Immunohistochemical Analysis of P53 and PRB in Esophageal Squamous Cell Carcinoma

Dey, Biswajit; Raphael, Vandana; Khonglah, Yookarin; Lynrah, Kyrshanlang G

doi:10.7860/jcdr/2014/7428.4309

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…Only 14 (19%) studies reported a minimum biopsy quantity or quality as a study inclusion criterion, each of them setting a different threshold (Table ). Twenty‐four (32%) studies provided no information regarding the quantity of material used to perform the test . Among studies reporting RNA expression, up to 2 μg appeared to be extractable from one single fresh/frozen biopsy, however, the authors reported neither the size nor relative tumour content of the biopsies used.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four (32%) studies provided no information regarding the quantity of material used to perform the test. 7,11,13,15,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Among studies reporting RNA expression, up to 2 lg appeared to be extractable from one single fresh/frozen biopsy, 9,16 however, the authors reported neither the size nor relative tumour content of the biopsies used. None of the studies provided a rationale for choosing a particular quantity or quality.…”

Section: Q U a N T I T Y A N D Q U A L I T Y O F E N D O S C O P I C mentioning

confidence: 99%

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Endoscopic biopsies from gastrointestinal carcinomas and their suitability for molecular analysis: a review of the literature and recommendations for clinical practice and research

et al. 2015

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Endoscopic biopsies (EBs) are the gold standard for diagnosing gastrointestinal carcinoma yet no guidelines address EB use for prognostic and predictive molecular testing. This review summarizes the reported quantity and quality of EBs, their relationship with molecular test failure rates and the resultant concordance between EB and resection specimen. Studies reporting molecular testing on gastrointestinal carcinoma EBs published between 2002 and 2014 were identified. Details regarding EB quantity, quality, tumour content, molecular test failure rates as well as causes and concordance with resection specimens were reviewed. Seventy-five studies were identified. Eighteen (24%) reported the mean EB number per patient (median: 2.1, range: 1-6.6 EBs). Sixty-one (81%) reported the frequency of test failure (median: 0%, range: 0-100%). Twenty-two (29%) investigated EB and resection specimen concordance (range: 0-100%). EB quantity and quality affected neither concordance nor failure rate. In summary, few studies currently report EB quantity, EB quality or EB and resection specimen concordance. Reliable molecular testing in EBs appears achievable, and can be representative of resection specimens. Concordance depends upon the testing methodology and biomarker heterogeneity within the tumour. To improve patient care, EB sampling, processing and reporting requires standardization and needs optimization for each biomarker individually.

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Section: Resultsmentioning

confidence: 99%

Section: Q U a N T I T Y A N D Q U A L I T Y O F E N D O S C O P I C mentioning

confidence: 99%

Endoscopic biopsies from gastrointestinal carcinomas and their suitability for molecular analysis: a review of the literature and recommendations for clinical practice and research

et al. 2015

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“…In esophageal squamous cell carcinoma, inactive pRB was significant associated with with adverse prognosis (Contu et al, 2007;Wang et al, 2013;Dey et al, 2014) . Our results present that RB1 polymorphism was predominately associated with the efficacy of platinum-taxanes in squamous cell lung cancer.…”

Section: Discussionmentioning

confidence: 99%

RB1 Polymorphism Contributes to the Efficacy of Platinum-Taxanes in Advanced Squamous Cell Lung Cancer

Liu

Xu²,

Zhang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…ESCC, which is a predominant histologic subtype of esophageal cancer, has an overall 5-year survival rate of 14%. 4 Metastases of ESCC to the bone are uncommon and vary from 1 to 14% in autopsy series. 5 In clinical practice, bone metastases of esophagus cancer occurred infrequently.…”

Section: Discussionmentioning

confidence: 99%

Occult Esophageal Squamous Cell Carcinoma Presenting with Multiple Bony Osteolytic Lesions Clinically Mimicking Multiple Myeloma: A Diagnostic Dilemma

Lyngdoh

Dey

Raphael

et al. 2020

JLP

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Bone metastasis as an initial presentation of esophageal carcinoma is uncommon. In the absence of typical presentations like dysphagia, these cases may lead to diagnostic dilemmas both for the clinicians and pathologists. Here, we report a case of disseminated metastasis of esophageal squamous cell carcinoma to the bone in a 47-year-old female, who presented with multiple osteolytic lesions and clinically mimicking multiple myeloma. A detailed diagnostic work-up established the diagnosis of esophageal squamous cell carcinoma.

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Immunohistochemical Analysis of P53 and PRB in Esophageal Squamous Cell Carcinoma

Cited by 8 publications

References 14 publications

Endoscopic biopsies from gastrointestinal carcinomas and their suitability for molecular analysis: a review of the literature and recommendations for clinical practice and research

Endoscopic biopsies from gastrointestinal carcinomas and their suitability for molecular analysis: a review of the literature and recommendations for clinical practice and research

RB1 Polymorphism Contributes to the Efficacy of Platinum-Taxanes in Advanced Squamous Cell Lung Cancer

Occult Esophageal Squamous Cell Carcinoma Presenting with Multiple Bony Osteolytic Lesions Clinically Mimicking Multiple Myeloma: A Diagnostic Dilemma

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