Immunohistochemical demonstration of enamel proteins in odontogenic tumors

Saku, Takashi; Okabe, Haruo; Shimokawa, Hitoyata

doi:10.1111/j.1600-0714.1992.tb00993.x

Cited by 87 publications

(81 citation statements)

References 28 publications

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“…Similar findings have been reported by Leon et al [8] and Jivan et al [14]. It has been shown that tumor droplets in AOTs are immunopositive for enamel proteins, such as enamelin, amelogenin and sheathlin, supporting a probable enamel nature for this material [27,28]. Variable amounts of calcified material have been reported in most cases of AOT [2,8,22] and the present results corroborate these observations.…”

Section: Discussionsupporting

confidence: 92%

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Matos

Nonaka

Pinto

et al. 2012

Head and Neck Pathol

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Adenomatoid odontogenic tumor (AOT) is an uncommon benign epithelial lesion of odontogenic origin and, thus far, only few studies regarding the frequency of its many histopathologic features have been published in the literature. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features. Fifteen cases of AOT were studied considering their clinical, radiographic and histopathologic aspects. Twelve cases affected females and the mean age was 16.2 years. The anterior maxilla was the most common site (66.6 %) and radiographically most cases showed a unilocular radiolucency with well-defined borders (57.1 %). Histologically, most cases exhibited predominantly a solid growth pattern (46.7 %) or a similar proportion of solid and cribriform patterns (46.7 %). Eosinophilic amorphous material (''tumor droplets'') was found in all cases (100 %). Most tumors showed duct-like spaces (93.3 %) and convoluted structures (60.0 %) whereas a minor proportion of cases presented calcifying epithelial odontogenic tumor (CEOT)-like areas (26.7 %). Variable amounts of calcified material were found in most AOTs (80.0 %) whereas osteodentin and perivascular hyalinization were seen only rarely (6.7 % each one). Five (33.3 %) cases had areas mimicking a dentigerous cyst and most of these were diagnosed in females (80.0 %). Regarding the histopathologic features, our results suggest that AOTs usually show predominance of solid pattern or a similar proportion of solid and cribriform patterns while osteodentin and perivascular hyalinization are rarely seen in these tumors. In addition, areas mimicking a dentigerous cyst and CEOT-like areas are relatively infrequent findings in AOTs.

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Section: Discussionsupporting

confidence: 92%

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Matos

Nonaka

Pinto

et al. 2012

Head and Neck Pathol

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“…Amelogenin i enukleacija u malim tumorskim ćelijama i kapljicama hijalina nađeni su mineralizovani fokusi 44 . Kako sve varijante tumora imaju kapsulu, trapiski izbor je hirurška enukleacija i kiretaža promene 23 .…”

Section: Discussionunclassified

Clinical and radiographic features of adenomatoid odontogenic tumour

Madiyal¹,

Ajila²,

Hegde³

et al. 2016

Acta stomatologica Naissi

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“…Occasionally, extensive clear cell differentiation has also been reported [6]. The biochemical significance and origin of eosinophilic material is still controversial but several possibilities suggested include keratin, enamel matrix, amelogenin and enamelin [7,8]. Recently, newer variants of CEOT like non-calcifying CEOT with langerhans cells, CEOT displaying cementum and bone like material and a combined adenomatoid odontogenic tumor and CEOT have also been described [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor)

Angadi¹,

Rekha²

2011

Head and Neck Pathol

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The calcifying epithelial odontogenic tumor is a benign epithelial tumor with characteristic clinical and histopathologic features. These features are discussed with a typical case presentation along with emphasis on newer variants and management strategies.Keywords Calcifying epithelial odontogenic tumor Á Pindborg tumor Á Maxilla Case ReportHistory A 30 year old male presented to our institution with a gradually progressive swelling for the past year. Extraoral examination revealed a solitary diffuse swelling on the right side of face measuring around 3 9 4 cm in size and obliterating the nasolabial fold. The swelling extended from 0.5 cm below the infraorbital margin to angle of the mouth and from the ala of the nose to the outer canthus mediolaterally. It was nontender and hard in consistency on palpation. Intraoral examination, revealed a solitary, diffuse swelling extending from right maxillary lateral incisor to the second molar. There was obliteration of the buccal vestibule while palatally, the swelling extended from the gingival margin to the raphe region in relation to the right upper premolars and molars. The mucosa over the swelling was stretched but intact (Fig. 1a, b). Radiographic FeaturesThe panoramic radiograph revealed a well-defined radiolucency extending from the right maxillary lateral incisor to the 2nd molar with radiopacities dispersed within and associated with an impacted canine. ManagementThe patient was taken for surgery and the lesion was removed in toto (Fig. 2a). The gross specimen measured 4 9 3 cm and was a well-encapsulated round to ovoid cystic mass. It revealed regular borders, smooth surface and was firm to hard in consistency. Cut surface showed lesion to be granular with tooth completely embedded within the calcifications, which were sandy in consistency (Fig. 2b). HistopathologyThe hematoxylin and eosin stained sections revealed sheets of epithelial cells with prominent intercellular bridges, nuclear pleomorphism and hyperchromatism interspersed with eosinophilic amyloid like material and basophilic irregular to concentric calcifications. A diagnosis of calcifying epithelial odontogenic tumor was made by clinicopathologic correlation (Fig. 3a, b).

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Immunohistochemical demonstration of enamel proteins in odontogenic tumors

Cited by 87 publications

References 28 publications

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Clinical and radiographic features of adenomatoid odontogenic tumour

Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor)

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