Immunohistochemical analysis of P<sub>53</sub>and bcl-2 in benign and malignant salivary glands tumors

Al‐Rawi, Natheer H; Omer, Husam Eldein; Kawas, Sausan Al

doi:10.1111/j.1600-0714.2009.00816.x

Cited by 15 publications

(12 citation statements)

References 37 publications

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“…This is in agreement with the results of Röijer et al (1997) and Al-Rawi et al (2010), who reported moderate p53 staining in their studied cases of ACC and correlated the associated immunoreactivity to the large size of the tumor, high grade, and extent of invasion. This is in agreement with the results of Röijer et al (1997) and Al-Rawi et al (2010), who reported moderate p53 staining in their studied cases of ACC and correlated the associated immunoreactivity to the large size of the tumor, high grade, and extent of invasion.…”

Section: Discussionsupporting

confidence: 93%

Expression of cell-cycle regulators p53, p27, and p21 in mucoepidermoid and adenoid cystic carcinomas of the minor salivary glands

Talaat¹

2013

Egyptian Journal of Pathology

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Expression of cell-cycle regulators p53, p27, and p21 in mucoepidermoid and adenoid cystic carcinomas of the minor salivary glands Iman M. TalaatBackground The orderly progression of cells through different phases of the cell cycle is orchestrated by various molecules and proteins. p53 plays a crucial role in stress response and tumor suppression. It is a unique cellular processor that integrates signals from various pathways in order to coordinate cell proliferation, differentiation, and apoptosis. p21 WAF1/CIP1 and p27 have key positions in cellcycle regulations, leading to arrest of cell proliferation. They enable a repair process of DNA damage. In several human tumors, a loss of these proteins is associated with poor clinical outcome. Despite recent progress in molecular medicine, there is still a paucity of data on the involvement of cell-cycle regulatory proteins in the pathogenesis of salivary gland tumors.Aim The present work was performed to assess the immunohistochemical expression of p53, p27, and p21 in 15 patients with mucoepidermoid carcinomas (MECs) and adenoid cystic carcinomas (ACCs) of the minor salivary glands and their possible correlation with histopathologic grading.Results The present study included eight patients with ACC and seven patients with MEC. Most of the ACC patients (62.5%) showed positive reaction for p53, whereas only 25% were immunoreactive to p21. Among the seven examined MEC patients, the overall expression of p53 was detected only in those with high-grade tumors. With respect to p21, a moderate reaction was detected in a patient with low-grade MEC. In contrast, immunoreactivity to the p27 protein was detected only in low-grade tumors.Conclusion The cell-cycle regulatory protein p53 was highly expressed in high-grade neoplasms, whereas the reverse was noticed in the case of p27. These findings have a strong prognostic impact. p21 overexpression may be a useful prognostic marker when evaluated in conjunction with p53 status.

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Section: Discussionsupporting

confidence: 93%

Expression of cell-cycle regulators p53, p27, and p21 in mucoepidermoid and adenoid cystic carcinomas of the minor salivary glands

Talaat¹

2013

Egyptian Journal of Pathology

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“…13 Several biomarkers have been studied for their possible role as prognostic indicators of ACC in the lacrimal and salivary glands and as potential targets of molecular therapy. [14][15][16][17][18][19][20][21][22][23][24] No validated protocols exist for ACC of the lacrimal glands.…”

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker

et al. 2013

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“…Positive p53 immunohistochemistry has been identified not only in malignant salivary gland tumors but also in tumors showing classic pleomorphic adenoma histology, cellular pleomorphic adenomas, and recurrent pleomorphic adenomas. [21][22][23] More significant is the utility of the nuclear antigen K i -67 as a predictor of tumor behavior, in malignant tumors a high proliferation rate is suggestive of more aggressive behavior. 24 The low proliferation rate in addition to classic pleomorphic adenoma histology with no evidence of malignant transformation of either cellular or stromal components definitively placed this tumor into the category of a recurrent pleomorphic adenoma.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2012

J Neurol Surg Rep

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A 53-year-old man presented to the emergency department with a 7-day history of right ear fullness, otalgia, and hearing loss. He had recently been treated with antibiotics for sinusitis at an outside hospital but his symptoms failed to resolve. He denied vertigo, dizziness, otorrhea, or tinnitus. Physical examination demonstrated a mass behind an intact right eardrum, and tuning fork evidence of a conductive hearing loss. The remainder of his cranial nerve examination was normal, with the exception of the long-standing HouseBrackmann Grade VI/VI right facial nerve paralysis. Audiogram demonstrated a right moderate conductive hearing loss with flat (Type B) tympanogram. The left side was normal.The patient had a right parotid pleomorphic adenoma 35 years ago, which was treated by enucleation. He presented with several subcutaneous nodules 7 years after the initial treatment, which were treated by total parotidectomy. During surgery the facial nerve was sacrificed due to tumor encasement. Pathology confirmed recurrent pleomorphic adenoma. Postoperatively the tumor bed was treated with external beam radiotherapy. After this he remained asymptomatic for nearly 30 years.Magnetic resonance imaging of the head confirmed a large, irregular, heterogeneous, and variably enhancing mass in the right mastoid with extension medially along the floor of the posterior fossa measuring $5 Â 5 Â 5 cm (►Fig. 1). The mass eroded through the mastoid laterally and inferiorly into the upper cervical soft tissues. The superior portions of the mastoid were opacified with enhancement, suggesting tumor infiltration. The mass extended inferiorly into the parapharyngeal space and extrinsically compressed the right sigmoid sinus displacing it medially. In addition, a 1 Â 1 cm enhancing nodule in the right cerebellum medial to the cystic lesion was observed. The differential diagnosis at this point included carcinoma ex AbstractPleomorphic adenoma, also known as benign mixed tumor, is the most common tumor affecting the parotid gland and can reach massive size; however, intracranial invasion is rare. Recurrence of pleomorphic adenoma after excision is a well-known phenomenon and can present decades after resection of the primary tumor. Here we present the case of a 53-year-old man who presented to our clinic with ear fullness, otalgia, and hearing loss 30 years after undergoing total parotidectomy and external beam radiotherapy for pleomorphic adenoma. Magnetic resonance imaging revealed a massive transcranial tumor invading the mastoid cavity, the dura of the posterior fossa, the fallopian and semicircular canals, the jugular foramen, the lateral infratemporal fossa skull base, the sigmoid and transverse sinuses, and the superior parapharyngeal region. Gross examination and histopathological studies confirmed that the mass was a recurrent pleomorphic adenoma. Here we discuss the features of recurrent pleomorphic adenoma and review the current literature.

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Immunohistochemical analysis of P₅₃and bcl-2 in benign and malignant salivary glands tumors

Cited by 15 publications

References 37 publications

Expression of cell-cycle regulators p53, p27, and p21 in mucoepidermoid and adenoid cystic carcinomas of the minor salivary glands

Expression of cell-cycle regulators p53, p27, and p21 in mucoepidermoid and adenoid cystic carcinomas of the minor salivary glands

Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker

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Immunohistochemical analysis of P53and bcl-2 in benign and malignant salivary glands tumors

Cited by 15 publications

References 37 publications

Expression of cell-cycle regulators p53, p27, and p21 in mucoepidermoid and adenoid cystic carcinomas of the minor salivary glands

Expression of cell-cycle regulators p53, p27, and p21 in mucoepidermoid and adenoid cystic carcinomas of the minor salivary glands

Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker

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Immunohistochemical analysis of P₅₃and bcl-2 in benign and malignant salivary glands tumors