Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma

Mega, Seiji; Miyamoto, Masaki; Li, Li; Kadoya, Masumi; Takahashi, Ryo; Hase, Ryunosuke; Kaneko, Hiroyuki; Shichinohe, Toshiaki; Kawarada, Yo; Itoh, Tomoo; Morikawa, Toshiaki; Kondo, Satoshi

doi:10.1111/j.1442-2050.2006.00604.x

Cited by 19 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although a prognostic value of survivin expression in esophageal cancer has been reported by several studies (29)(30)(31)(32)(33)36,38), there exist some conf licting data (29,42,43). In this context, our analysis revealed no significant correlation between survivin expression and overall survival in ESCC or EAC patients.…”

Section: Adenocarcinomacontrasting

confidence: 46%

“…In ESCC survivin expression could be correlated with clinicopathological parameters and was linked to poor survival in the majority of published studies (29)(30)(31)(32)(33)(34)(35)(36). In contrast, the prognostic impact of XIAP expression and its association to pathological variables in ESCC patients has not yet been adequately investigated.…”

Section: Adenocarcinomamentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer

et al. 2018

View full text Add to dashboard Cite

Abstract. Based on their overexpression and important roles in progression and therapy-resistance in malignant diseases, the inhibitor of apoptosis protein family (IAP) members, survivin and X-linked inhibitor of apoptosis protein (XIAP), represent attractive candidates for targeted therapy. The present study investigated the prognostic and biological relevance of survivin and XIAP in esophageal squamous-cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Survivin and XIAP expression was analyzed by immunohistochemistry using tissue microarrays containing 120 ESCC and 90 EAC samples as well as the corresponding non-neoplastic esophageal mucosa samples. IAP expression levels were then correlated to clinicopathological parameters and overall survival to identify any associations. In addition, esophageal cancer cell lines were treated with the survivin inhibitor YM155, and the XIAP inhibitors Birinapant and GDC-0152 in vitro. Survivin and XIAP expression were significantly increased in EAC and ESCC when compared with tumor-adjacent mucosa. In patients with ESCC XIAP expression was associated with female gender and advanced tumor stages, and nuclear survivin expression was associated with poor grading. High XIAP expression was identified as an independent negative prognostic marker in ESCC. By contrast, XIAP inhibitors did not affect cancer cell viability in vitro, and the small molecule survivin inhibitor YM155 significantly reduced cell viability and proliferation in esophageal cancer cell lines. Western blot analysis revealed a dose dependent decrease of survivin accompanied by an increased poly (adenosine diphosphate-ribose) polymerase cleavage following YM155 treatment. These findings underline the potential role of survivin and XIAP in the oncogenesis of esophageal cancer and provide a rationale for future clinical studies investigating the therapeutic efficacy of IAP directed therapies in patients with esophageal cancer.

show abstract

Section: Adenocarcinomacontrasting

confidence: 46%

Section: Adenocarcinomamentioning

confidence: 99%

Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Concerning the studies using immunohistochemical examinations, three of the four studies reported nuclear survivin expression as a prognostic predictor in ESCC [9,12,13]. However, Dabrowski stated that survivin expression could not Fig.…”

Section: Discussionmentioning

confidence: 92%

“…Several studies have been published concerning the implication of the correlation between survivin expression and clinicopathological parameters in ESCC [7][8][9][10]12,13,16]. Of these, four studies examined mRNA expression using RT-PCR and others examined protein expression by immunohistochemical staining.…”

Section: Discussionmentioning

confidence: 99%

“…However, only a few studies concerning survivin in oesophageal squamous cell carcinoma (ESCC) have included a small series, although ESCC remains a major histological feature and generally reveals unfavourable prognosis despite the availability of multimodal therapies in Asia, including Japan [7][8][9][10][11][12][13][14]. In addition, no studies have examined splice variant expression of survivin in ESCC.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Survivin expression in oesophageal squamous cell carcinoma: its prognostic impact and splice variant expression

Takeno

Yamashita

Takahashi

et al. 2009

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

show abstract

Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma

et al. 2012

View full text Add to dashboard Cite

Survivin, a member of the inhibitor of apoptosis protein gene family, inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localization of survivin could predict survival of patients with upper urinary tract urothelial carcinoma (UUTUC). Immunohistochemical staining for survivin was carried out on archival specimens from 125 consecutive patients with UUTUC who underwent radical nephroureterectomy. Nuclear and cytoplasmic staining of survivin was scored and compared with clinicopathologic features and cancer-specific survival (CSS). Nuclear expression of survivin was significantly correlated with tumor grade (p < 0.001), lymphovascular invasion (p = 0.022) and poor survival with an estimated 5-year CSS probability of 54 % for tumors with nuclear expression of survivin vs. 73 % for those without nuclear expression of survivin (hazard ratio = 2.19; 95 % confidence interval = 1.02-4.70; p = 0.043). The 5-year cancer-specific survival rates of patients with cytoplasmic survivin-negative and -positive tumors were 66 and 67 %, respectively. There was no difference in survival between patients with cytoplasmic survivin-negative tumors and those with cytoplasmic survivin-positive tumors. Using univariate analysis, nuclear survivin expression, tumor grade, pathological T stage, pathological N stage, and lymphovascular invasion were the predictive variables for CSS. In contrast, cytoplasmic survivin expression had no prognostic relevance. These data suggest that nuclear accumulation of survivin represents biologic aggressiveness and that nuclear survivin is a negative prognostic marker in patients with resected UUTUC.

show abstract

Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma

Cited by 19 publications

References 21 publications

Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer

Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer

Survivin expression in oesophageal squamous cell carcinoma: its prognostic impact and splice variant expression

Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma

Contact Info

Product

Resources

About