Immunohistochemical Characterization of a Duodenal Adenocarcinoma with Pulmonary, Hepatic and Parapatellar Metastases in a Common Marmoset (Callithrix jacchus)

Peterson, Curt M.; Plunkard, Jessica; Johanson, Andrew; Izzi, Jessica; Gabrielson, Kathleen L.

doi:10.1016/j.jcpa.2021.09.002

Cited by 1 publication

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“…[114][115][116] While small intestinal adenocarcinomas are rare in other NHPs and man, it is the most common neoplasm affecting morbidity and mortality in common marmosets, even with extensive metastasis. 116,117 In this example, an adenocarcinoma from the small intestines has metastasized to the lung (Figures 5 and 6). Less common or rarely reported malignant neoplasia includes malignant nephroblastoma, rhabdomyosarcoma, lymphoma, myeloid sarcoma, and apocrine gland adenocarcinoma.…”

Section: Marmosets Rarely Develop Spontaneous Cancersmentioning

confidence: 95%

The Common Marmoset—Biomedical Research Animal Model Applications and Common Spontaneous Diseases

Han

2022

Toxicol Pathol

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Marmosets are becoming more utilized in biomedical research due to multiple advantages including (1) a nonhuman primate of a smaller size with less cost for housing, (2) physiologic similarities to humans, (3) translatable hepatic metabolism, (4) higher numbers of litters per year, (5) genome is sequenced, molecular reagents are available, (6) immunologically similar to humans, (7) transgenic marmosets with germline transmission have been produced, and (8) are naturally occurring hematopoietic chimeras. With more use of marmosets, disease surveillance over a wide range of ages of marmosets has been performed. This has led to a better understanding of the disease management of spontaneous diseases that can occur in colonies. Knowledge of clinical signs and histologic lesions can assist in maximizing the colony’s health, allowing for improved outcomes in translational studies within biomedical research. Here, we describe some basic husbandry, biology, common spontaneous diseases, and animal model applications for the common marmoset in biomedical research.

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Section: Marmosets Rarely Develop Spontaneous Cancersmentioning

confidence: 95%

The Common Marmoset—Biomedical Research Animal Model Applications and Common Spontaneous Diseases

Han

2022

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

Immunohistochemical Characterization of a Duodenal Adenocarcinoma with Pulmonary, Hepatic and Parapatellar Metastases in a Common Marmoset (Callithrix jacchus)

Cited by 1 publication

References 32 publications

The Common Marmoset—Biomedical Research Animal Model Applications and Common Spontaneous Diseases

The Common Marmoset—Biomedical Research Animal Model Applications and Common Spontaneous Diseases

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