Immunohistochemical Analysis of Nestin, Osteopontin, and Proliferating Cells in the Reparative Process of Exposed Dental Pulp Capped with Mineral Trioxide Aggregate

Kuratate, Momoko; Yoshiba, Kunihiko; Shigetani, Yoshimi; Yoshiba, Nagako; Ohshima, Hayato; Okiji, Takashi

doi:10.1016/j.joen.2008.03.021

Cited by 135 publications

(148 citation statements)

References 34 publications

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“…그 결과 치수 조직은 치유 과정을 통해 생활력을 회복하게 되며, 특히 손상받은 odontoblast가 회복되면 그 결과 조직의 mineralization이 나타나게 된다. [2][3][4][5][6][7][8][9] 이는, odontoblast의 주된 역할이 전상아질 및 상아질의 기질 (collagen, proteoglycans)을 생산하고, 칼슘 이온을 운반 하여 전상아질 및 상아질의 석회화를 일으키는 것이기 때문 에 나타나는 현상이다. 10) 외부 자극에 대한 반응으로 나타나는 치아의 mineralization은 주로 삼차 상아질(tertiary dentin) 형성으로 이루 어진다.…”

Section: ⅰ 서 론unclassified

Histology of dental pulp healing after tooth replantation in rats

Go¹,

Jung²,

Kim³

et al. 2010

J Korean Acad Conserv Dent

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The objective of this study was to observe the histology of dental pulp healing after tooth replantation in rats. The maxillary right first molars of 4-week-old rat were extracted, and then the teeth were repositioned in the original socket. At 3 days after replantation, there was localized inflammatory reaction. But, pulp revasculization and healing had already begun in the root area. At 5 days after replantation, odontoblast-like cells were observed. Tertiary dentin deposition was observed beneath the pulp-dentin border from 1 week after replantation. And tertiary dentin was increased at 2 weeks after replantation. The presence of odontoblast-like cells and the formation of tertiary dentin were continued to 4 weeks after replantation. At 4 weeks after replantation, the deposition of bone-like tissues and cementum-like tissues was observed. This results show that there is a possibility of pulp healing after tooth replantation in rats and the mineralization of tooth can progress. The mineralization of tooth after replantation was initially occurred by the deposition of tertiary dentin, but as time passed, the deposition of bone-like tissues and cementum-like tissues was begun and increased. [J Kor Acad Cons Dent 35(4):273-284, 2010]

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Section: ⅰ 서 론unclassified

Histology of dental pulp healing after tooth replantation in rats

Go¹,

Jung²,

Kim³

et al. 2010

J Korean Acad Conserv Dent

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“…In animal experiments, MTA capping was confirmed to cause mild necrotic changes followed by progressive new matrix formation and calcified bridging. Pulpal responses to MTA capping involve proliferation and migration of progenitors followed by differentiation into odontoblast-like cells, a mechanism basically similar to that found with Ca(OH) 2 , where osteopontin is thought to play a triggering role in initiation of the pulpal reparative process (Kuratate et al, 2008). Long-term success using MTA for direct pulp capping has been reported recently in clinical studies over an observation period of 9 years (Bogen et al, 2008).…”

Section: Vital Pulp Therapymentioning

confidence: 68%

“…The use of various cementbased compounds, such as calcium hydroxide [Ca(OH) 2 ] and mineral trioxide aggregate (MTA), is believed to promote the activity of dentinogenesis (Huang, 2009a). MTA is a newly developed pulp-capping material that resists bacterial leakage and may provide protection for the pulp, which allows repair and continued pulp vitality in teeth when used in combination with a sealed restoration (Bogen et al, 2008;Kuratate et al, 2008). In animal experiments, MTA capping was confirmed to cause mild necrotic changes followed by progressive new matrix formation and calcified bridging.…”

Section: Vital Pulp Therapymentioning

confidence: 99%

Biological approaches toward dental pulp regeneration by tissue engineering

Sun

Jin

et al. 2010

J Tissue Eng Regen Med

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Root canal therapy has been the predominant approach in endodontic treatment, wherein the entire pulp is cleaned out and replaced with a gutta-percha filling. However, living pulp is critical for the maintenance of tooth homeostasis and essential for tooth longevity. An ideal form of therapy, therefore, might consist of regenerative approaches in which diseased/necrotic pulp tissues are removed and replaced with regenerated pulp tissues to revitalize the teeth. Dental pulp regeneration presents one of the most challenging issues in regenerative dentistry due to the poor intrinsic ability of pulp tissues for self-healing and regrowth. With the advent of modern tissue engineering and the discovery of dental stem cells, biological therapies have paved the way to utilize stem cells, delivered or internally recruited, to generate dental pulp tissues, where growth factors and a series of dentine extracellular matrix molecules are key mediators that regulate the complex cascade of regeneration events to be faithfully fulfilled.

