Immunohistochemical Assessment of the Compensatory Responses in Rat Olfactory Bulbs after 6-Hydroxydopamine-Induced Lesion of the Substantia Nigra

Olfactory Bulb D2/D3 Receptor Availability after Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

“…Although a few studies have described the 6-OHDA animal model with unilateral or bilateral lesion of the SN or the OB, or both [107][108][109][110][111][112][113], no olfactory behavior tests have been performed. A few studies using these tests have been done, however, only in differently designed 6-OHDA or MPTP mouse models [76,101,104,114,115] or in mice with neurodegenerative diseases, such as Niemann-Pick Disease Type C1 [116].…”

“…There are only two studies whose results demonstrated increased numbers of THimmunoreactive neurons after unilateral lesion trials in rats. Winner et al [96] described changes 6 weeks after unilateral lesion of the MFB, and Voronkov et al [110] reported an increase after unilateral SN lesion. The latter authors interpreted this as a possible compensatory process, and argued that a more pronounced dopamine-related inhibitory effect in the glomeruli of the OB could contribute to the development of hyposmia in PD.…”