Immunohistochemical and histopathological analyses of cutaneous innervation to improve the diagnostic efficacy in hansen disease skin lesion
Eduardo Alves Freire da Costa,
Thaís Porto Amadeu,
Ximena Illarramendi
et al.
Abstract:Background The diagnosis of Hansen disease (HD) can be difficult when acid-fast bacilli are not detected in the patient's skin sample.
Objective To demonstrate that detailed morphological analysis of nonspecific inflammatory and/or noninflammatory alterations in dermal nerves as well as skin adnexa in leprosy-suspected biopsy samples could improve the efficacy of histopathological diagnosis.
Methods Patients with one to five skin lesions were enrolled in the study and classified into three … Show more
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