Immunohistochemical analysis of tumor budding in stage II colon cancer: exploring zero budding as a prognostic marker
Maria Pihlmann Kristensen,
Ulrik Korsgaard,
Signe Timm
et al.
Abstract:Tumor budding, a biomarker traditionally evaluated using hematoxylin and eosin (H&E) staining, has gained recognition as a prognostic biomarker for stage II colon cancer. Nevertheless, while H&E staining offers valuable insights, its limitations prompt the utilization of pan-cytokeratin immunohistochemistry (IHC). Consequently, this study seeks to evaluate the prognostic significance of tumor budding using IHC in a contemporary cohort of stage II colon cancer patients, aiming to deepen our understandin… Show more
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