Immunohistochemical and Ultrastructural Studies of Experimental Epithelial Dysplasia Induced by Excisional Wounding and Trp-P-2 Application in Hamster Tongues.

Histological and Immunohistochemical Study of Effects of TGF-.ALPHA. and Trp-P-2 on Transplanted Organ-cultured Mouse Tooth Germ

“…Histometrically, in Group D, the size of the transplanted organ-cultured tooth germ was smaller than that of Group A. As mentioned earlier, Trp-P-2 was a potent mutagenic substance from pyrolysates of tryptophan (8,9,10). It was described that, after Trp-P-2 subcutaneous administration in neonatal ICR mice, all animals developed tumors of the liver and lymphoreticular tissue (8).…”

“…Of these growth factors, TGF-was first detected in the medium of murine sarcoma virus-transformed cells and several other retrovirus-transformed fibroblasts; yet TGF-expression was not restricted to tumors, but was very common in normal cells, especially epithelial cells (7). Many mutagenic heterocyclic amines have been isolated from pyrolysates of amino acid and from protein in boiled fish and meat, as well as from beef extract (8,9,10) and shown to be carcinogenic in animals (8,9,10). Trp-P-2 (3-amino-1-methyl-5H-pyrido [4, 3-b] indole) is one of these heterocyclic amines.…”

DNA Vaccine against Hamster Oral Papillomavirus-associated Oral Cancer

“…2 Furthermore, viral particles resembling papillomavirus, 50 -55 nm in diameter, were detected in the nuclei of these cells. 3 Using the same animal model, we also demonstrated the presence of a novel hamster papillomavirus by molecular cloning and sequencing of the viral genome. 4 The genome was confirmed by complete sequence analysis to be a novel papillomavirus, and was designated the had open reading frames (ORFs) on one strand in the usual order: E6, E7, E1, E2, L2 and L1.…”