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“…Oluşan matriksin mineralize olması ile başlangıçta osteodentin ve ardından tersiyer dentin formasyonu meydana gelir. [50][51][52][53] Ainechchi ve ark. 54 kalsiyum hidroksit ve MTA ile yapılan pulpatomi tedavilerini karşılaştırdıklarında, kalsiyum hidroksit ile oluşan sert dokunun bakteriyel sızıntıya izin verebilecek şekilde eksiklikler ve tünel defektleri içerdiğini, MTA ile oluşan dentin köprüsünde ise bu duruma rastlanmadığını bildirmişlerdir.…”

Section: Mi̇neral Tri̇oksi̇t Aggregate (Mta)unclassified

Vi̇tal Pulpa Tedavi̇leri̇nde Güncel Yaklaşimlar

Gökçek¹,

Bodrumlu²

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZDiş çürükleri pulpal inflamasyona yol açabilen ve ileri dönemlerde diş kaybıyla sonuçlanabilen yaygın bir sağlık problemidir. İnflamasyon nedeniyle pulpa dokusu geri dönüşümlü olarak etkilendiğinde; indirekt pulpa kaplaması, direkt pulpa kaplaması, parsiyel/total pulpatomi gibi vital pulpa tedavi yöntemleri uygulanarak pulpanın canlılığının ve fonksiyonunun devam ettirilmesi sağlanabilmektedir. Dişlerin gelişim süreci boyunca meydana gelen moleküler ve histolojik değişimlerin anlaşılması ile birlikte, son yıllarda gözlenen yenilikler vital pulpa tedavilerinde yeni yaklaşımları gündeme getirmiştir Bu derlemenin amacı; dişlerin vitalitesini korumak için geçmişten günümüze kadar uygulanan vital pulpa tedavi yöntemlerinin ve kullanılan kaplama ajanlarının pulpa dokusu üzerindeki etkilerini değerlendirmektir. Anahtar Kelimeler: Vital pulpa tedavileri, kalsiyum hidroksit, MTA, Biodentin. GİRİŞPulpa, dişin kron ve kök kısmında bulunan, dentin ile çevrelenen, şekil verici, besleyici, duyusal ve koruyucu işlevlere sahip, ektomezenşim kökenli damarlanmış ve sinir ağıyla sarılmış bir bağ dokusudur. 1 Pulpa dokusunun inflamasyonu sonucunda oluşan vazodilatasyon ve artan damar permeabilitesi, pulpal doku basıncının artmasına yol açarak dokunun lokal feed-back mekanizmasını harekete geçirmek-tedir.2 Feed-back mekanizmasına göre inflame pulpada artan interstisyel basınç transkapiller hidrostatik basınç farkını düşürür ve filtrasyona engel olur. Ayrıca lokal ABSTRACTDental caries is a common problem that can cause pulpal inflammation and resultant tooth loss. When pulp tissue is reversibly inflammed, vital pulp therapies like indirect pulp capping, direct pulp capping, partial/total pulpatomy procedures are implemented to preserve vitality and function of the pulp tissue. Recent progress in understanding the molecular and histologic changes during the tooth development is lead to designing new treatment strategies in vital pulp therapies. The aim of this review is to provide an overview of vital pulp therapy from past to present and to assess the efficiency of the pulp capping materials on the pulp tissue. Key Words: Vital pulp therapy, calcium hydroxide, MTA, Biodentine olarak artmış olan interstisyel basınç inflamasyonun görülmediği bitişik dokudaki kapillerin interstisyel sıvıyı absorbe etmesine yardımcı olur ve lenf akışını arttırır. 3Bu iki mekanizma ile doku basıncının artmasına yol açan sıvı, etkilenmiş alanının dışına çıkarılarak doku basıncı düşürülmüş olur.2 Pulpanın inflamasyon sonrası uzun süre kendini koruyabilmesi ve uygun şartlar sağlandığında inflamasyonun gerileyerek pulpal sağlığın tekrar elde edilebilmesi bu mekanizmalar ile açıklanabilmektedir. Pulpa dokusunda tamirin meydana gelebilmesi için vital pulpanın varlığı şarttır

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Immunohistochemical Analysis of Nestin, Osteopontin, and Proliferating Cells in the Reparative Process of Exposed Dental Pulp Capped with Mineral Trioxide Aggregate

Cited by 135 publications

References 34 publications

Histology of dental pulp healing after tooth replantation in rats

Histology of dental pulp healing after tooth replantation in rats

Biological approaches toward dental pulp regeneration by tissue engineering

Vi̇tal Pulpa Tedavi̇leri̇nde Güncel Yaklaşimlar

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