach. The purified peptide consists of 28 amino acids in which the serine 3 residue is n-octanoylated. Here we show that ghrelin messenger RNA and ghrelin peptide are present in the human as well as in rat placentae. In human placenta, ghrelin was detected by PCR at both first trimester and after delivery. While ghrelin was not detected by immunohistochemistry in human placenta at term, it was easily identified by immunohistochemistry at first trimester being mainly expressed in cytotrophoblast cells and scarcely in syncytiotrophoblast ones. Ghrelin was also identified in a human choriocarcinoma cell line, the BeWo cells. Ghrelin was found, by immunohistochemistry, in the cytoplasm of labyrinth trophoblast of rat placenta, whereas other placental cell types seems to be negative for ghrelin immunostaining. Moreover, placental ghrelin messenger RNA, in pregnant rats, showed a characteristic profile of expression being practically undetectable during early pregnancy, with a sharp peak of expression at day 16 and decreasing in the latest stages of gestation. In conclusion, ghrelin has been detected in human and rat placenta showing a pregnancy-related time course of expression. Whether placenta-derived ghrelin is involved in the modulation of GH release, or placental cell growth and differentiation remains to be established.

show abstract

Section: Discussionmentioning

confidence: 99%

Ghrelin, A Novel Placental-Derived Hormone¹

et al. 2001

View full text Add to dashboard Cite

show abstract

“…The extrahypothalamic origin of this peptide has also been well documented in a variety of tissues including the pancreases and gastrointestinal tracts of rats and man (Arimura, Sata, Dupont et al 1975;Mclntosh, Arnold, Bothe et al 1978) and human placenta (Nishihira & Yagihashi, 1978). The studies of Mori, Saito, Ohno et al (1984) provide evidence for the presence of SRIF-14-like immunoreactivity in porcine ovaries.…”

Section: Introductionmentioning

confidence: 91%

Inhibitory action of somatostatin-14 on hormone-stimulated cyclic adenosine monophosphate induction in porcine granulosa and luteal cells

Rajkumar

Kerr²,

Kirkwood³

et al. 1992

Journal of Endocrinology

View full text Add to dashboard Cite

Somatostatin-14 (SRIF-14) inhibited, in a concentration-dependent manner, LH- and forskolin-stimulated cyclic adenosine monophosphate (cAMP) induction in porcine granulosa and luteal cells. The inhibitory effect of SRIF-14 on hormone-induced cAMP generation was more potent in porcine ovarian cells than in the GH-3 pituitary cell line. The inhibitory effect of SRIF-14 was impeded by neutralizing its biological activity with specific antiserum. Preincubation of luteal and granulosa cells with phorbol 12-myristate 13-acetate (PMA) enhanced LH- and forskolin-stimulated cAMP levels. SRIF-14 failed to inhibit LH- or forskolin-stimulated cAMP levels in cells preincubated with PMA. It is concluded that SRIF-14 inhibits hormone-stimulated cAMP induction in the porcine ovary. LH-induced protein kinase C activation may be physiologically important to alleviate the inhibitory effects of SRIF-14.

show abstract

“…Since the first report of somatotrophin releaseinhibiting factor (SRIF) isolated from ovine hypo¬ thalamus (Brazeau et al 1973), extrahypothalamic origin of the peptide has been well documented with a variety of tissues including the pancreas and gastrointestinal tracts of rats and humans Mclntosh et al 1978), and human placenta (Nishihira & Yagihashi 1978). However, attemps have so far failed to demonstrate the presence of this peptide in the gonads (Brownstein et al 1975).…”

mentioning

confidence: 99%

Evidence for existence of somatostatin-like immunoreactivity with molecular heterogeneity in porcine ovaries

Mori¹,

Saito²,

Ohno³

et al. 1984

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

Immunohistochemical demonstration of somatostatin-containing cells in the human placenta.

Cited by 24 publications

References 3 publications

Ghrelin, A Novel Placental-Derived Hormone¹

Ghrelin, A Novel Placental-Derived Hormone¹

Inhibitory action of somatostatin-14 on hormone-stimulated cyclic adenosine monophosphate induction in porcine granulosa and luteal cells

Evidence for existence of somatostatin-like immunoreactivity with molecular heterogeneity in porcine ovaries

Contact Info

Product

Resources

About

Immunohistochemical demonstration of somatostatin-containing cells in the human placenta.

Cited by 24 publications

References 3 publications

Ghrelin, A Novel Placental-Derived Hormone1

Ghrelin, A Novel Placental-Derived Hormone1

Inhibitory action of somatostatin-14 on hormone-stimulated cyclic adenosine monophosphate induction in porcine granulosa and luteal cells

Evidence for existence of somatostatin-like immunoreactivity with molecular heterogeneity in porcine ovaries

Contact Info

Product

Resources

About

Ghrelin, A Novel Placental-Derived Hormone¹

Ghrelin, A Novel Placental-Derived Hormone¹