Immunohistochemical and electron microscopic findings in benign fibroepithelial vaginal polyps.

Rollason, T. P.; Byrne, Philip; Williams, Ann

doi:10.1136/jcp.43.3.224

Cited by 42 publications

(25 citation statements)

References 13 publications

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“…Variation in appearance of the stroma and the proportions of spindle-shaped and stellate cells is similar to reports in women in which it ranges from loose fibroconnective tissue to thick hyalinized bundles of collagen (Nucci et al, 2000). The presence of stellate cells is a striking and characteristic histological feature of polyps in women (Rollason et al, 1990). Scattered multinucleate cells are also described as a distinctive feature in women, but are often not clearly distinguishable (Al-Nafussi et al, 1992;Nucci et al, 2000).…”

mentioning

confidence: 53%

Fibroepithelial Polyps of the Vagina in Bitches: a Histological and Immunohistochemical Study

Brown

Evans

Deen

et al. 2012

Journal of Comparative Pathology

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mentioning

confidence: 53%

Fibroepithelial Polyps of the Vagina in Bitches: a Histological and Immunohistochemical Study

Brown

Evans

Deen

et al. 2012

Journal of Comparative Pathology

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“…On the other hand, multinucleated stromal giant cells have been noted frequently in the normal anal mucosa and probably develop in response to prolonged local irritation 11 . Similar atypical cells, considered to be reactive, have also been described in the fibroepithelial polyps arising from other sites 5,12–21 …”

Section: Discussionmentioning

confidence: 97%

CD34+ stromal cells and hyalinized vascular changes in the anal fibroepithelial polyps

Sakai

Matsukuma

2002

Histopathology

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“…Histologically, fibroepithelial polyps are composed of a squamous epithelial surface with a fibrovascular stalk and edematous stroma [6]. The lesions, when bland or hypocellular, are readily recognized as benign.…”

Section: Discussionmentioning

confidence: 97%

Vaginal polyp: an unusual cause of postmenopausal bleeding

Putran

Gupta

2010

Gynecol Surg

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Postmenopausal bleeding (PMB) can be due to various causes. The commonest cause is atrophy of the vagina or the endometrium. Endometrial cancer accounts for 10% cases of PMB. We present this unusual case of fibroepithelial polyp of the vagina as a cause for PMB. Vaginal fibroepithelial polyp is a rare lesion, and although benign, it can be confused with malignant connective tissue lesions. Treatment is simple excision, and recurrence is extremely uncommon.A 67-year-old woman presented with a history of postmenopausal bleeding (PMB) for 2 months. She suffered from type 1 diabetes and essential hypertension. She had a past history of breast carcinoma and was on tamoxifen. On examination, her body mass index (BMI) was 41. Abdominal examination was inconclusive and vaginal examination not possible as she was a virgo intacta. An abdominal ultrasound demonstrated a 7×4-cm-sized retroverted uterus with endometrial thickness of 11 mm. She was booked for examination under anesthesia and hysteroscopy. This was difficult due to poor access due to body habitus and a small introitus. A 1×2-cm friable growth was noted in the anterior vaginal wall 2 cm above the external urethral orifice. The mass was removed and sent for urgent histology. Cervix was healthy. Saline hysteroscopy, endometrial biopsy, and subsequent histology were normal with no evidence of endometrial pathology.The vaginal bleeding had settled when the woman was reviewed 6 weeks and 6 months after the surgery. The vaginal lesion was subsequently diagnosed as benign fibroepithelial polyp on histology. DiscussionPMB represents one of the most common reasons for referral to gynecological services, largely due to suspicion of an underlying endometrial malignancy. Possible causes in order of frequency include atrophic endometritis and vaginitis, exogenous estrogens, endometrial carcinoma, endometrial or cervical polyps, endometrial hyperplasia, cervical carcinoma, ring pessary, and ovarian estrogensecreting tumors.Endometrial cancer is present in approximately 10% of patients referred with PMB. In the above woman, the clinical suspicion for endometrial carcinoma was high. She was hence booked for urgent hysteroscopy and endometrial biopsy. However, the final cause of the PMB was the fibroepithelial polyp in the vagina.Fibroepithelial polyp of the vagina was first described by Norris and Taylor in 1966. Although benign, it can be confused with malignant connective tissue lesions because of its bizarre histology. They typically occur in women of reproductive age but may be seen in postmenopausal women specially those on hormone replacement therapy [1].The mean age at diagnosis is approximately 40 years, with an age range varying from that of the newborn child to 77 years. Fibroepithelial polyp as a cause of PMB is rare [2,3].

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Immunohistochemical and electron microscopic findings in benign fibroepithelial vaginal polyps.

Cited by 42 publications

References 13 publications

Fibroepithelial Polyps of the Vagina in Bitches: a Histological and Immunohistochemical Study

Fibroepithelial Polyps of the Vagina in Bitches: a Histological and Immunohistochemical Study

CD34+ stromal cells and hyalinized vascular changes in the anal fibroepithelial polyps

Vaginal polyp: an unusual cause of postmenopausal bleeding

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