Immunohistochemical assessment of Viadent®-associated leukoplakia

Anderson, Kimberly M.; Stoner, Gary D.; Fields, Henry W.; Chacon, Guillermo E.; Dohar, Amanda L.; Gregg, Benjamin R.; Mallery, Susan R.

doi:10.1016/j.oraloncology.2004.08.008

Cited by 16 publications

(10 citation statements)

References 16 publications

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“…Argemone oil increases incidence of bladder cancer in animal models [103] and of gall bladder cancer in humans [104] . Furthermore, sanguinarine extract from bloodroot (Sanguinaria canadensis), previously used in oral hygiene products, was discontinued until a link between product administration and occurrence of leukoplakia was established [105,106] . Hepatic microsomes transform sanguinarine in a mutagenic epoxide and the same sanguinarine is capable of activating polycyclic aromatic hydrocarbon signaling [107] .…”

Section: Resultsmentioning

confidence: 99%

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Gaziano

Moroni

Buè

et al. 2016

WJGO

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Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis , and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice.

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Section: Resultsmentioning

confidence: 99%

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Gaziano

Moroni

Buè

et al. 2016

WJGO

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“…Variation in p16 positive staining criteria should be considered. Some studies evaluated only nuclear staining (20, 21), whereas another study utilized both nuclear and/or cytoplasmic staining (14). According to a study, cytoplasmic expression of p16 was found to correlate with poor prognosis in high‐grade astrocytomas (22).…”

Section: Discussionmentioning

confidence: 99%

Expression of p16 in oral cancer and premalignant lesions

Buajeeb

Poomsawat

Punyasingh

et al. 2008

J Oral Pathology Medicine

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“…Native Americans had several uses for bloodroot, including use as dyes and medicines. Today, this plant is most widely used in dental care products as a remineralizing or antigingivial agent (14,23), though some note an association between use and oral malignancies, such as leukoplakia (1). …”

Section: Introductionmentioning

confidence: 99%

Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model

Senchina

Flinn

McCann

et al. 2009

J. of Herbs, Spices & Medicinal Plants

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Previous studies have suggested that phytomedicinal preparations from bloodroot (Sanguinaria canadensis L.) may harbor immunomodulatory properties. The purpose of this investigation was to determine the effects of alcohol tinctures and water infusions generated from bloodroot flowers, leaves, rhizomes, and roots on human peripheral blood mononuclear cell (PBMC) cytokine production and proliferation in vitro. PBMCs were collected from 16 healthy young adults and cultured with bloodroot extracts or respective controls for interleukins-1β, -2, -8, -10, interferon-γ, and tumor necrosis factor. Proliferative capabilities of both PBMCs and K562 cells (an immortalized human myelogenous leukemia cell line) following extract treatment were determined. High-pressure liquid chromatography was used to quantify berberine, chelerythrine, and sanguinarine in the extracts and to correlate extract composition with observed effects. Overall, infusions demonstrated greater immunomodulatory capabilities than tinctures, and flower-and root-based extracts showed greater immunomodulatory properties than leaf-or rhizome-based extracts (some effects seen with rootbased extracts may be due to endotoxin). Several extracts were able to augment PBMC proliferation and diminish K562 proliferation, suggesting a selective anti-carcinogenic activity. The rhizome alcohol tincture had a markedly stronger effect against K562 cells than other extracts. Chelerythrine, sanguinarine, and endotoxin (but not berberine) sometimes correlated with observed effects. The in vitro activities demonstrated here suggest bloodroot extracts may have potential as therapeutic immunomodulators.

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Immunohistochemical assessment of Viadent®-associated leukoplakia

Cited by 16 publications

References 16 publications

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Expression of p16 in oral cancer and premalignant lesions

Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model

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